scholarly journals Assessment of Glaucomatous Damage After Boston Keratoprosthesis Implantation Based on Digital Planimetric Quantification of Visual Fields and Optic Nerve Head Imaging

Cornea ◽  
2018 ◽  
Vol 37 (5) ◽  
pp. 602-608 ◽  
Author(s):  
Mohsin H. Ali ◽  
Mark S. Dikopf ◽  
Anthony G. Finder ◽  
Ahmad A. Aref ◽  
Thasarat Vajaranant ◽  
...  
Keyword(s):  
Optic Nerve ◽  
Optic Nerve Head ◽  
Visual Fields ◽  
Glaucomatous Damage ◽  
Boston Keratoprosthesis

Influence of Nifedipine on the Visual Fields of Patients with Optic-Nerve-Head Diseases

1994 ◽  
Vol 4 (1) ◽  
pp. 24-28 ◽  
Author(s):  
A.Z. Gaspar ◽  
J. Flammer ◽  
PH. Hendrickson
Keyword(s):  
Optic Nerve ◽  
Visual Field ◽  
Calcium Channel ◽  
Calcium Channel Blocker ◽  
Optic Nerve Head ◽  
Channel Blocker ◽  
Glaucoma Patient ◽  
Visual Fields ◽  
Visual Field Defects ◽  
Channel Blockers

Calcium-channel blockers have long been employed in coronary disease, and recent investigations have indicated their efficacy in improving the visual field in low-tension glaucoma or presumed vasospasm, possibly by enhancing ocular circulation. We evaluated the short-term influence of a typical calcium-channel blocker, nifedipine, on 59 patients with visual-field defects, some with optic-nerve-head pathology (n = 38) and some with normal-appearing optic nerve heads (n = 21). On the average, a statistically significant improvement of 1.2 dB was observed. Different types of patients, however, behaved quite differently. The younger the patient, the greater the improvement. Patients with normal optic nerve heads improved by 1.54 dB, whereas patients with optic-nerve-head excavation improved by only 0.66 dB. No response was observed in patients with anterior ischemic neuropathy. Marked deterioration was noted in one glaucoma patient with low systemic blood pressure. The visual-field changes were observed in the scotomatous and non-scotomatous areas. Thus, the calcium-channel blocker nifedipine can be effective in some selected diseases whose pathogenesis probably involves vascular dysregulation though it may even be contraindicated in others

The Association between Glaucomatous Visual Fields and Optic Nerve Head Features in the Ocular Hypertension Treatment Study

Ophthalmology ◽  
2006 ◽  
Vol 113 (9) ◽  
pp. 1603-1612 ◽  
Author(s):  
J KELTNER ◽  
C JOHNSON ◽  
D ANDERSON ◽  
R LEVINE ◽  
J FAN ◽  
...  
Keyword(s):  
Optic Nerve ◽  
Ocular Hypertension ◽  
Optic Nerve Head ◽  
Visual Fields ◽  
Hypertension Treatment

scholarly journals An Overview of Glaucoma: Bidirectional Translation between Humans and Pre-Clinical Animal Models

2021 ◽  
Author(s):  
Sophie Pilkinton ◽  
T.J. Hollingsworth ◽  
Brian Jerkins ◽  
Monica M. Jablonski
Keyword(s):  
Risk Factor ◽  
Intraocular Pressure ◽  
Optic Nerve ◽  
Animal Models ◽  
Retinal Ganglion Cells ◽  
Optic Nerve Head ◽  
Ganglion Cells ◽  
Treatment Modalities ◽  
Retinal Ganglion ◽  
Glaucomatous Damage

Glaucoma is a multifactorial, polygenetic disease with a shared outcome of loss of retinal ganglion cells and their axons, which ultimately results in blindness. The most common risk factor of this disease is elevated intraocular pressure (IOP), although many glaucoma patients have IOPs within the normal physiological range. Throughout disease progression, glial cells in the optic nerve head respond to glaucomatous changes, resulting in glial scar formation as a reaction to injury. This chapter overviews glaucoma as it affects humans and the quest to generate animal models of glaucoma so that we can better understand the pathophysiology of this disease and develop targeted therapies to slow or reverse glaucomatous damage. This chapter then reviews treatment modalities of glaucoma. Revealed herein is the lack of non-IOP-related modalities in the treatment of glaucoma. This finding supports the use of animal models in understanding the development of glaucoma pathophysiology and treatments.

scholarly journals The new advantages and perspectives of Latanoprost (Xalatan, Pfizer, USA) treatment in pseudoexfoliation glaucoma

