scholarly journals Heightened Expression of CD39 by Regulatory T Lymphocytes Is Associated with Therapeutic Remission in Inflammatory Bowel Disease

2015 ◽  
Vol 21 (12) ◽  
pp. 2806-2814 ◽  
Author(s):  
David J. Gibson ◽  
Louise Elliott ◽  
Edel McDermott ◽  
Miriam Tosetto ◽  
Denise Keegan ◽  
...  
Keyword(s):  
Inflammatory Bowel Disease ◽  
T Lymphocytes ◽  
Bowel Disease ◽  
Regulatory T Lymphocytes ◽  
Inflammatory Bowel

scholarly journals CD8+CD28− Regulatory T Lymphocytes Prevent Experimental Inflammatory Bowel Disease in Mice

2006 ◽  
Vol 131 (6) ◽  
pp. 1775-1785 ◽  
Author(s):  
Ingrid MÉnager–Marcq ◽  
CÉline PomiÉ ◽  
Paola Romagnoli ◽  
Joost P.M. van Meerwijk
Keyword(s):  
Inflammatory Bowel Disease ◽  
T Lymphocytes ◽  
Bowel Disease ◽  
Regulatory T Lymphocytes ◽  
Experimental Inflammatory Bowel Disease ◽  
Inflammatory Bowel

scholarly journals Pathogenesis of Inflammatory Bowel Disease: Basic Science in the Light of Real-World Epidemiology

2018 ◽  
Vol 1 (1) ◽  
pp. 129-146 ◽  
Author(s):  
Davide Ribaldone ◽  
Rinaldo Pellicano ◽  
Giovanni Actis
Keyword(s):  
Inflammatory Bowel Disease ◽  
Immune System ◽  
T Lymphocytes ◽  
Real World ◽  
Bowel Disease ◽  
Basic Science ◽  
Western World ◽  
Regulatory T Lymphocytes ◽  
Regulatory Circuits ◽  
Inflammatory Bowel

Major advances in the last few decades have favored the view of inflammatory bowel disease (IBD) as a disease of hyper- or, more often, paradoxical hyporesponsiveness of the gut-associated immune system. The relevant pivot seems to be the loss of the balance between gut-associated pro-inflammatory lymphocytes and the indwelling microbiome species, with inner regulatory circuits (regulatory T-lymphocytes, T-reg) and outer factors (such as drugs, tobacco, diet components) contributing to complicate the matter. Light might be shed by the observation of the real-world IBD epidemiology, which may help unveil the factors that tend to cluster IBD cases to certain geographical areas. A transitional mind frame between bench and real-world gastroenterology could hopefully contribute to restrain the mounting epidemic of IBD in the Western world and to halt the more recent increases seen in many Eastern countries.

scholarly journals Expression of CD45RB functionally distinguishes intestinal T lymphocytes in inflammatory bowel disease

2004 ◽  
Vol 75 (6) ◽  
pp. 1010-1015 ◽  
Author(s):  
Tessa ten Hove ◽  
F. Olle The ◽  
Marloes Berkhout ◽  
Joost P. Bruggeman ◽  
Florry A. Vyth-Dreese ◽  
...  
Keyword(s):  
Inflammatory Bowel Disease ◽  
T Lymphocytes ◽  
Bowel Disease ◽  
Inflammatory Bowel

scholarly journals Lymphocyte subpopulations and mast cells intestinal changes as indicators of inflammatory bowel disease in dogs

2019 ◽  
Author(s):  
Andrés Espinoza-Zambrano ◽  
Carlos Manuel González
Keyword(s):  
Inflammatory Bowel Disease ◽  
Mast Cells ◽  
T Lymphocytes ◽  
Lamina Propria ◽  
Bowel Disease ◽  
B Lymphocyte ◽  
Gastrointestinal Symptoms ◽  
Intestinal Barrier Function ◽  
Mucosal Permeability ◽  
Inflammatory Bowel

AbstractInflammatory bowel disease (IBD) is a disease with recurring gastrointestinal symptoms. Lymphocytes and mast cells are proposed as important components in the immunopathology of IBD in dogs. Mast cells depend on degranulation, a process that compromises mucosal permeability and normal intestinal barrier function, which alters the normal inflammatory process by allowing recruitment of lymphocytes in dogs with IBD. In this study, T and B lymphocyte populations and mast cells were examined in situ in 39 intestinal samples of dogs affected by IBD, by immunohistochemistry. Both T lymphocytes and mast cells numbers were significantly higher in the lamina propria of the intestinal wall of dogs with IBD compared with control dogs. Out of the total number of mast cells detected by CD117 expression significantly less cells appear to be granulated according to granule staining with Toluidine Blue, suggesting that an important degranulation process takes place in IBD. Single and double immune staining for tryptase and chymase showed that mast cells can express only one or both enzymes. Tryptase positive cells were significantly higher in number that chymase positive and tryptase/chymase positive cells. T lymphocytes were concentrated mostly at the upper portion of the intestinal villi lamina propria while mast cells were distributed mainly among crypts. These results suggest that populations of T lymphocytes and mast cells play a role in the immunopathology and development of IBD in dogs, also these changes could be helpful as complementary indicators of canine IBD.

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