Open Conjunctival Approach for Sub-Tenon’s Xen Gel Stent Placement and Bleb Morphology by Anterior Segment Optical Coherence Tomography

Iris pigment epithelial (IPE) cysts are a subset of iris cysts that arise from the IPE. They are spontaneously erupting epithelial-lined cavities that are found in various anatomic locations of the iris, including the iris pupillary margin, midzone, periphery, and free floating in the vitreous or anterior chamber. We report the case of an asymptomatic 13-year-old boy with an incidental finding of a dislodged anterior chamber cyst diagnosed on routine examination. Modern multimodal image analysis of the cyst including anterior segment optical coherence tomography and ultrasound biomicroscopy (UBM) was utilized to characterize the microstructural anatomy of the lesion. The patient was managed conservatively without complications. Cysts of the IPE typically do not affect vision or ocular health and can be monitored and observed after ascertaining no associated malignancy. Initial diagnostic investigation can include UBM and anterior segment optical coherence tomography. Intervention should be reserved only for cases where the cyst growth leads to obstruction of the visual axis and/or other secondary complications.

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Structural changes of corneal epithelium in belantamab-associated superficial keratopathy using anterior segment optical coherence tomography

American Journal of Ophthalmology Case Reports ◽

10.1016/j.ajoc.2021.101133 ◽

2021 ◽

pp. 101133

Author(s):

Wataru Matsumiya ◽

Irmak Karaca ◽

Hashem Ghoraba ◽

Amir Akhavanrezayat ◽

Azadeh Mobasserian ◽

...

Keyword(s):

Optical Coherence Tomography ◽

Corneal Epithelium ◽

Structural Changes ◽

Anterior Segment ◽

Optical Coherence

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Evaluation of Intraocular Lens Tilt With Anterior Segment Optical Coherence Tomography

American Journal of Ophthalmology ◽

10.1016/j.ajo.2010.09.013 ◽

2011 ◽

Vol 151 (3) ◽

pp. 406-412.e2 ◽

Cited By ~ 29

Author(s):

Dhivya Ashok Kumar ◽

Amar Agarwal ◽

Gaurav Prakash ◽

Soosan Jacob ◽

Yoga Saravanan ◽

...

Keyword(s):

Optical Coherence Tomography ◽

Intraocular Lens ◽

Anterior Segment ◽

Optical Coherence ◽

Intraocular Lens Tilt

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The Use of Anterior-Segment Optical-Coherence Tomography for the Assessment of the Iridocorneal Angle and Its Alterations: Update and Current Evidence

Journal of Clinical Medicine ◽

10.3390/jcm10020231 ◽

2021 ◽

Vol 10 (2) ◽

pp. 231

Author(s):

Giacinto Triolo ◽

Piero Barboni ◽

Giacomo Savini ◽

Francesco De Gaetano ◽

Gaspare Monaco ◽

...

Keyword(s):

Optical Coherence Tomography ◽

Intraocular Pressure ◽

Clinical Relevance ◽

Anterior Segment ◽

Angle Closure ◽

Current Evidence ◽

Optical Coherence ◽

Iridocorneal Angle ◽

Wide Range

The introduction of anterior-segment optical-coherence tomography (AS-OCT) has led to improved assessments of the anatomy of the iridocorneal-angle and diagnoses of several mechanisms of angle closure which often result in raised intraocular pressure (IOP). Continuous advancements in AS-OCT technology and software, along with an extensive research in the field, have resulted in a wide range of possible parameters that may be used to diagnose and follow up on patients with this spectrum of diseases. However, the clinical relevance of such variables needs to be explored thoroughly. The aim of the present review is to summarize the current evidence supporting the use of AS-OCT for the diagnosis and follow-up of several iridocorneal-angle and anterior-chamber alterations, focusing on the advantages and downsides of this technology.

