Adverse Cerebral Cardiovascular Events Associated with Checkpoint Kinase 1 Inhibitors

2021 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Tongtong Yang ◽  
Jie Gu ◽  
Chong Du ◽  
Tiankai Shan ◽  
Tianwen Wei ◽  
...  
Keyword(s):  
Cardiovascular Events ◽  
Checkpoint Kinase ◽  
Checkpoint Kinase 1

scholarly journals Pharmacophore Modeling and Virtual Screening Studies of Checkpoint Kinase 1 Inhibitors

2009 ◽  
Vol 57 (7) ◽  
pp. 704-709 ◽  
Author(s):  
Jin-Juan Chen ◽  
Ting-Lin Liu ◽  
Li-Jun Yang ◽  
Lin-Li Li ◽  
Yu-Quan Wei ◽  
...  
Keyword(s):  
Virtual Screening ◽  
Pharmacophore Modeling ◽  
Checkpoint Kinase ◽  
Checkpoint Kinase 1

scholarly journals Checkpoint kinase 1 inhibition sensitises transformed cells to dihydroorotate dehydrogenase inhibition

Oncotarget ◽  
2017 ◽  
Vol 8 (56) ◽  
pp. 95206-95222 ◽  
Author(s):  
Stéphanie Arnould ◽  
Geneviève Rodier ◽  
Gisèle Matar ◽  
Charles Vincent ◽  
Nelly Pirot ◽  
...  
Keyword(s):  
Transformed Cells ◽  
Dihydroorotate Dehydrogenase ◽  
Checkpoint Kinase ◽  
Checkpoint Kinase 1

scholarly journals Conformational Change of Human Checkpoint Kinase 1 (Chk1) Induced by DNA Damage

2016 ◽  
Vol 291 (25) ◽  
pp. 12951-12959 ◽  
Author(s):  
Xiangzi Han ◽  
Jinshan Tang ◽  
Jingna Wang ◽  
Feng Ren ◽  
Jinhua Zheng ◽  
...  
Keyword(s):  
Dna Damage ◽  
Conformational Change ◽  
Checkpoint Kinase ◽  
Checkpoint Kinase 1

Computer-Aided Drug Design of Pyranopyrazoles and Related Compounds for Checkpoint Kinase-1

2009 ◽  
Vol 6 (8) ◽  
pp. 579-584 ◽  
Author(s):  
Rahul Ramtekkar ◽  
Kandhasamy Kumarvel ◽  
Gnanasambandam Vasuki ◽  
K. Sekar ◽  
R. Krishna
Keyword(s):  
Drug Design ◽  
Computer Aided Drug Design ◽  
Checkpoint Kinase ◽  
Checkpoint Kinase 1 ◽  
Computer Aided ◽  
Related Compounds

A Casein kinase 1/Checkpoint kinase 1 pyrazolo-pyridine protein kinase inhibitor as novel activator of the p53 pathway

2013 ◽  
Vol 23 (20) ◽  
pp. 5578-5585 ◽  
Author(s):  
Anne-Sophie Huart ◽  
Barbara Saxty ◽  
Andy Merritt ◽  
Marta Nekulova ◽  
Stephen Lewis ◽  
...  
Keyword(s):  
Protein Kinase ◽  
Kinase Inhibitor ◽  
Casein Kinase ◽  
Protein Kinase Inhibitor ◽  
P53 Pathway ◽  
Casein Kinase 1 ◽  
Checkpoint Kinase ◽  
Checkpoint Kinase 1

A supported liquid extraction LC-MS/MS method for determination of concentrations of GDC-0425, a small molecule Checkpoint kinase 1 inhibitor, in human plasma

2016 ◽  
Vol 30 (12) ◽  
pp. 1984-1991 ◽  
Author(s):  
Xiao Ding ◽  
Yuan Chen ◽  
Srikumar Sahasranaman ◽  
Yifan Shi ◽  
Janine McKnight ◽  
...  
Keyword(s):  
Human Plasma ◽  
Small Molecule ◽  
Liquid Extraction ◽  
Checkpoint Kinase ◽  
Checkpoint Kinase 1
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