Time to Onset of Neuropathic Pain Reduction: A Retrospective Analysis of Data From Nine Controlled Trials of Pregabalin for Painful Diabetic Peripheral Neuropathy and Postherpetic Neuralgia

2010 ◽  
Vol 17 (6) ◽  
pp. 577-585 ◽  
Author(s):  
Uma Sharma ◽  
Teresa Griesing ◽  
Birol Emir ◽  
James P Young
Keyword(s):  
Neuropathic Pain ◽  
Peripheral Neuropathy ◽  
Retrospective Analysis ◽  
Postherpetic Neuralgia ◽  
Diabetic Peripheral Neuropathy ◽  
Pain Reduction ◽  
Controlled Trials ◽  
Painful Diabetic Peripheral Neuropathy ◽  
Time To Onset

Placebo and treatment group responses in postherpetic neuralgia vs. painful diabetic peripheral neuropathy clinical trials in the REPORT database

Pain ◽  
2010 ◽  
Vol 150 (1) ◽  
pp. 12-16 ◽  
Author(s):  
Robert H. Dworkin ◽  
Dennis C. Turk ◽  
Sarah Peirce-Sandner ◽  
Michael P. McDermott ◽  
John T. Farrar ◽  
...  
Keyword(s):  
Clinical Trials ◽  
Peripheral Neuropathy ◽  
Treatment Group ◽  
Postherpetic Neuralgia ◽  
Diabetic Peripheral Neuropathy ◽  
Painful Diabetic Peripheral Neuropathy

scholarly journals Efficacy of Chinese Herbal Medicine in the Treatment of Moderate-Severe Painful Diabetic Peripheral Neuropathy: A Retrospective Study

2019 ◽  
Vol 2019 ◽  
pp. 1-10
Author(s):  
Yujiao Zheng ◽  
Fan Yang ◽  
Lin Han ◽  
Xiaowen Gou ◽  
Fengmei Lian ◽  
...  
Keyword(s):  
Neuropathic Pain ◽  
Retrospective Study ◽  
Blood Glucose ◽  
Peripheral Neuropathy ◽  
Herbal Medicine ◽  
Chinese Herbal Medicine ◽  
Diabetic Peripheral Neuropathy ◽  
Limb Pain ◽  
Chinese Herbal ◽  
Painful Diabetic Peripheral Neuropathy

Painful diabetic peripheral neuropathy (pDPN) is a debilitating complication of diabetes. The aim of this retrospective study was to investigate the effectiveness of a Chinese herbal medicine regimen—the modified Huangqi Guizhi Wuwu Decoction (HGWD)—in the treatment of moderate-severe pDPN. The primary objective was to estimate the improvement in neuropathic pain severity. The secondary objective was to assess the response of common symptoms to the treatment. The change in patients’ blood glucose level during the whole treatment was also evaluated. By searching through our medical records of all the diabetic patients from January 2006 to January 2012, we identified and enrolled 30 moderate and severe pDPN patients in the study, for whom the treatment of neuropathic pain by regular pharmacotherapies had failed. The modified HGWD treatment was administered orally twice a day for 6 months. The numerical rating scale (NRS) level at month 6 was 2.57±2.30, significantly improved compared with the baseline level of 6.03±1.83 (P<0.05). The amelioration of 3 common symptoms, namely, limb pain, limb numbness, and insomnia, was evident, and the major response of common symptoms at month 6 including limb pain, insomnia, and limb coldness was significantly increased compared with the results at month 3 (P<0.05). Moreover, 2-hour postprandial blood glucose (2hPG) level decreased from 10.77±1.29 mmol/L at baseline to 9.66±0.60 mmol/L at month 6 (P<0.05). No serious adverse events occurred throughout the treatment period. The modified HGWD was effective in the treatment of moderate and severe pDPN and can thus be offered as a new alternative treatment option for pDPN patients who failed to respond to regular pharmaceutical therapies.

Mechanical Allodynia Predicts Better Outcome of Surgical Decompression for Painful Diabetic Peripheral Neuropathy

2018 ◽  
Vol 34 (06) ◽  
pp. 446-454 ◽  
Author(s):  
Chenlong Liao ◽  
D. Nickerson ◽  
Massimiliano Visocchi ◽  
Min Yang ◽  
Pengfei Liu ◽  
...  
Keyword(s):  
Peripheral Neuropathy ◽  
Surgical Outcome ◽  
Diabetic Peripheral Neuropathy ◽  
Mechanical Allodynia ◽  
Depression Scale ◽  
Pain Reduction ◽  
Control Group ◽  
Cross Sectional ◽  
Painful Diabetic Peripheral Neuropathy ◽  
High Resolution Ultrasonography

Background To determine the role of mechanical allodynia (MA) in predicting good surgical outcome for painful diabetic peripheral neuropathy (DPN). Materials and Methods Data of 192 patients with painful DPN were collected in this study, with 148 surgical patients and 44 patients in the control group. Both groups were further divided into subgroups based on the presence of MA on admission. Clinical evaluations including the visual analog scale (VAS), the Hospital Anxiety and Depression Scale (HADS), nerve conduction velocity (NCV), and high-resolution ultrasonography (cross-sectional area, CSA) were performed preoperatively and postoperatively. Results The levels of VAS and HADS and the results of NCV and CSA were improved in the surgical group (p < 0.05). In the surgical subgroups, pain reduction, psychiatric amelioration, improvement in NCVs, and the restoration of the CSA were observed in patients with signs of MA (p < 0.05), whereas only pain reduction, psychiatric amelioration, and restoration of the CSA were noted in patients without signs of MA (p > 0.05). Furthermore, better pain reduction was achieved in patients with MA when compared with those without MA (p < 0.05). Conclusions MA is proved to be a reliable predictor of good surgical outcome for painful DPN.

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