Platelet-Rich Plasma and Deproteinized Bovine Bone Matrix in Maxillary Sinus Lift Surgery

Sinus lift operations have become a prerequisite for implantologists in the rehabilitation of atrophic posterior maxilla. Alloplasts and xenografts are the recent innovation in the world of grafting materials and have evolved in such a way as to compensate the need for autografts to be used in conjunction. In order to perfect the grafting materials, histomorphometry is the most often tool used to study the success of the augmentation. This article has tried to commemorate the importance of histomorphometry in maxillary antroplasty and also the success rate of β-tricalciumphosphate and deproteinized bovine bone as an augmentation material in maxillary augmentation.

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Maxillary sinus lift response to platelet-rich plasma associated with autogenous bone, ceramic biphasic HA/β-TCP (70:30), or deproteinized bovine bone

International Journal of Implant Dentistry ◽

10.1186/s40729-020-00277-9 ◽

2020 ◽

Vol 6 (1) ◽

Author(s):

Caroline Andrade Rocha ◽

Ricardo Vinicius Nunes Arantes ◽

Tania Mary Cestari ◽

Paula Sanches Santos ◽

Gerson Francisco Assis ◽

...

Keyword(s):

Bone Formation ◽

Maxillary Sinus ◽

Soft Tissues ◽

Platelet Rich Plasma ◽

Blood Clot ◽

Autogenous Bone ◽

Bovine Bone ◽

Long Term Effects ◽

Sinus Augmentation ◽

Deproteinized Bovine Bone

Abstract Background This study evaluated the long-term effects of platelet-rich plasma (PRP) on bone formation and regeneration when associated with autogenous bone graft (AB), porous biphasic calcium phosphate (pBCP), or deproteinized bovine bone (DBB) in maxillary sinus augmentation (MSA) of rabbit. Methods In 54 rabbits, bilateral MSA procedure was performed and randomly one sinus was filled with 200 mm3 material plus blood clot (AB/clot, DBB/clot, and pBCP/clot) and other with the same graft plus PRP (AB/PRP, DBB/PRP, and pBCP/PRP). After 30, 60, and 180 days, microtomographic were performed to analyze the three-dimensional MSA volume and histomorphometric analyses for the percentage of bone and soft tissues ingrowth. Data were compared by two-way ANOVA and the means were compared by the Tukey test, at p < 0.05. Results The percentage of pBCP and DBB were nearly unchanged throughout the whole period and bone formation occurred in the spaces between particles. The MSA volume filled with DBB and pBCP agglutinated with clot and PRP maintained constant during all experimental periods (147.2 mm3 and 154.9 mm3, respectively, p = 0.7377), and no significant changes in the new formatted bone and soft tissue were observed between treatments. In AB/clot and AB/PRP, the MSA volume was similar at 30 days (140.3 mm3 and 137.9 mm3, respectively), but a higher and gradual reduction was observed until 180 days. In the AB/PRP, this reduction was significantly higher (44.2%) than AB/clot (22.5%) (p = 0.01792). Histologically, the addition of PRP to AB accelerated the new bone formation/remodeling maintaining the percentage of new bone similar to AB/clot during all experimental volume (p = 0.6406), while the AB particles showed a higher resorption in AB/PRP than AB/clot until 60 days (mean of 7.8% and 15.1%, respectively, p = 0.0396). Conclusion The association of PRP with the autogenous graft accelerates the process of bone formation/remodeling in MSA, but not had influence on the pBCP and DBB groups.

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