Gestational weight gain and long-term maternal obesity risk

Abstract Background Early adiposity rebound (AR) has been associated with increased risk of overweight or obesity in adulthood. However, little is known about early predictors of age at AR. We aimed to study the role of perinatal factors and genetic susceptibility to obesity in the kinetics of AR. Methods Body mass index (BMI) curves were modelled by using mixed-effects cubic models, and age at AR was estimated for 1415 children of the EDEN mother–child cohort study. A combined obesity risk-allele score was calculated from genotypes for 27 variants identified by genome-wide association studies of adult BMI. Perinatal factors of interest were maternal age at delivery, parental education, parental BMI, gestational weight gain, maternal smoking during pregnancy, and newborn characteristics (sex, prematurity, and birth weight). We used a hierarchical level approach with multivariable linear regression model to investigate the association between these factors, obesity risk-allele score, and age at AR. Results A higher genetic susceptibility to obesity score was associated with an earlier age at AR. At the most distal level of the hierarchical model, maternal and paternal educational levels were positively associated with age at AR. Children born to parents with higher BMI were more likely to exhibit earlier age at AR. In addition, higher gestational weight gain was related to earlier age at AR. For children born small for gestational age, the average age at AR was 88 [±39] days lower than for children born appropriate for gestational age and 91 [±56] days lower than for children born large for gestational age. Conclusion The timing of AR seems to be an early childhood manifestation of the genetic susceptibility to adult obesity. We further identified low birth weight and gestational weight gain as novel predictors of early AR, highlighting the role of the intrauterine environment in the kinetics of adiposity.

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Associations between cumulative neighborhood deprivation, long-term mobility trajectories, and gestational weight gain

Health & Place ◽

10.1016/j.healthplace.2018.05.007 ◽

2018 ◽

Vol 52 ◽

pp. 101-109 ◽

Cited By ~ 2

Author(s):

Irene Headen ◽

Mahasin Mujahid ◽

Julianna Deardorff ◽

David H. Rehkopf ◽

Barbara Abrams

Keyword(s):

Weight Gain ◽

Gestational Weight Gain ◽

Neighborhood Deprivation ◽

Gestational Weight

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Gestational weight gain and medical outcomes of pregnancy

Obstetric Medicine ◽

10.1177/1753495x15591320 ◽

2015 ◽

Vol 8 (3) ◽

pp. 133-137 ◽

Cited By ~ 28

Author(s):

Zachary M Ferraro ◽

Fernanda Contador ◽

Afaf Tawfiq ◽

Kristi B Adamo ◽

Laura Gaudet

Keyword(s):

Weight Gain ◽

Gestational Weight Gain ◽

Narrative Review ◽

Medical Complications ◽

Medical Outcomes ◽

Gestational Weight ◽

Pregnancy Weight

This narrative review discusses gestational weight gain (GWG) and medical outcomes of pregnancy, including metabolic, cardiovascular, respiratory, musculoskeletal and psychiatric systems. Taken as a whole, the available evidence shows that excessive GWG increases the risk of all medical complications of pregnancy, and negatively impacts the long-term health and weight of both mothers and their offspring. Briefly, interventions to encourage appropriate GWG are discussed and readers are directed to resources to facilitate discussion of pregnancy weight.

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Paternal and maternal obesity but not gestational weight gain is associated with type 1 diabetes

International Journal of Epidemiology ◽

10.1093/ije/dyx266 ◽

2018 ◽

Vol 47 (2) ◽

pp. 417-426 ◽

Cited By ~ 10

Author(s):

Maria C Magnus ◽

Sjurdur F Olsen ◽

Charlotta Granstrom ◽

Nicolai A Lund-Blix ◽

Jannet Svensson ◽

...

Keyword(s):

Type 1 Diabetes ◽

Weight Gain ◽

Gestational Weight Gain ◽

Maternal Obesity ◽

Gestational Weight

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Impact of maternal obesity on pregnancy course and maternal and perinatal complications

Medicinski podmladak ◽

10.5937/mp71-27850 ◽

2020 ◽

Vol 71 (3) ◽

pp. 54-58

Author(s):

Milan Lacković

Keyword(s):

Risk Factors ◽

Weight Gain ◽

Gestational Weight Gain ◽

Pregnancy Complications ◽

Maternal Obesity ◽

Overweight And Obesity ◽

Perinatal Complications ◽

Anthropometric Parameter ◽

Gestational Weight ◽

Excessive Gestational Weight Gain

The prevalence of obesity and obesity-related health problems is increasing worldwide, especially among woman and man of reproductive age and obesity is designated as one of the most important global health threats in 21st century. Pregnancy in obese woman is considered as a high-risk pregnancy. Pre-pregnancy obesity and excessive gestational weight gain (GWG) are distinct risk factors with differing associated adverse outcomes, but they could also carry a cumulative negative impact on pregnancy course. Pre-pregnancy obesity is the anthropometric parameter most strongly correlated with perinatal complications. Maternal complications following obesity include antepartum, intrapartum and postpartum complications, such as pregnancy related hypertension, preeclampsia, gestational diabetes mellitus, preterm birth, venous thromboembolism, labor dystocia, labor induction, instrumental and cesarean delivery. Fetal complications related to maternal obesity might include increased prevalence of congenital anomalies, growth abnormalities, prematurity and stillbirth. Pre- pregnancy overweight and obesity is a potentially modifiable risk factor compromising pregnancy outcome. Among all complications that might arise during pregnancy and that could not be predicted and therefore prevented, pre- pregnancy overweight and obesity management control can significantly reduce potential pregnancy complications. Pre-conceptual counseling should provide in a timely manner awareness of this arising medical condition and provide risk reduction of complications following pre- pregnancy obesity and excessive GWG obesity, pre-pregnancy obesity, excessive gestational weight gain, pregnancy risk factors, pregnancy complications

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