Safety of Allogeneic Adipose Tissue-Derived Mesenchymal Stem Cells for the Treatment of Complex Perianal Fistulas Not Associated With Crohn’s Disease

2021 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Víctor Manuel Maciel Gutiérrez ◽  
Sergio Giovanni Gutiérrez Guillen ◽  
Manuel Willebaldo Centeno Flores ◽  
Jesús Alonso Valenzuela Pérez ◽  
Francisco Manuel Abarca Rendón ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Adipose Tissue ◽  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Perianal Fistulas

scholarly journals Autologous Mesenchymal Stem Cells, Applied in a Bioabsorbable Matrix, for Treatment of Perianal Fistulas in Patients With Crohn's Disease

2017 ◽  
Vol 153 (1) ◽  
pp. 59-62.e2 ◽  
Author(s):  
Allan B. Dietz ◽  
Eric J. Dozois ◽  
Joel G. Fletcher ◽  
Greg W. Butler ◽  
Darcie Radel ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Perianal Fistulas ◽  
Autologous Mesenchymal Stem Cells

Mesenchymal stem cells for the treatment of complex perianal fistulas in patients with Crohn disease

2019 ◽  
Vol 91 (3) ◽  
pp. 1-5
Author(s):  
Katarzyna Borycka-Kiciak ◽  
Anna Pietrzak ◽  
Maciej Kielar ◽  
Wiesław Tarnowski
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Current Knowledge ◽  
Mechanisms Of Action ◽  
Local Administration ◽  
Complex Mechanism ◽  
Perianal Fistulas ◽  
Favorable Safety

Abstract Treatment of perianal fistulizing Crohn’s disease is demanding and burdened with a high percentage of failures, which forces clinicians to search for new, more effective therapeutic options. One of these options is the use of adipose-derived mesenchymal stem cells in local administration. Due to their multipotentiality and complex mechanism of action, stem cells are the promising new therapeutic approach for the treatment-refractory complex perianal fistulas - demonstrating both high efficacy and a favorable safety profile. The paper presents current knowledge on the mechanisms of action and manner of administration of mesenchymal stem cells, as well as the effectiveness and safety of their use in the treatment of perianal Crohn's disease based on available literature.

Expanded allogeneic adipose-derived mesenchymal stem cells (Cx601) for complex perianal fistulas in Crohn's disease: a phase 3 randomised, double-blind controlled trial

The Lancet ◽  
2016 ◽  
Vol 388 (10051) ◽  
pp. 1281-1290 ◽  
Author(s):  
Julián Panés ◽  
Damián García-Olmo ◽  
Gert Van Assche ◽  
Jean Frederic Colombel ◽  
Walter Reinisch ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Controlled Trial ◽  
Phase 3 ◽  
Double Blind ◽  
Perianal Fistulas
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