2013 ◽  
Vol 6 (1) ◽  
pp. 61-65
Author(s):  
Nataliya Ivanovna Kurysheva
Keyword(s):  
Optic Nerve ◽  
Optic Nerve Head ◽  
Visual Fields ◽  
Reduction Rate ◽  
Morphometric Parameters ◽  
Therapeutic Activity ◽  
Pseudoexfoliation Glaucoma ◽  
First Choice ◽  
One Year ◽  
The One

The purpose of this study was to compare Latanoprost and Timolol therapeutic activity in pseudoexfoliation glaucoma (PEG). Forty patients with moderate PEG aged from 62 до 78 were enrolled. The one year treatment included the instillation of one drop of Latanoprost 0.005 % once a day (20 patients) and Timololmaleat 0.5 % twice a day (20 patients). The IOP reduction rate in six months was 22 % and 17 % respectively for Latanoprost and Timolol and in twelve months — 17 % and 13 % respectively. The improvement of visual fields and morphometric parameters in Latanoprost group was observed in twelve months: the changes of perimetric indexes from –5.8 ± 0.23 dB to –4.6±1.18 dB (MD) and from 7.3 ± 0.19 dB to 3.8 ± 0.14 dB (PSD); the cup volume of optic nerve head was reduced significantly: from 0.31 ± 0.13 мм3 to 0.21 ± 0.15 мм3. In contrast to this in Timolol group the parameters have become worse: for rim volume this change was: from 0.25 ± 0.14 мм3 до 0.19 ± 0.08 мм3 and for perimetric indexMD: from 5.30.13 dB to 7.8 ± 0.35 dB. We concluded that Latanoprostmay be recommended as the first choice therapy in PEG.

The Effect of Nonlinear Scleral Properties on Optic Nerve Head Biomechanics

2007 ◽  
Author(s):  
Armin Eilaghi ◽  
Ian A. Sigal ◽  
Christian G. Olesen ◽  
Inka Tertinegg ◽  
John G. Flanagan ◽  
...  
Keyword(s):  
Intraocular Pressure ◽  
Optic Nerve ◽  
Optic Nerve Head ◽  
Progressive Damage ◽  
Ocular Diseases ◽  
Glaucomatous Damage ◽  
Elevated Intraocular Pressure ◽  
Biomechanical Factors

Glaucoma is a group of potentially blinding ocular diseases caused by gradual and progressive damage to the optic nerve, and is usually associated with elevated intraocular pressure (IOP) [1]. This damage occurs at the optic nerve head (ONH), the site where the optic nerve axons leave the posterior eye. IOP-related biomechanical factors are hypothesized to play a key role in the pathogenesis of glaucomatous damage [2].

Optic nerve head-related visual fields

1995 ◽  
Vol 15 (6) ◽  
pp. 337-344 ◽  
Author(s):  
Hedwig J. Kaiser ◽  
Josef Flammer
Keyword(s):  
Optic Nerve ◽  
Optic Nerve Head ◽  
Visual Fields

scholarly journals Comparison of Structural Defects between Optic Disc and Ganglion Cell Complex in Patients with Glaucoma

2019 ◽  
pp. 1-7
Author(s):  
Ilias Georgalas ◽  
Sergios Taliantzis ◽  
Maria Kazaki ◽  
Eva Papaconstantinou ◽  
Elina Panagiotopoulou ◽  
...  
Keyword(s):  
Optic Nerve ◽  
Ganglion Cell ◽  
Optic Disc ◽  
Optic Nerve Head ◽  
Cell Complex ◽  
The Other ◽  
Optic Disk ◽  
Structural Defects ◽  
Ganglion Cell Complex ◽  
Glaucomatous Damage

Purpose: To evaluate the agreement of glaucomatous structural defects of the ganglion cell complex (GCC) detected with the spectral domain optical coherence tomography (sdOCT) with the optic nerve head alterations detected with the Heidelberg retina tomography (HRT), of glaucoma patients with ocular hypertension or open angle glaucoma. Material and Methods: Ninety patients eyes with structural glaucomatous defects were enrolled. All of them underwent imaging examination of GCC with sdOCT and the optic disk with HRT. The Cohen's kappa coefficient of agreement was used. Results: The agreement between the optic disc and GCC using the parameters of the programs analysis of the HRT, the moorfields regression analysis (MRA) and glaucoma probability score (GPS) was not significant. Instead between MRA and GPS a good agreement was calculated. Significant agreements were found between MRA and GPS on one hand and GCC on the other, considering location and length of the glaucomatous damage, while non significant agreements were found between GPS and GCC for the location and the length of the glaucomatous structural defect. Conclusions: There is no significance (Please explain further if you are referring to significance in terms of the difference, similarity or agreement) between HRT and sdOCT for the detection of the glaucomatous damage between the optic nerve head and the ganglion cell complex. Instead MRA and GCC detect comparable areas and lengths of the glaucomatous damage. On the other hand GPS records larger deficits relative to MRA and has not a significant agreement with the study of GCC.

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