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Non-malignant conjunctival epithelial masses with ocular surface squamous neoplasia-like optical coherence tomography features

International Ophthalmology ◽

10.1007/s10792-021-01743-y ◽

2021 ◽

Author(s):

Ágnes Füst ◽

Jeannette Tóth ◽

László Imre ◽

Zoltán Zsolt Nagy

Keyword(s):

Optical Coherence Tomography ◽

Ocular Surface ◽

Anterior Segment ◽

Histological Diagnosis ◽

Optical Coherence ◽

Ocular Surface Squamous Neoplasia ◽

Ocular Coherence Tomography ◽

Maximal Thickness ◽

Epithelial Lesions ◽

Mass Lesions

Abstract Purpose To observe and describe the anterior segment optical coherence tomography features of limbally localised non-malignant epithelial mass lesions Methods Thirteen patients (age: 66.9 ± 16.3 years) with conjunctival mass suggesting ocular surface squamous neoplasia with biomicroscopic examination were imaged using anterior segment ocular coherence tomography (anterior segment optical coherence tomography)/Cirrus HD-OCT, Model 4000, Carl Zeiss Meditec, Inc., Dublin, CA, and Spectralis HRA + OCT system, Heidelberg Engineering, Vista, CA/. Cases with ocular surface squamous neoplasia-like anterior segment optical coherence tomography (hyperreflective, thickened epithelium and an abrupt transition from normal to abnormal) were included in the study. Maximal thickness of the epithelium was measured. Histological diagnosis was gained from an excisional or incisional biopsy or impression cytology specimens. Results In six patients (age: 68.5 ± 15.4 years) with ocular surface squamous neoplasia-like anterior segment optical coherence tomography features, the histological diagnosis was other than ocular surface squamous neoplasia (papilloma, parakeratosis and a keratotic plaque with mild dysplasia), and ocular surface squamous neoplasia in seven cases (age: 65.6 ± 18.0 years). The maximal epithelial thickness was between 250 and 859 µm in non-ocular surface squamous neoplasia cases and between 252 and 596 µm in ocular surface squamous neoplasia cases. Conclusion Non-malignant epithelial lesions can mimic ocular surface squamous neoplasia on anterior segment optical coherence tomography.

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Diagnosing Paraproteinemic Keratopathy: A Case Report

Case Reports in Ophthalmology ◽

10.1159/000514375 ◽

2021 ◽

pp. 337-343

Author(s):

Eugenie Mok ◽

Ka Wai Kam ◽

Anthony J. Aldave ◽

Alvin L. Young

Keyword(s):

Optical Coherence Tomography ◽

Genetic Testing ◽

Serum Protein ◽

Molecular Genetic ◽

Anterior Segment ◽

Protein Electrophoresis ◽

Serum Protein Electrophoresis ◽

Optical Coherence ◽

Molecular Genetic Testing ◽

Corneal Opacities

A 65-year-old man presented with bilateral, painless, progressive blurring of vision over 9 years. Slit-lamp examination revealed bilateral subepithelial corneal opacities in clusters located at the mid-periphery. Anterior segment optical coherence tomography, in vivo confocal microscopy (IVCM), serum protein electrophoresis, and molecular genetic testing were performed to evaluate the cause of corneal opacities. Anterior segment optical coherence tomography revealed a band-like, hyperreflective lesion in the Bowman layer and anterior stroma of both corneas. IVCM revealed hyperreflective deposits in the epithelium, anterior stroma, and endothelium. Serum protein electrophoresis identified the presence of paraproteins (immunoglobulin kappa), and molecular genetic testing revealed absence of mutations in the transforming growth factor beta-induced gene (<i>TGFBI</i>) and collagen type XVII alpha 1 gene (<i>COL17A1</i>). The ocular diagnosis of paraproteinemic keratopathy eventually led to a systemic diagnosis of monoclonal gammopathy of undetermined significance by our hematologist/oncologist. Paraproteinemic keratopathy is a rare differential diagnosis in patients with bilateral corneal opacities and therefore may be misdiagnosed as corneal dystrophy or neglected as scars. In patients with bilateral corneal opacities of unknown cause, serological examination, adjunct anterior segment imaging, and molecular genetic testing play a role in establishing the diagnosis.

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