Adjuvant Chemoradiation Plus Intraoperative Radiotherapy Versus Adjuvant Chemoradiation Alone in Patients With Locally Advanced Rectal Cancer

2015 ◽  
Vol 38 (1) ◽  
pp. 11-16 ◽  
Author(s):  
Qing Zhang ◽  
Jeremy Tey ◽  
Zhe Yang ◽  
Ping Li ◽  
Lihua Peng ◽  
...  
Keyword(s):  
Rectal Cancer ◽  
Locally Advanced ◽  
Intraoperative Radiotherapy ◽  
Advanced Rectal Cancer ◽  
Locally Advanced Rectal Cancer ◽  
Adjuvant Chemoradiation

scholarly journals Deep Learning and Radiomics predict complete response after neo-adjuvant chemoradiation for locally advanced rectal cancer

2018 ◽  
Vol 8 (1) ◽  
Author(s):  
Jean-Emmanuel Bibault ◽  
Philippe Giraud ◽  
Martin Housset ◽  
Catherine Durdux ◽  
Julien Taieb ◽  
...  
Keyword(s):  
Rectal Cancer ◽  
Deep Learning ◽  
Locally Advanced ◽  
Complete Response ◽  
Advanced Rectal Cancer ◽  
Locally Advanced Rectal Cancer ◽  
Adjuvant Chemoradiation

22 ORAL How good is MRI after neo-adjuvant chemoradiation of locally advanced rectal cancer?

2006 ◽  
Vol 32 ◽  
pp. S8
Author(s):  
G. Beets ◽  
R. Vliegen ◽  
G. Lammering ◽  
E. Dresen ◽  
H. Rutten ◽  
...  
Keyword(s):  
Rectal Cancer ◽  
Locally Advanced ◽  
Advanced Rectal Cancer ◽  
Locally Advanced Rectal Cancer ◽  
Adjuvant Chemoradiation

scholarly journals Intraoperative radiotherapy as an immediate adjuvant treatment of rectal cancer due to limited access to external-beam radiotherapy

2020 ◽  
Vol 15 (1) ◽  
Author(s):  
Sergey Potemin ◽  
Jens Kübler ◽  
Ivan Uvarov ◽  
Frederik Wenz ◽  
Frank Giordano
Keyword(s):  
Rectal Cancer ◽  
External Beam Radiotherapy ◽  
Locally Advanced ◽  
Intraoperative Radiotherapy ◽  
Advanced Rectal Cancer ◽  
Locally Advanced Rectal Cancer ◽  
External Beam ◽  
Median Dose ◽  
Limited Access ◽  
Local Progression

Abstract Background Neoadjuvant external-beam radiotherapy (EBRT) with concomitant chemotherapy is the current standard-of-care for locally-advanced rectal cancer. Intraoperative radiotherapy (IORT) is to date only recommended for pelvic recurrences or incompletely resectable tumors. We here report on patients with stage II/III rectal cancer that were treated with IORT in a regional Russian university center due to limited access to EBRT. Methods We retrospectively analyzed data from patients that were diagnosed with locally-advanced rectal cancer and underwent surgery from December 2012 to October 2016 at a regional oncological center in Russia (Krasnodar). During this period, access to EBRT was limited due to a temporary lack of a sufficient number of EBRT facilities. Patients unable to travel to a distant radiotherapy site received IORT alone, those that could travel received neoadjuvant external beam (chemo-) radiotherapy. Factors of interest were tumor stage, tumor differentiation, resection status, surgery type and neoadjuvant or adjuvant chemotherapy. We assessed local progression-free survival (L-PFS), PFS and overall survival (OS). Results A total of 172 patients were included in this analysis. Of those, 92 (53.5%) were treated with IORT alone (median dose: 15 Gy [8.4–17 Gy]) and 80 (46.5%) received both neoadjuvant EBRT (median dose: 50.4 Gy [40–50.4 Gy]) and IORT (median dose: 15 Gy [15–17 Gy]). The median age was 65 years [33–82]. The median follow-up was 23 months [0–63 months]. The incidence of toxicity was low in both groups with an overall complication rate of 5.4%. Local PFS at 4 years was comparable with 59.4% in the IORT group and 65.4% in the IORT/EBRT group (p = 0.70). Similarly, there was no difference in OS or PFS (p = 0.66, p = 0.51, respectively). Conclusions IORT is a valuable option for patients with locally-advanced rectal cancer in the absence of access to EBRT.

Value of Intraoperative Radiotherapy in Locally Advanced Rectal Cancer

2006 ◽  
Vol 49 (9) ◽  
pp. 1257-1265 ◽  
Author(s):  
Floris T. J. Ferenschild ◽  
Maarten Vermaas ◽  
Joost J. M. E. Nuyttens ◽  
Wilfried J. Graveland ◽  
Andreas W. K. S. Marinelli ◽  
...  
Keyword(s):  
Rectal Cancer ◽  
Locally Advanced ◽  
Intraoperative Radiotherapy ◽  
Advanced Rectal Cancer ◽  
Locally Advanced Rectal Cancer
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