Association of Brachial-Ankle Pulse Wave Velocity, Ankle-Brachial Index and Ratio of Brachial Pre-Ejection Period to Ejection Time With Left Ventricular Hypertrophy

2014 ◽  
Vol 347 (4) ◽  
pp. 289-294 ◽  
Author(s):  
Ho-Ming Su ◽  
Po-Chao Hsu ◽  
Wen-Hsien Lee ◽  
Szu-Chia Chen ◽  
Tsung-Hsien Lin ◽  
...  
Keyword(s):  
Left Ventricular Hypertrophy ◽  
Pulse Wave Velocity ◽  
Wave Velocity ◽  
Ventricular Hypertrophy ◽  
Pulse Wave ◽  
Ankle Brachial Index ◽  
Left Ventricular ◽  
Ejection Time

scholarly journals Noninvasive Brachial-Ankle Pulse Wave Velocity in Hypertensive Patients With Left Ventricular Hypertrophy

2010 ◽  
Vol 23 (3) ◽  
pp. 269-274 ◽  
Author(s):  
K.-H. Park ◽  
W. J. Park ◽  
M.-K. Kim ◽  
J.-H. Jung ◽  
S. Choi ◽  
...  
Keyword(s):  
Left Ventricular Hypertrophy ◽  
Pulse Wave Velocity ◽  
Wave Velocity ◽  
Ventricular Hypertrophy ◽  
Pulse Wave ◽  
Left Ventricular ◽  
Hypertensive Patients

scholarly journals Elevated Brachial-Ankle Pulse Wave Velocity Is Associated with Left Ventricular Hypertrophy in Hypertensive Patients after Stroke

2010 ◽  
Vol 220 (3) ◽  
pp. 177-182 ◽  
Author(s):  
Hisashi Masugata ◽  
Shoichi Senda ◽  
Jun Hoshikawa ◽  
Koji Murao ◽  
Naohisa Hosomi ◽  
...  
Keyword(s):  
Left Ventricular Hypertrophy ◽  
Pulse Wave Velocity ◽  
Wave Velocity ◽  
Ventricular Hypertrophy ◽  
Pulse Wave ◽  
Left Ventricular ◽  
Hypertensive Patients

A high ankle-brachial index is associated with increased aortic pulse wave velocity: the Czech post-MONICA study

2011 ◽  
Vol 18 (6) ◽  
pp. 790-796 ◽  
Author(s):  
Peter Wohlfahrt ◽  
Daniel Palouš ◽  
Michaela Ingrischová ◽  
Alena Krajčoviechová ◽  
Jitka Seidlerová ◽  
...  
Keyword(s):  
Cardiovascular Risk ◽  
Pulse Wave Velocity ◽  
Wave Velocity ◽  
Aortic Stiffness ◽  
Pulse Wave ◽  
Population Sample ◽  
Ankle Brachial Index ◽  
Aortic Pulse Wave Velocity ◽  
Left Ventricular ◽  
History Of

Background: Ankle brachial index (ABI) has been increasingly used in general practice to identify individuals with low ABI at high cardiovascular risk. However, there has been no consensus on the clinical significance of high ABI. The aim of our study was to compare aortic stiffness as a marker of cardiovascular risk in individuals with low (<1.0), normal (1.0–1.4), and high ABI (>1.4). Methods: A total of 911 individuals from the Czech post-MONICA study (a randomly selected 1% representative population sample, aged 54 ± 13.5 years, 47% of men) were examined. ABI was measured using a handheld Doppler and aortic pulse wave velocity (aPWV) using the Sphygmocor device. Results: Of the 911 individuals, 28 (3.1%) had low ABI and 23 (2.5%) high ABI. There was a U-shaped association between aPWV and ABI. aPWV was significantly higher in individuals with low and high ABI compared with the normal ABI group (11.1 ± 2.8, 8.3 ± 2.3, p < 0.001; 10.8 ± 2.5, 8.3 ± 2.3 m/s, p < 0.001, respectively). In a model adjusted for age, sex, systolic, diastolic, mean blood pressure and examiner, aPWV remained increased in both extreme ABI groups compared with the normal ABI group. In logistic regression analysis, aPWV together with glucose level, male sex, and a history of deep venous thrombosis were independent predictors of high ABI, while cholesterol was not. Conclusion: This is the first study showing increased aortic stiffness in individuals with high ABI, presumably responsible for increased left ventricular mass described previously in this group. These findings suggest increased cardiovascular risk of high ABI individuals.

