scholarly journals Structural changes of corneal epithelium in belantamab-associated superficial keratopathy using anterior segment optical coherence tomography

2021 ◽  
pp. 101133
Author(s):  
Wataru Matsumiya ◽  
Irmak Karaca ◽  
Hashem Ghoraba ◽  
Amir Akhavanrezayat ◽  
Azadeh Mobasserian ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Corneal Epithelium ◽  
Structural Changes ◽  
Anterior Segment ◽  
Optical Coherence

Changes in Langerhans cells and the structure of corneal nerve fibers in patients with glaucoma according in vivo confocal microscopy

2021 ◽  
pp. 30-32
Author(s):  
S.E. Avetisov ◽  
◽  
V.V. Strahov ◽  
Z.V. Surnina ◽  
A.A. Popova ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Confocal Microscopy ◽  
Langerhans Cells ◽  
Structural Changes ◽  
Open Angle Glaucoma ◽  
Anterior Segment ◽  
Nerve Fibers ◽  
Control Group ◽  
Optical Coherence ◽  
Corneal Nerve

The most important tasks of preventing blindness and low vision in primary open-angle glaucoma (POAG) are its early diagnosis and quality monitoring in order to stabilize the glaucoma process. Purpose. To analyze the state of Langerhans inflammatory cells and the structure of corneal nerve fibers in patients with POAG. Material and methods. The study included 46 patients. The main group - 26 patients (52 eyes) aged 39 to 80 years - diagnosed with POAG stages I-IV. Control group - 20 patients (40 eyes) - ophthalmologically healthy volunteers with a normal level of intraocular pressure (IOP) and no signs of POAG at the age from 36 to 72 years. Patients underwent: visometry, biomicroscopy of the anterior segment of the eye, ophthalmoscopy, gonioscopy, contour tonometry using the Pascal method, optical coherence tomography (OCT) of the optic nerve discs (Zeiss Stratus 3000) and confocal microscopy of the cornea (CMR) (HRT III, Rostock Cornea Module). Results. In patients with POAG, according to CMR data, structural changes were revealed in the layer of nerve fibers of the cornea, and abnormalities in the structure and number of inflammatory macrophages (Langerhans cells) were also identified. The interocular asymmetry of CNF was investigated in patients with different stages of glaucoma in paired eyes. Conclusion. Аnalyzing the structure of corneal nerve fibers and Langerhans cells can be used as a diagnostic algorithm in patients with POAG. Key words: glaucoma, confocal microscopy, corneal nerve fibers, Langerhans cells, optical coherence tomography.

scholarly journals Anterior segment optical coherence tomography evaluation of corneal epithelium healing time after 2 different surface ablation methods

2015 ◽  
Vol 36 (1) ◽  
pp. 67-72 ◽  
Author(s):  
Mustafa Eliaçik ◽  
Hüseyin Bayramlar ◽  
Sevil Erdur ◽  
Yunus Karabela ◽  
Göktuğ Demirci ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Corneal Epithelium ◽  
Anterior Segment ◽  
Healing Time ◽  
Optical Coherence ◽  
Surface Ablation

Spectral-Domain Optical Coherence Tomography Imaging in Peripheral Ulcerative Keratitis. A Corneal Structural Description

2020 ◽  
Author(s):  
Clemence BONNET ◽  
Louis Debillon ◽  
Saba Al-Hashimi ◽  
Florence Hoogewoud ◽  
Dominique Monnet ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Structural Changes ◽  
Systemic Vasculitis ◽  
Anterior Segment ◽  
Case Series ◽  
Acute Stage ◽  
Structural Description ◽  
Optical Coherence ◽  
Peripheral Ulcerative Keratitis ◽  
Ulcerative Keratitis

Abstract Background: Anterior-segment optical coherence tomography (AS-OCT) is an important tool, helpful to diagnose and manage many corneal conditions, but has not been reported in cases of peripheral ulcerative keratitis (PUK). The aim of this study is to describe AS-OCT findingsin cases of PUK.Methods: Retrospective observational case series of six eyes with a PUK with proven systemic vasculitis. Clinical course, slit-lamp photographs, and AS-OCT findings were the main outcomes.Results: The AS-OCT findings were found to correlate with the ocular disease’s level of activity. In the acute stage, an absence of corneal epithelium, a scrambled appearance of the anterior stroma and a heterogeneous stromal reflectivity were observed. During the reduction of disease level activity, an irregular hyporeflective epithelium, a smoother anterior stroma, and a homogenous hyperreflective stroma were seen. At the healed stage, a filling of the corneal defect by a hyporeflective thick epithelium, the persistence of the hyperreflective underlying stroma, and a demarcation line were observed.Conclusions: AS-OCT provides an assessment of structural changes occurring in PUK, useful for its diagnosis and monitoring.

scholarly journals In Vivo Confocal Microscopy and Anterior Segment Optical Coherence Tomography Analysis of the Microcystic Keratitis

2020 ◽  
Vol 2020 ◽  
pp. 1-6
Author(s):  
Michał Dembski ◽  
Anna Nowińska ◽  
Klaudia Ulfik ◽  
Sławomir Teper ◽  
Edward Wylęgała
Keyword(s):  
Optical Coherence Tomography ◽  
Epithelial Cells ◽  
Confocal Microscopy ◽  
Corneal Epithelium ◽  
Anterior Segment ◽  
Corneal Stroma ◽  
Acute Stage ◽  
Optical Coherence ◽  
In Vivo Confocal Microscopy

