The So-Called Aggressive Digital Papillary Adenocarcinoma Is Epithelial–Myoepithelial Carcinoma

Introduction Epithelial myoepithelial carcinoma (EMC) of the nasal cavity is a rare tumor, and here we describe the first case of EMC of the nasal cavity presenting with epiphora. A case presentation and review of the literature is provided. Methods A case report is described of a 63-year-old man who presented with unilateral epiphora and was found via a thorough history and physical examination to have a nasal tumor. The physical examination consisted of an ocular examination, including probing and irrigation, and a detailed nasal examination (anterior rhinoscopy, nasal endoscopy). The nasal examination was prompted by the patient's report of concurrent nasal symptoms during history taking. Immunohistochemistry subsequently identified the nasal tumor as EMC. A literature search was performed to gain insights into similar malignancies of the nasal cavity. Results Eight cases of EMC of the nasal cavity were identified in the literature, none of the patients presented with epiphora. The case presented here resulted in resolution of the patient's symptoms and no evidence of disease after surgical excision. Conclusion Epithelial myoepithelial is a rare salivary gland malignancy that can arise in the nasal cavity. Unilateral epiphora with concurrent nasal symptoms should prompt nasal cavity examination for the possibility of an obstructive tumor.

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Aggressive digital papillary adenocarcinoma: A report of two diseases and review of the literature

Journal of the American Academy of Dermatology ◽

10.1016/j.jaad.2008.07.038 ◽

2009 ◽

Vol 60 (2) ◽

pp. 331-339 ◽

Cited By ~ 39

Author(s):

Jamie Frey ◽

Cristina Shimek ◽

Courtney Woodmansee ◽

Erinn Myers ◽

Sarah Greer ◽

...

Keyword(s):

Papillary Adenocarcinoma ◽

Review Of The Literature ◽

Aggressive Digital Papillary Adenocarcinoma

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Ki-67 Index in Salivary Gland Neoplasms

International Journal of Phonosurgery & Laryngology ◽

10.5005/jp-journals-10023-1110 ◽

2016 ◽

Vol 6 (1) ◽

pp. 1-7

Author(s):

Suma Kaza ◽

T Jaya Mastan Rao ◽

Anupama Mikkilineni ◽

G Venkata Ratnam ◽

D Ranga Rao

Keyword(s):

Salivary Gland ◽

Pleomorphic Adenoma ◽

Mucoepidermoid Carcinoma ◽

Salivary Gland Neoplasms ◽

Carcinoma Ex Pleomorphic Adenoma ◽

Myoepithelial Carcinoma ◽

Cell Adenoma ◽

Ki 67 ◽

Adenoid Cystic ◽

Epithelial Myoepithelial Carcinoma

Abstract Assessment of proliferation is a means of predicting local recurrence and metastatic potential of malignancies. A mitotic count is not an ideal marker for proliferation in certain situations, such as salivary gland neoplasms. Ki-67 expression as a proliferation marker has been investigated in many human tumors. In the present study, Mitotic index (MI) and Ki-67 index were studied in pleomorphic adenoma, basal cell adenoma, mucoepidermoid carcinoma, adenoid cystic carcinoma epithelial myoepithelial carcinoma, carcinoma ex Pleomorphic adenoma and adenocarcinoma of salivary glands. The results were compared. The MI was similar in benign neoplasms, mucoepidermoid carcinoma and epithelial myoepithelial carcinoma, whereas it was high in carcinoma ex pleomorphic adenoma, adenocarcinoma and adenoid cystic carcinoma. The Ki-67 index was different in basal cell adenoma and pleomorphic adenoma. It was helpful in differentiating high grade and low grade mucoepidermoid carcinoma. It highlighted the malignant behavior of epithelial myoepithelial carcinoma. It was concluded that Ki-67 in benign neoplasms is 5% or less and in malignant ones more than 23% with a few exceptions. In mucoepidermoid carcinoma and epithelial myoepithelial carcinoma, Ki-67 index was found to be a better indicator for aggressiveness. These findings will be presented in this paper, with review of literature. How to cite this article Kaza S, Rao TJM, Mikkilineni A, Ratnam GV, Rao DR. Ki-67 Index in Salivary Gland Neoplasms. Int J Phonosurg Laryngol 2016;6(1):1-7.

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