Hypertension-Mediated Organ Damage: Prevalence, Correlates, and Prognosis in the Community

Hypertension ◽  
2021 ◽  
Author(s):  
Ramachandran S. Vasan ◽  
Rebecca J. Song ◽  
Vanessa Xanthakis ◽  
Alexa Beiser ◽  
Charles DeCarli ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Pulse Wave Velocity ◽  
Kidney Function ◽  
Wave Velocity ◽  
Pulse Wave ◽  
Disease Risk ◽  
Cardiovascular Disease Risk ◽  
Ankle Brachial Index ◽  
Intima Media Thickness ◽  
Left Ventricular

We characterized the prevalence, correlates, and prognosis of hypertension-mediated organ damage (HMOD) in the community-based Framingham Study. 7898 participants (mean age 51.6 years, 54% women) underwent assessment for the following HMOD: electrocardiographic and echocardiographic left ventricular hypertrophy, abnormal brain imaging findings consistent with vascular injury, increased carotid intima-media thickness, elevated carotid-femoral pulse wave velocity, reduced kidney function, microalbuminuria, and low ankle-brachial index. We characterized HMOD prevalence according to blood pressure (BP) categories defined by four international BP guidelines. Participants were followed up for incidence of cardiovascular disease. The prevalence of HMOD varied positively with systolic BP and pulse pressure but negatively with diastolic BP; it increased with age, was similar in both sexes, and varied across BP guidelines based on their thresholds defining hypertension. Among participants with hypertension, elevated carotid-femoral pulse wave velocity was the most prevalent HMOD (40%–60%), whereas low ankle-brachial index was the least prevalent (<5%). left ventricular hypertrophy, reduced kidney function, microalbuminuria, increased carotid intima-media thickness, and abnormal brain imaging findings had an intermediate prevalence (20%–40%). HMOD frequently clustered within individuals. On follow-up (median, 14.1 years), there were 384 cardiovascular disease events among 5865 participants with concurrent assessment of left ventricular mass, carotid-femoral pulse wave velocity, kidney function, and microalbuminuria. For every BP category above optimal (referent group), the presence of HMOD increased cardiovascular disease risk compared with its absence. The prevalence of HMOD varies across international BP guidelines based on their different thresholds for defining hypertension. The presence of HMOD confers incremental prognostic information regarding cardiovascular disease risk at every BP category.

Left ventricular ejection time, not heart rate, is an independent correlate of aortic pulse wave velocity

2013 ◽  
Vol 115 (11) ◽  
pp. 1610-1617 ◽  
Author(s):  
Paolo Salvi ◽  
Carlo Palombo ◽  
Giovanni Matteo Salvi ◽  
Carlos Labat ◽  
Gianfranco Parati ◽  
...  
Keyword(s):  
Pulse Wave Velocity ◽  
Wave Velocity ◽  
Pulse Wave ◽  
Left Ventricular ◽  
Ventricular Ejection ◽  
Left Ventricular Ejection ◽  
Heart Period ◽  
Ejection Time ◽  
Left Ventricular Ejection Time ◽  
Ventricular Ejection Time

Several studies showed a positive association between heart rate and pulse wave velocity, a sensitive marker of arterial stiffness. However, no study involving a large population has specifically addressed the dependence of pulse wave velocity on different components of the cardiac cycle. The aim of this study was to explore in subjects of different age the link between pulse wave velocity with heart period (the reciprocal of heart rate) and the temporal components of the cardiac cycle such as left ventricular ejection time and diastolic time. Carotid-femoral pulse wave velocity was assessed in 3,020 untreated subjects (1,107 men). Heart period, left ventricular ejection time, diastolic time, and early-systolic dP/dt were determined by carotid pulse wave analysis with high-fidelity applanation tonometry. An inverse association was found between pulse wave velocity and left ventricular ejection time at all ages (<25 years, r2 = 0.043; 25–44 years, r2 = 0.103; 45–64 years, r2 = 0.079; 65–84 years, r2 = 0.044; ≥85 years, r2 = 0.022; P < 0.0001 for all). A significant ( P < 0.0001) negative but always weaker correlation between pulse wave velocity and heart period was also found, with the exception of the youngest subjects ( P = 0.20). A significant positive correlation was also found between pulse wave velocity and dP/dt ( P < 0.0001). With multiple stepwise regression analysis, left ventricular ejection time and dP/dt remained the only determinant of pulse wave velocity at all ages, whereas the contribution of heart period no longer became significant. Our data demonstrate that pulse wave velocity is more closely related to left ventricular systolic function than to heart period. This may have methodological and pathophysiological implications.

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