Topical Nerve Growth Factor for the Treatment of Neurotrophic Keratopathy Caused by Wallenberg Syndrome

Cornea ◽  
2021 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Erika Mandarà ◽  
Daniele Brocca ◽  
Francesco Pellegrini ◽  
Emanuela Interlandi
Keyword(s):  
Nerve Growth Factor ◽  
Growth Factor ◽  
Nerve Growth ◽  
Wallenberg Syndrome ◽  
Neurotrophic Keratopathy

In Vivo Evaluation of Corneal Nerves and Epithelial Healing After Treatment With Recombinant Nerve Growth Factor for Neurotrophic Keratopathy

2020 ◽  
Vol 217 ◽  
pp. 278-286 ◽  
Author(s):  
Leonardo Mastropasqua ◽  
Manuela Lanzini ◽  
Harminder Sing Dua ◽  
Alessandro D' Uffizi ◽  
Marta Di Nicola ◽  
...  
Keyword(s):  
Nerve Growth Factor ◽  
Growth Factor ◽  
In Vivo Evaluation ◽  
Nerve Growth ◽  
Corneal Nerves ◽  
Neurotrophic Keratopathy ◽  
Epithelial Healing

scholarly journals Topical Recombinant Human Nerve Growth Factor (Cenegermin) for Neurotrophic Keratopathy

Ophthalmology ◽  
2020 ◽  
Vol 127 (1) ◽  
pp. 14-26 ◽  
Author(s):  
Stephen C. Pflugfelder ◽  
Mina Massaro-Giordano ◽  
Victor L. Perez ◽  
Pedram Hamrah ◽  
Sophie X. Deng ◽  
...  
Keyword(s):  
Nerve Growth Factor ◽  
Growth Factor ◽  
Nerve Growth ◽  
Human Nerve ◽  
Neurotrophic Keratopathy

Human recombinant nerve growth factor (Cenegermin) in a patient affected by primary congenital glaucoma with neurotrophic keratopathy

2021 ◽  
pp. 112067212199934
Author(s):  
Ivano Riva ◽  
Eleonora Micheletti ◽  
Riccardo Fausto ◽  
Carlo Bruttini ◽  
Giovanni De Angelis ◽  
...  
Keyword(s):  
Nerve Growth Factor ◽  
Growth Factor ◽  
Congenital Glaucoma ◽  
Eye Drops ◽  
Nerve Growth ◽  
Primary Congenital Glaucoma ◽  
Complete Restoration ◽  
New Treatment ◽  
The Right ◽  
Neurotrophic Keratopathy

Purpose: To report a case of neurotrophic keratopathy (NK) in a patient affected by primary congenital glaucoma (PCG) who undergone glaucoma drainage implant surgery. NK was successfully treated with human recombinant Nerve Growth Factor (Cenegermin) eye drops. Case report description: A 46-years-old patient affected by primary congenital glaucoma underwent Ahmed glaucoma valve implantation in the right eye, after several unsuccessful surgeries to control intraocular pressure (IOP) since the age of three. Surgical intervention was performed without complications, and IOP was well-controlled post-operatively. However, 1 month after surgery, he developed NK with stromal ulceration, initially treated with a topical combination of preservative-free artificial tears and antibiotic ointment. As NK did not resolve, a new treatment with Cenegermin 20 µg/ml eye drops, 6 times daily, was started. Outcome: NK completely resolved after 8 weeks of Cenegermin treatment, with complete restoration of corneal integrity and improvement of corneal sensitivity and transparency. Visual acuity in the operated eye reverted to the pre-operative value. Conclusion: Cenegermin was extremely effective in restoring corneal integrity in this PCG patient with NK.

Pediatric Use of Recombinant Human Nerve Growth Factor 20 μg/mL Eye Drops (Cenegermin) for Bilateral Neurotrophic Keratopathy in Congenital Corneal Anesthesia

Cornea ◽  
2020 ◽  
Vol 40 (2) ◽  
pp. 228-231
Author(s):  
Marco G. Leto ◽  
Maria E. Toro ◽  
Patricia E. Indemini ◽  
Claudia Fruttero ◽  
Marco Denina ◽  
...  
Keyword(s):  
Nerve Growth Factor ◽  
Growth Factor ◽  
Eye Drops ◽  
Nerve Growth ◽  
Pediatric Use ◽  
Human Nerve ◽  
Neurotrophic Keratopathy ◽  
Factor 20

Screening Natural Products for Effects on Nerve Growth Factor (NGF) Stimulated Neuritogenesis and Neuritic Outgrowth

Planta Medica ◽  
2011 ◽  
Vol 77 (05) ◽  
Author(s):  
ND Chaurasiya ◽  
R Sahu ◽  
V Samoylenko ◽  
M Ilias ◽  
LA Walker ◽  
...  
Keyword(s):  
Natural Products ◽  
Nerve Growth Factor ◽  
Growth Factor ◽  
Nerve Growth ◽  
Neuritic Outgrowth

Nerve Growth Factor overexpression in Clara cells suppresses metastasis and tumor growth in a mouse model of experimental lung metastasis

Pneumologie ◽  
2012 ◽  
Vol 66 (06) ◽  
Author(s):  
K Seidler ◽  
A Sydykov ◽  
S Müller-Brüsselbach ◽  
R Müller ◽  
N Weißmann ◽  
...  
Keyword(s):  
Nerve Growth Factor ◽  
Growth Factor ◽  
Mouse Model ◽  
Tumor Growth ◽  
Lung Metastasis ◽  
Clara Cells ◽  
Nerve Growth

Degenerating and Painful Human Intervertebral Discs Release Pronociceptive Factors and Increase Neurite Sprouting and CGRP via Nerve Growth Factor

2014 ◽  
Vol 4 (1_suppl) ◽  
pp. s-0034-1376539-s-0034-1376539
Author(s):  
E. Krock ◽  
D. H. Rosenzweig ◽  
A. J. Chabot-Dore ◽  
P. Jarzem ◽  
M. H. Weber ◽  
...  
Keyword(s):  
Nerve Growth Factor ◽  
Growth Factor ◽  
Intervertebral Discs ◽  
Nerve Growth
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