MACULAR FUNCTION IN EYES WITH EARLY AGE-RELATED MACULAR DEGENERATION WITH OR WITHOUT CONTRALATERAL LATE AGE-RELATED MACULAR DEGENERATION

Retina ◽  
2007 ◽  
Vol 27 (7) ◽  
pp. 879-890 ◽  
Author(s):  
VINCENZO PARISI ◽  
LOREDANA PERILLO ◽  
MASSIMILIANO TEDESCHI ◽  
CECILIA SCASSA ◽  
GELTRUDE GALLINARO ◽  
...  
1997 ◽  
Vol 123 (6) ◽  
pp. 869-870
Author(s):  
C Degli ◽  
MC Blarzino ◽  
M Valenti ◽  
T Segato ◽  
E Mideno

2012 ◽  
Vol 2012 ◽  
pp. 1-9 ◽  
Author(s):  
M. Piccardi ◽  
D. Marangoni ◽  
A. M. Minnella ◽  
M. C. Savastano ◽  
P. Valentini ◽  
...  

Objectives. In a previous randomized clinical trial (Falsini et al. (2010)), it was shown that short-term Saffron supplementation improves retinal flicker sensitivity in early age-related macular degeneration (AMD). The aim of this study was to evaluate whether the observed functional benefits from Saffron supplementation may extend over a longer follow-up duration.Design. Longitudinal, interventional open-label study.Setting. Outpatient ophthalmology setting.Participants. Twenty-nine early AMD patients (age range: 55–85 years) with a baseline visual acuity >0.3.Intervention. Saffron oral supplementation (20 mg/day) over an average period of treatment of 14 (±2) months.Measurements. Clinical examination and focal-electroretinogram-(fERG-) derived macular (18°) flicker sensitivity estimate (Falsini et al. (2010)) every three months over a followup of 14 (±2) months. Retinal sensitivity, the reciprocal value of the estimated fERG amplitude threshold, was the main outcome measure.Results. After three months of supplementation, mean fERG sensitivity improved by 0.3 log units compared to baseline values (P<0.01), and mean visual acuity improved by two Snellen lines compared to baseline values (0.75 to 0.9,P<0.01). These changes remained stable over the follow-up period.Conclusion. These results indicate that in early AMD Saffron supplementation induces macular function improvements from baseline that are extended over a long-term followup.


2006 ◽  
Vol 83 (4) ◽  
pp. 880-886 ◽  
Author(s):  
Chung-Jung Chiu ◽  
Larry D Hubbard ◽  
Jane Armstrong ◽  
Gail Rogers ◽  
Paul F Jacques ◽  
...  

2004 ◽  
Vol 109 (1) ◽  
pp. 1-8 ◽  
Author(s):  
Changzheng Chen ◽  
Lezheng Wu ◽  
Dezheng Wu ◽  
Shizhou Huang ◽  
Feng Wen ◽  
...  

PLoS ONE ◽  
2020 ◽  
Vol 15 (10) ◽  
pp. e0240357
Author(s):  
Maho Sato ◽  
Sakiko Minami ◽  
Norihiro Nagai ◽  
Misa Suzuki ◽  
Toshihide Kurihara ◽  
...  

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