A supported liquid extraction LC-MS/MS method for determination of concentrations of GDC-0425, a small molecule Checkpoint kinase 1 inhibitor, in human plasma

2016 ◽  
Vol 30 (12) ◽  
pp. 1984-1991 ◽  
Author(s):  
Xiao Ding ◽  
Yuan Chen ◽  
Srikumar Sahasranaman ◽  
Yifan Shi ◽  
Janine McKnight ◽  
...  
Keyword(s):  
Human Plasma ◽  
Small Molecule ◽  
Liquid Extraction ◽  
Checkpoint Kinase ◽  
Checkpoint Kinase 1

An HPLC Determination of Trimetazidine in Human Plasma Using Liquid‐Liquid Extraction for Sample Clean‐Up

2005 ◽  
Vol 28 (9) ◽  
pp. 1299-1309 ◽  
Author(s):  
Min Kyo Jeoung ◽  
Kyoung Soon Kim ◽  
Chang Soo Kim ◽  
Nam Hee Kim ◽  
Youn‐Bok Chung ◽  
...  
Keyword(s):  
Human Plasma ◽  
Liquid Extraction ◽  
Hplc Determination ◽  
Liquid Liquid Extraction

scholarly journals RP-HPLC Method Development and Its Validation for Quantitative Determination of Rimonabant in Human Plasma

2012 ◽  
Vol 2012 ◽  
pp. 1-4 ◽  
Author(s):  
Shravan Bankey ◽  
Ganesh Tapadiya ◽  
Jasvant Lamale ◽  
Deepti Jain ◽  
Shweta Saboo ◽  
...  
Keyword(s):  
Human Plasma ◽  
Mobile Phase ◽  
Method Development ◽  
Bioequivalence Study ◽  
Hplc Method ◽  
Liquid Extraction ◽  
Liquid Liquid Extraction ◽  
Rp Hplc ◽  
Hplc Method Development

A simple, accurate, and precise HPLC method was developed and validated for determination of rimonabant in human plasma. Following liquid-liquid extraction, chromatographic separation was accomplished using C18 column with mobile phase consisting of acetonitrile : water (90 : 10, v/v), drug was detected at 260 nm using UVdetector. The LOD and LOQ were 3.0 and 10.0 μg/L, respectively. The method is linear in the interval 50.0–1000.0 μg/L. The average extraction recovery of drug from plasma was found to be 92.2%. The percent CV of the method was found to be less than 10.8%, and accuracy was found between 94.5 and 106.7%. The assay may be applied to a pharmacokinetic and bioequivalence study of rimonabant.

scholarly journals A LC–MS-MS assay for simultaneous determination of two glycopeptides and two small molecule compounds in human plasma

2018 ◽  
Vol 56 (9) ◽  
pp. 828-834
Author(s):  
Meiyun Shi ◽  
Xiaojun Zhao ◽  
Tingting Wang ◽  
Lei Yin ◽  
Yanyan Li
Keyword(s):  
Simultaneous Determination ◽  
Human Plasma ◽  
Small Molecule

Optimization of a liquid–liquid extraction method for HPLC–DAD determination of penicillin-V in human plasma

2002 ◽  
Vol 72 (1) ◽  
pp. 85-92 ◽  
Author(s):  
Andrei Medvedovici ◽  
Mihaela Ionescu ◽  
Constantin Mircioiu ◽  
Victor David
Keyword(s):  
Human Plasma ◽  
Extraction Method ◽  
Liquid Extraction ◽  
Penicillin V ◽  
Liquid Liquid Extraction
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