Fungal Keratitis and Contact Lenses: An Old Enemy Unrecognized or a New Nemesis on the Block?

2007 ◽  
Vol 33 (Supplement) ◽  
pp. 415-417 ◽  
Author(s):  
Sonal S. Tuli ◽  
Sandhya A. Iyer ◽  
William T. Driebe
Keyword(s):  
Contact Lenses ◽  
Fungal Keratitis

Bacterial and Fungal Keratitis: A Retrospective Analysis at a University Hospital in Switzerland

2019 ◽  
Vol 236 (04) ◽  
pp. 358-365 ◽  
Author(s):  
Alexandra Bograd ◽  
Theo Seiler ◽  
Sara Droz ◽  
Stefan Zimmerli ◽  
Beatrice Früh ◽  
...  
Keyword(s):  
Contact Lenses ◽  
Topical Therapy ◽  
Fungal Growth ◽  
Fungal Keratitis ◽  
University Hospital ◽  
Fusarium Spp ◽  
Candida Spp ◽  
Coagulase Negative Staphylococci ◽  
History Of ◽  
Time Periods

Abstract Background Infectious keratitis is a serious corneal disease and may lead to permanent visual deterioration if not treated rapidly and effectively. In order to determine possible changes in the spectrum of pathogens over time, we evaluated the pathogenic organisms of keratitis at a university hospital in Switzerland, comparing two time periods within a decade. Methods In this retrospective study, 417 patients with the clinical diagnosis of bacterial or fungal keratitis in 2006/07 and 2015/16 were enrolled. In an additional analysis, all cases of fungal keratitis between 2006 and 2016 were evaluated. Collected parameters were age, gender, side, use of contact lenses, systemic, neurological and ocular diseases, trauma, previous surgery, and systemic and topical therapy before presentation. In each patient, microbiological results of corneal smears such as growth and antibiotic resistance were analysed. Results A total of 163 and 254 eyes were included in 2006/07 and 2015/16, respectively. In 2006/07, a culture of smears revealed a bacterial cause in 70 eyes (42.9%) and a fungal cause in 4 eyes (2.5%), whereas in 2015/16, bacterial growth was found in 115 eyes (45.3%) and fungal growth in 6 eyes (2.4%). The most common bacteria in 2006/07 and 2015/16 were coagulase-negative Staphylococci (44.3 vs. 49.6%), Pseudomonas aeruginosa (18.6 vs. 13.9%), Staphylococcus aureus (10 vs. 16.5%), Corynebacterium spp. (8.6 vs. 5.2%), and Moraxella spp. (7.1 vs. 9.6%). Candida parapsilosis was the most common fungal isolate in both groups (25 vs. 33.3%). Between 2006 and 2016, fungal keratitis was found in 37 eyes (Candida spp. n = 11, Fusarium spp. n = 11, Aspergillus spp. n = 5, others n = 10). All patients with Fusarium spp. keratitis had a history of wearing contact lenses. Conclusion The most commonly isolated bacterial organisms were Staphylococci and Pseudomonas spp., whereas fungal keratitis was mainly due to Candida spp. or Fusarium spp. No relevant variation in causative pathogens was observed between the two time periods.

Fungal Keratitis Due to Beauveria bassiana in a Contact Lenses Wearer and Review of Published Reports

2016 ◽  
Vol 181 (9-10) ◽  
pp. 745-752 ◽  
Author(s):  
Ana Lara Oya ◽  
María Eloisa Medialdea Hurtado ◽  
María Dolores Rojo Martín ◽  
Antonia Aguilera Pérez ◽  
Ana Alastruey-Izquierdo ◽  
...  
Keyword(s):  
Beauveria Bassiana ◽  
Contact Lenses ◽  
Fungal Keratitis

scholarly journals REFRACTORY KERATITIS IN HOT CLIMATE

2006 ◽  
Vol 13 (01) ◽  
pp. 151-155
Author(s):  
ASAD JAMAL DAR ◽  
HASEEB AHMED ◽  
M.KASHIF HANIF ◽  
Ubaid Ullah Yasin
Keyword(s):  
Diabetes Mellitus ◽  
Standard Treatment ◽  
Contact Lenses ◽  
Poor Response ◽  
Fungal Keratitis ◽  
Treatment Regimes ◽  
Hot Climate ◽  
Fungal Hyphae ◽  
Culture And Sensitivity ◽  
Corneal Biopsy

This article presents patients with unilateral painful red eye refractory torecommended standard treatment regimes in which staining, culture and sensitivity reports were inconclusive. Onocular examination hazy cornea with central corneal abscess was common in all cases. Corneal biopsy was reservedfor cases with inconclusive laboratory reports as well as poor response to standard treatment regime. The formerrevealed fungal hyphae in all cases. Patients mentioned had general predisposition e.g. diabetes mellitus, hot climate(Multan) as well as predisposing factors such as contact lenses, dry eye syndrome, poor ocular hygiene, agriculturalbackground were more prone to fungal keratitis, hence better diagnosed and confirmed early by contemplating cornealbiopsy.

