Validation of a Liquid Chromatography Method for the Simultaneous Determination of Several Nonsteroidal Anti-Inflammatory Drugs in Human Plasma for Therapeutic Drug Monitoring

2013 ◽  
pp. 1 ◽  
Author(s):  
Sally A. Helmy ◽  
Heba M. El-Bedaiwy
Keyword(s):  
Liquid Chromatography ◽  
Therapeutic Drug Monitoring ◽  
Simultaneous Determination ◽  
Human Plasma ◽  
Drug Monitoring ◽  
Therapeutic Drug ◽  
Chromatography Method ◽  
Inflammatory Drugs ◽  
Liquid Chromatography Method

A simple and automated online SPE-LC-MS/MS method for simultaneous determination of olanzapine, fluoxetine and norfluoxetine in human plasma and its application in therapeutic drug monitoring

RSC Advances ◽  
2015 ◽  
Vol 5 (43) ◽  
pp. 34342-34352 ◽  
Author(s):  
Yiran Fan ◽  
Guanghu Shen ◽  
Ping Li ◽  
Xiaonan Xi ◽  
Haiting Wu ◽  
...  
Keyword(s):  
Therapeutic Drug Monitoring ◽  
Simultaneous Determination ◽  
Human Plasma ◽  
Drug Monitoring ◽  
Sample Pretreatment ◽  
Therapeutic Drug ◽  
High Quality ◽  
Online Spe

An integration of sample pretreatment automation using online SPE technique could provide an easy to use, efficient, sensitive and high quality methods for TDM.

scholarly journals A validated liquid chromatography method for the simultaneous determination of vitamins A and E in human plasma

2007 ◽  
Vol 44 (4) ◽  
pp. 1001-1007 ◽  
Author(s):  
Danuta Siluk ◽  
Regina V. Oliveira ◽  
Maria Esther-Rodriguez-Rosas ◽  
Shari Ling ◽  
Angelo Bos ◽  
...  
Keyword(s):  
Liquid Chromatography ◽  
Simultaneous Determination ◽  
Human Plasma ◽  
Chromatography Method ◽  
Liquid Chromatography Method

scholarly journals Simultaneous Determination of 12 β-Lactam Antibiotics in Human Plasma by High-Performance Liquid Chromatography with UV Detection: Application to Therapeutic Drug Monitoring

2011 ◽  
Vol 55 (10) ◽  
pp. 4873-4879 ◽  
Author(s):  
Marie-Clémence Verdier ◽  
Olivier Tribut ◽  
Pierre Tattevin ◽  
Yves Le Tulzo ◽  
Christian Michelet ◽  
...  
Keyword(s):  
High Performance Liquid Chromatography ◽  
Liquid Chromatography ◽  
Therapeutic Drug Monitoring ◽  
Simultaneous Determination ◽  
Drug Monitoring ◽  
High Performance ◽  
Therapeutic Drug ◽  
Beta Lactam ◽  
Beta Lactam Antibiotics

ABSTRACTA rapid and specific high-performance liquid chromatography method with UV detection (HPLC-UV) for the simultaneous determination of 12 beta-lactam antibiotics (amoxicillin, cefepime, cefotaxime, ceftazidime, ceftriaxone, cloxacillin, imipenem, meropenem, oxacillin, penicillin G, piperacillin, and ticarcillin) in small samples of human plasma is described. Extraction consisted of protein precipitation by acetonitrile. An Atlantis T3 analytical column with a linear gradient of acetonitrile and a pH 2 phosphoric acid solution was used for separation. Wavelength photodiode array detection was set either at 210 nm, 230 nm, or 298 nm according to the compound. This method is accurate and reproducible (coefficient of variation [CV] < 8%), allowing quantification of beta-lactam plasma levels from 5 to 250 μg/ml without interference with other common drugs. This technique is easy to use in routine therapeutic drug monitoring of beta-lactam antibiotics.

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