Low-Resistance, Concentric-Gated Pediatric Artificial Lung for End-Stage Lung Failure

Transplantation in children has become a therapeutic option for several end stage organ diseases. The kidney, liver, and heart are the most common organs transplanted; however, an increasing number of children are undergoing successful intestine, lung, and multiple organ transplant combinations. Through case study reports, emerging transplant options for the child experiencing end stage liver, intestine, heart, and lung failure are described. Critical care nurses play a crucial role in the postoperative recovery of these patients. An understanding of the transplant process and consequences of immunosuppression will help the critical care nurse identify signs of rejection, infection, and posttransplant lymphoprolifcrative disease

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A Model of Pediatric End-Stage Lung Failure in Small Lambs <20 kg

ASAIO Journal ◽

10.1097/mat.0000000000001017 ◽

2020 ◽

Vol 66 (5) ◽

pp. 572-579

Author(s):

Benjamin D. Carr ◽

Clinton J. Poling ◽

Pavel Hala ◽

Matias Caceres Quinones ◽

Aaron R. Prater ◽

...

Keyword(s):

Lung Failure ◽

End Stage

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Use of a low-resistance compliant thoracic artificial lung in the pulmonary artery to pulmonary artery configuration

Journal of Thoracic and Cardiovascular Surgery ◽

10.1016/j.jtcvs.2013.01.020 ◽

2013 ◽

Vol 145 (6) ◽

pp. 1660-1666 ◽

Cited By ~ 8

Author(s):

Christopher N. Scipione ◽

Rebecca E. Schewe ◽

Kelly L. Koch ◽

Andrew W. Shaffer ◽

Amit Iyengar ◽

...

Keyword(s):

Pulmonary Artery ◽

Artificial Lung ◽

Low Resistance

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In-Parallel Attachment of a Low-Resistance Compliant Thoracic Artificial Lung Under Rest and Simulated Exercise

The Annals of Thoracic Surgery ◽

10.1016/j.athoracsur.2012.07.034 ◽

2012 ◽

Vol 94 (5) ◽

pp. 1688-1694 ◽

Cited By ~ 6

Author(s):

Rebecca E. Schewe ◽

Christopher N. Scipione ◽

Kelly L. Koch ◽

Keith E. Cook

Keyword(s):

Artificial Lung ◽

Low Resistance

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Impact of the artificial lung on medical care

The International Journal of Artificial Organs ◽

10.1177/039139888000300310 ◽

1980 ◽

Vol 3 (3) ◽

pp. 157-160

Author(s):

P.M. Galletti

Keyword(s):

Cardiovascular Surgery ◽

Clinical Medicine ◽

Artificial Lung ◽

The Body ◽

Heart Lung Machine ◽

Widespread Acceptance ◽

Artery Disease ◽

End Stage ◽

Lung Machine ◽

Valvular Lesions

Mechanical systems to oxygenate blood outside of the body were first employed in clinical medicine as a component of the «heart-lung machine». The artificial lung has been an essential component of the technology underlying the progress of cardiovascular surgery since 1950. Its impact on clinical medicine can be measured by the widespread acceptance of cardiac surgery for the treatment first of congenital malformations, then valvular lesions, and more recently, coronary artery disease. Whereas the use of the artificial lung during temporary exclusion of the pulmonary circulation for surgical purposes is now well established, the chronic application of extracorporeal membrane oxygenation in end-stage respiratory failure is still controversial. Internally implantable lung prostheses are still at the conceptual or developmental stage, and are unlikely to impact on clinical medicine for another decade.

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Hemodynamic effect of a low-resistance artificial lung in series with the native lungs of sheep

The Annals of Thoracic Surgery ◽

10.1016/s0003-4975(99)01470-8 ◽

2000 ◽

Vol 69 (2) ◽

pp. 351-356 ◽

Cited By ~ 27

Author(s):

William R Lynch ◽

J.Patrick Montoya ◽

David O Brant ◽

Robert J Schreiner ◽

Mark D Iannettoni ◽

...

Keyword(s):

Hemodynamic Effect ◽

Artificial Lung ◽

Low Resistance ◽

In Series

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A PROTOTYPE LOW-RESISTANCE TOTAL ARTIFICIAL LUNG IN SERIES WITH THE PULMONARY CIRCULATION

ASAIO Journal ◽

10.1097/00002480-200003000-00123 ◽

2000 ◽

Vol 46 (2) ◽

pp. 181 ◽

Cited By ~ 5

Author(s):

S. D. Lick ◽

S. K. Alpard ◽

P. Montoya ◽

D. J. Deyo ◽

S. A. Witt ◽

...

Keyword(s):

Pulmonary Circulation ◽

Artificial Lung ◽

Low Resistance ◽

In Series

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Development of a Novel, Low-Resistance Pediatric Artificial Lung for Long-Term Support

10.1542/peds.147.3_meetingabstract.931 ◽

2021 ◽

Author(s):

Brian P. Fallon ◽

Alex J. Thompson ◽

Aaron Prater ◽

Skylar Buchan ◽

Trevor Alberts ◽

...

Keyword(s):

Artificial Lung ◽

Low Resistance

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Advanced Single Cell Technologies to Guide the Development of Bioengineered Lungs

AJP Lung Cellular and Molecular Physiology ◽

10.1152/ajplung.00089.2021 ◽

2021 ◽

Author(s):

Heather Wanczyk ◽

Todd Jensen ◽

Daniel J. Weiss ◽

Christine Finck

Keyword(s):

Single Cell ◽

Membrane Integrity ◽

Proper Function ◽

Cell Populations ◽

Cell Matrix ◽

Distinct Cell ◽

Lung Failure ◽

End Stage ◽

And Function ◽

Cell Matrix Interactions

Lung transplantation remains the only viable option for individuals suffering from end-stage lung failure. However, a number of current limitations exist including a continuing shortage of suitable donor lungs and immune rejection following transplantation. To address these concerns, engineering a decellularized biocompatible lung scaffold from cadavers reseeded with autologous lung cells to promote tissue regeneration is being explored. Proof-of-concept transplantation of these bioengineered lungs into animal models has been accomplished. However, these lungs were incompletely recellularized with resulting epithelial and endothelial leakage and insufficient basement membrane integrity. Failure to repopulate lung scaffolds with all of the distinct cell populations necessary for proper function remains a significant hurdle for the progression of current engineering approaches and precludes clinical translation. Advancements in 3D bioprinting, lung organoid models and microfluidic device and bioreactor development have enhanced our knowledge of pulmonary lung development, as well as important cell-cell and cell-matrix interactions, all of which will help in the path to a bioengineered transplantable lung. However, a significant gap in knowledge of the spatiotemporal interactions between cell populations as well as relative quantities and localization within each compartment of the lung necessary for its proper growth and function remains. This review will provide an update on cells currently used for reseeding decellularized scaffolds with outcomes of recent lung engineering attempts. Focus will then be on how data obtained from advanced single cell analyses, coupled with multi-omics approaches and high-resolution 3D imaging, can guide current lung bioengineering efforts for the development of fully functional, transplantable lungs.

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