Macrophage Migration Inhibitory Factor Deficiency Causes Prolonged Hearing Loss After Acoustic Overstimulation

2015 ◽  
Vol 36 (6) ◽  
pp. 1103-1108 ◽  
Author(s):  
Shin Kariya ◽  
Mitsuhiro Okano ◽  
Yukihide Maeda ◽  
Haruka Hirai ◽  
Takaya Higaki ◽  
...  
Keyword(s):  
Hearing Loss ◽  
Migration Inhibitory Factor ◽  
Macrophage Migration Inhibitory Factor ◽  
Inhibitory Factor ◽  
Macrophage Migration ◽  
Factor Deficiency ◽  
Acoustic Overstimulation

Association between Macrophage Migration Inhibitory Factor Gene Variation and Response to Glucocorticoid Treatment in Sudden Sensorineural Hearing Loss

2015 ◽  
Vol 20 (6) ◽  
pp. 376-382 ◽  
Author(s):  
Nasrin Yazdani ◽  
Armita Kakavand Hamidi ◽  
Hossein Ghazavi ◽  
Mohammad Javad Rikhtegar ◽  
Masoud Motesadi Zarandi ◽  
...  
Keyword(s):  
Hearing Loss ◽  
Sensorineural Hearing Loss ◽  
Migration Inhibitory Factor ◽  
Macrophage Migration Inhibitory Factor ◽  
Sudden Sensorineural Hearing Loss ◽  
Sensorineural Hearing ◽  
Inhibitory Factor ◽  
Response To Treatment ◽  
Macrophage Migration ◽  
Glucocorticoid Treatment

Several lines of evidence suggest the role of the immune system in the pathogenesis of sudden sensorineural hearing loss (SSNHL). Macrophage migration inhibitory factor (MIF) mediates its role in various immune and inflammatory conditions by the regulation of immune reactions. Several studies have confirmed an association between MIF gene polymorphisms and susceptibility to various inflammatory and autoimmune disorders. The aim of this study was to explore the association between the MIF (-173 G/C) polymorphism (rs755622) and SSNHL in an Iranian population. In this case-control association study, SSNHL cases (n = 77) were included. Normal healthy subjects (n = 100) were also recruited from the same region. Genotyping for MIF (-173 G/C) polymorphism was carried out using the polymerase chain reaction-restriction fragment length polymorphism technique. The frequency of the MIF -173 C allele carriers (GC + CC genotype) was significantly elevated in SSNHL patients who responded to glucocorticoid treatment compared with the patients with no response to treatment. These results suggest that the MIF gene polymorphism is associated with a response to glucocorticoid treatment in patients with SSNHL.

Macrophage migration inhibitory factor deficiency protects pancreatic islets from palmitic acid‐induced apoptosis

2011 ◽  
Vol 90 (7) ◽  
pp. 688-698 ◽  
Author(s):  
Tamara Saksida ◽  
Stanislava Stosic‐Grujicic ◽  
Gordana Timotijevic ◽  
Stellan Sandler ◽  
Ivana Stojanovic
Keyword(s):  
Palmitic Acid ◽  
Pancreatic Islets ◽  
Migration Inhibitory Factor ◽  
Macrophage Migration Inhibitory Factor ◽  
Inhibitory Factor ◽  
Macrophage Migration ◽  
Factor Deficiency ◽  
Induced Apoptosis
Sign in / Sign up

Export Citation Format

Share Document