Fungal Keratitis Associated With Non-therapeutic Soft Contact Lenses

2006 ◽  
Vol 142 (1) ◽  
pp. 154-155 ◽  
Author(s):  
Eduardo C. Alfonso ◽  
Darlene Miller ◽  
Jorge Cantu-Dibildox ◽  
Terrence P. O’Brien ◽  
Oliver D. Schein
Keyword(s):  
Contact Lenses ◽  
Fungal Keratitis ◽  
Soft Contact ◽  
Soft Contact Lenses

scholarly journals Fusarium and Candida albicans Biofilms on Soft Contact Lenses: Model Development, Influence of Lens Type, and Susceptibility to Lens Care Solutions

2007 ◽  
Vol 52 (1) ◽  
pp. 171-182 ◽  
Author(s):  
Yoshifumi Imamura ◽  
Jyotsna Chandra ◽  
Pranab K. Mukherjee ◽  
Ali Abdul Lattif ◽  
Loretta B. Szczotka-Flynn ◽  
...  
Keyword(s):  
Candida Albicans ◽  
Contact Lens ◽  
Biofilm Formation ◽  
In Vitro Model ◽  
Contact Lenses ◽  
Fungal Keratitis ◽  
Soft Contact ◽  
Soft Contact Lenses ◽  
Vitro Model

ABSTRACT Fungal keratitis is commonly caused by Fusarium species and less commonly by Candida species. Recent outbreaks of Fusarium keratitis were associated with contact lens wear and with ReNu with MoistureLoc contact lens care solution, and biofilm formation on contact lens/lens cases was proposed to play a role in this outbreak. However, no in vitro model for contact lens-associated fungal biofilm has been developed. In this study, we developed and characterized in vitro models of biofilm formation on various soft contact lenses using three species of Fusarium and Candida albicans. The contact lenses tested were etafilcon A, galyfilcon A, lotrafilcon A, balafilcon A, alphafilcon A, and polymacon. Our results showed that clinical isolates of Fusarium and C. albicans formed biofilms on all types of lenses tested and that the biofilm architecture varied with the lens type. Moreover, differences in hyphal content and architecture were found between the biofilms formed by these fungi. We also found that two recently isolated keratitis-associated fusaria formed robust biofilms, while the reference ATCC 36031 strain (recommended by the International Organization for Standardization guidelines for testing of disinfectants) failed to form biofilm. Furthermore, using the developed in vitro biofilm model, we showed that phylogenetically diverse planktonic fusaria and Candida were susceptible to MoistureLoc and MultiPlus. However, Fusarium biofilms exhibited reduced susceptibility against these solutions in a species- and time-dependent manner. This in vitro model should provide a better understanding of the biology and pathogenesis of lens-related fungal keratitis.

Fungal Keratitis Associated With Contact Lenses

2007 ◽  
Vol 125 (4) ◽  
pp. 561 ◽  
Author(s):  
Elisabeth J. Cohen
Keyword(s):  
Contact Lenses ◽  
Fungal Keratitis

scholarly journals Case Report: Molecular Diagnosis of Fungal Keratitis Associated With Contact Lenses Caused by Fusarium solani

2021 ◽  
Vol 8 ◽  
Author(s):  
Laura Trovato ◽  
Antonio Marino ◽  
Giovanni Pizzo ◽  
Salvatore Oliveri
Keyword(s):  
Fusarium Solani ◽  
Fungal Pathogens ◽  
Contact Lenses ◽  
Rapid Change ◽  
Rapid Identification ◽  
Fungal Keratitis ◽  
Antifungal Treatment ◽  
Delay In Diagnosis ◽  
Soft Contact Lenses

Fusarium is a filamentous fungus commonly found in the environment and is the major cause of fungal keratitis. We report a case of keratomycosis caused by Fusarium solani in a patient using disposable soft contact lenses. A delay in diagnosis led to the initiation of an empirical antifungal treatment with the subsequent deterioration of the patient's clinical condition. The use of the real-time quantitative PCR assay confirmed keratitis from F. solani providing a result in <48 h and therefore giving the possibility of quickly starting targeted antifungal therapy. The patient had an improvement in eye condition after the diagnosis of keratitis by F. solani and the rapid change to targeted antifungal treatment. For the rapid identification of corneal fungal pathogens, we believe that PCR may be added for the diagnosis of mycotic keratitis pending the isolation in culture that is necessary for in vitro susceptibility testing.

Sign in / Sign up

Export Citation Format

Share Document