scholarly journals Prurigo pigmentosa: a case with rapid response to doxycycline and the likely pathogenetic role of neutrophils

Itch ◽  
2021 ◽  
Vol 6 (4) ◽  
pp. e51-e51
Author(s):  
Laura L.Y. Hui ◽  
Joyce S.S. Lee ◽  
Hong Liang Tey
Keyword(s):  
Rapid Response ◽  
Pathogenetic Role

Histopathological Proof of the Pathogenetic Role of a Rare GFAP Mutation in Alexander´s Disease with Isolated Flaccid Paraparesis

2017 ◽  
Vol 48 (S 01) ◽  
pp. S1-S45
Author(s):  
F. Brackmann ◽  
R. Coras ◽  
K. Rössler ◽  
O. Rompel ◽  
R. Trollmann
Keyword(s):  
Pathogenetic Role

Imbalance in the system L-arginin-NO in pathogenesis of obstetric complications and intrauterine growth retardation (Literature review)

2016 ◽  
pp. 43-47
Author(s):  
O.V. Basystyi ◽  
Keyword(s):  
Nitric Oxide ◽  
Literature Review ◽  
Growth Retardation ◽  
Intrauterine Growth Retardation ◽  
Obstetric Complications ◽  
Pathogenetic Role ◽  
Intrauterine Growth ◽  
System L ◽  
Nitric Oxide Deficiency

The data of domestic and foreign literature on etiology, pathogenesis and intrauterine growth retardation diagnosis are presented in the paper. It highlights pathogenetic role of nitric oxide deficiency in case of obstetric complications and intrauterine growth retardation. Key words: intrauterine growth retardation (IUGR), system L-arginin–NO, obstetric complications.

Pathogenetic role of Campylobacter pyloridis in gastric ulcer

1987 ◽  
Vol 2 (4) ◽  
pp. 309-316 ◽  
Author(s):  
WAI-MO HUI ◽  
SHIU-KUM LAM ◽  
PAT-YIM CHAU ◽  
JOANA HO ◽  
WAN-YEE LAU ◽  
...  
Keyword(s):  
Gastric Ulcer ◽  
Pathogenetic Role ◽  
Campylobacter Pyloridis

scholarly journals NKCC1 and NKCC2: The pathogenetic role of cation-chloride cotransporters in hypertension

2015 ◽  
Vol 2 (2) ◽  
pp. 186-196 ◽  
Author(s):  
Sergei N. Orlov ◽  
Svetlana V. Koltsova ◽  
Leonid V. Kapilevich ◽  
Svetlana V. Gusakova ◽  
Nickolai O. Dulin
Keyword(s):  
Pathogenetic Role ◽  
Cation Chloride Cotransporters

Clinical and pathogenetic role of state of prooxidant-antioxidant regulation in patients with purulent meningitis in the dynamics of disease

2014 ◽  
Vol 18 (4 (72)) ◽  
Author(s):  
D. A. Zadyraka ◽  
E. V. Riabokon
Keyword(s):  
Free Radical ◽  
Conventional Treatment ◽  
Free Radical Oxidation ◽  
Oxidative Modification ◽  
Blood Proteins ◽  
Radical Oxidation ◽  
Pathogenetic Role ◽  
Purulent Meningitis ◽  
Laboratory Changes

The paper shows, that patients with purulent meningitis on the background of severe clinical and laboratory changes had a disturbance of prooxidant-antioxidant regulation with a shift towards activation of free radical oxidation. In the dynamics of the disease, after 7-10 days of conventional treatment, against the background of a reduction of cephalic and meningeal syndromes intensity, a normalization of liquor and hemogram indices, in most patients there was a further decrease in catalase activity and an increase of nitrites, of parameters of spontaneous and induced oxidative modification of blood proteins that remained when the patients were discharged, compared with healthy people.

scholarly journals The Prospects of Succinates’ Use under Hypoxic Conditions in COVID-19

2021 ◽  
Vol 66 (1-2) ◽  
pp. 65-74
Author(s):  
Yu. Р. Orlov ◽  
V. V. Afanasyev ◽  
I. A. Khilenko
Keyword(s):  
Clinical Studies ◽  
Multiple Organ ◽  
Tissue Hypoxia ◽  
Diaphragmatic Dysfunction ◽  
Pathogenetic Role ◽  
Domestic Literature ◽  
Hypoxic Conditions ◽  
Number Of Patients ◽  
Positive Effect

The aim of the work was the search for materials from experimental and clinical studies reflecting the pathogenetic role of the possible use of succinates for the correction of hypoxia in COVID-19. Materials and methods. 79 foreign and domestic literature sources were analyzed concerning the pathogenesis of COVID-19 and the pathogenetic role of succinates in hypoxia under conditions of COVID-19, oxidative stress, and diaphragmatic dysfunction were analyzed. The literature search was carried out using Pubmed and ELIBRARY.ru databases. Results. As the analysis of the literature has shown, tissue hypoxia is the basis of COVID-19 pathogenesis, triggering the entire cascade of  pathomorphological events leading to the development of multiple organ failure. A number of experimental and clinical studies (on a fairly large number of patients) reflect the positive effect of tissue hypoxia correction using succinates, both in adult patients and in children with a different spectrum of pathology associated with acute respiratory failure syndrome. Conclusion. Analysis of literature data allows to substantiate the prospect of using preparations containing succinate (reamberin, cytoflavin) in the complex therapy of severe cases of COVID-19. 

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