Purpose. To describe the findings of in vivo confocal microscopy (IVCM) and anterior segment optical coherence tomography (AS-OCT) in a case of bilateral acute microcystic epitheliopathy after daily soft contact lens wear. Methods. IVCM and AS-OCT were used in the course of the bilateral epitheliopathy of a 23-year-old patient at the acute stage of the disease and at recovery after four days of treatment. The images were analyzed and compared. Results. On AS-OCT of the right eye, general hyperreflectivity and the increased thickness of the central corneal epithelium to 150 μm with numerous hyporeflective small, oval cysts were revealed and resolved completely at day 4 after diagnosis and treatment. AS-OCT scans of the left eye revealed oval shaped, hyperreflective material within the corneal epithelium. IVCM of both eyes showed numerous microcysts of different sizes filled with hyperreflective material mostly within superficial epithelial layers. Epithelial cells showed a polymorphism along with disruption of a cytoarchitecture. Basal epithelial cells and anterior stroma showed inflammatory changes. Posterior corneal stroma and endothelium presented normal morphology. Conclusions. Microcystic keratitis appeared as localized microcystic inflammation of epithelium on AS-OCT, which was confirmed by IVCM. Both IVCM and AS-OCT are helpful diagnostic instruments in case of cystic inflammation of corneal epithelium.

Utility of the Anterior Segment Optical Coherence Tomography for Measurements of Central Corneal Thickness

2007 ◽  
Vol 48 (12) ◽  
pp. 1643 ◽  
Author(s):  
Hyoung Sub Shim ◽  
Chul Young Choi ◽  
Hee Gyung Lee ◽  
Myoung Joon Kim ◽  
Hung Won Tchah
Keyword(s):  
Optical Coherence Tomography ◽  
Central Corneal Thickness ◽  
Corneal Thickness ◽  
Anterior Segment ◽  
Optical Coherence

Pediatric Free-floating Anterior Chamber Cyst of the Iris Pigment Epithelium

2018 ◽  
Vol 1 ◽  
pp. 3
Author(s):  
Joshua S Agranat ◽  
Yoshihiro Yonekawa
Keyword(s):  
Optical Coherence Tomography ◽  
Anterior Chamber ◽  
Incidental Finding ◽  
Pigment Epithelium ◽  
Anterior Segment ◽  
Ultrasound Biomicroscopy ◽  
Optical Coherence ◽  
Visual Axis ◽  
Associated Malignancy ◽  
Anatomic Locations

Iris pigment epithelial (IPE) cysts are a subset of iris cysts that arise from the IPE. They are spontaneously erupting epithelial-lined cavities that are found in various anatomic locations of the iris, including the iris pupillary margin, midzone, periphery, and free floating in the vitreous or anterior chamber. We report the case of an asymptomatic 13-year-old boy with an incidental finding of a dislodged anterior chamber cyst diagnosed on routine examination. Modern multimodal image analysis of the cyst including anterior segment optical coherence tomography and ultrasound biomicroscopy (UBM) was utilized to characterize the microstructural anatomy of the lesion. The patient was managed conservatively without complications. Cysts of the IPE typically do not affect vision or ocular health and can be monitored and observed after ascertaining no associated malignancy. Initial diagnostic investigation can include UBM and anterior segment optical coherence tomography. Intervention should be reserved only for cases where the cyst growth leads to obstruction of the visual axis and/or other secondary complications.

Evaluation of Intraocular Lens Tilt With Anterior Segment Optical Coherence Tomography

2011 ◽  
Vol 151 (3) ◽  
pp. 406-412.e2 ◽  
Author(s):  
Dhivya Ashok Kumar ◽  
Amar Agarwal ◽  
Gaurav Prakash ◽  
Soosan Jacob ◽  
Yoga Saravanan ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Intraocular Lens ◽  
Anterior Segment ◽  
Optical Coherence ◽  
Intraocular Lens Tilt

scholarly journals The Use of Anterior-Segment Optical-Coherence Tomography for the Assessment of the Iridocorneal Angle and Its Alterations: Update and Current Evidence

2021 ◽  
Vol 10 (2) ◽  
pp. 231
Author(s):  
Giacinto Triolo ◽  
Piero Barboni ◽  
Giacomo Savini ◽  
Francesco De Gaetano ◽  
Gaspare Monaco ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Intraocular Pressure ◽  
Clinical Relevance ◽  
Anterior Segment ◽  
Angle Closure ◽  
Current Evidence ◽  
Optical Coherence ◽  
Iridocorneal Angle ◽  
Wide Range

The introduction of anterior-segment optical-coherence tomography (AS-OCT) has led to improved assessments of the anatomy of the iridocorneal-angle and diagnoses of several mechanisms of angle closure which often result in raised intraocular pressure (IOP). Continuous advancements in AS-OCT technology and software, along with an extensive research in the field, have resulted in a wide range of possible parameters that may be used to diagnose and follow up on patients with this spectrum of diseases. However, the clinical relevance of such variables needs to be explored thoroughly. The aim of the present review is to summarize the current evidence supporting the use of AS-OCT for the diagnosis and follow-up of several iridocorneal-angle and anterior-chamber alterations, focusing on the advantages and downsides of this technology.

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