Pancreas preservation

2020 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Julien Branchereau ◽  
James Hunter ◽  
Peter Friend ◽  
Rutger Ploeg
2019 ◽  
Vol 5 (1) ◽  
Author(s):  
Kenji Kandori ◽  
Wataru Ishii ◽  
Ryoji Iizuka

Abstract Background The guidelines recommend pancreatic resection for grade III and IV pancreatic injuries. On the other hand, organ preservation is an important issue. Herein, we present the first case of pancreatic injury with major pancreatic duct (MPD) disruption that was treated with the combination of preoperative placement of endoscopic nasopancreatic drainage (ENPD) catheter and pancreas preservation surgery after endoscopic pancreatic stenting (EPS) failure. Case presentation A 70-year-old female diagnosed with pancreatic injury was admitted to our hospital. She was hemodynamically stable. ERP revealed MPD disruption, and EPS failed. An ENPD catheter was placed preoperatively at the site of injury. During laparotomy, we identified a partial-thickness laceration in the pancreatic body. At the site of injury, the tip of the ENPD catheter was found; therefore, the patient was diagnosed with grade III pancreatic body injury with MPD disruption. The extent of crush was not severe, and we had no difficulty in identifying the distal MPD segment. We inserted the ENPD catheter into the distal MPD segment. The ruptured MPD and the laceration was sutured, then pancreatic resection was prevented. She was discharged on POD 56. Conclusion The treatment strategy incorporated ERP, placement of an ENPD catheter preoperatively, and a simple surgery in a hemodynamically stable patient with pancreatic injury allows the pancreas and spleen to be preserved.


2021 ◽  
Vol 22 (10) ◽  
pp. 5172
Author(s):  
Thomas Prudhomme ◽  
John F. Mulvey ◽  
Liam A. J. Young ◽  
Benoit Mesnard ◽  
Maria Letizia Lo Faro ◽  
...  

Maintaining organ viability between donation and transplantation is of critical importance for optimal graft function and survival. To date in pancreas transplantation, static cold storage (SCS) is the most widely practiced method of organ preservation. The first experiments in ex vivo perfusion of the pancreas were performed at the beginning of the 20th century. These perfusions led to organ oedema, hemorrhage, and venous congestion after revascularization. Despite these early hurdles, a number of factors now favor the use of perfusion during preservation: the encouraging results of HMP in kidney transplantation, the development of new perfusion solutions, and the development of organ perfusion machines for the lung, heart, kidneys and liver. This has led to a resurgence of research in machine perfusion for whole organ pancreas preservation. This review highlights the ischemia-reperfusion injuries assessment during ex vivo pancreas perfusion, both for assessment in pre-clinical experimental models as well for future use in the clinic. We evaluated perfusion dynamics, oedema assessment, especially by impedance analysis and MRI, whole organ oxygen consumption, tissue oxygen tension, metabolite concentrations in tissue and perfusate, mitochondrial respiration, cell death, especially by histology, total cell free DNA, caspase activation, and exocrine and endocrine assessment.


2008 ◽  
Vol 13 (2) ◽  
pp. 135-141 ◽  
Author(s):  
Yasuhiro Iwanaga ◽  
David ER Sutherland ◽  
James V Harmon ◽  
Klearchos K Papas

2006 ◽  
Vol 81 (3) ◽  
pp. 492-493 ◽  
Author(s):  
Daniel Brandhorst ◽  
Reinhard G. Bretzel ◽  
Heide Brandhorst

Surgery ◽  
1997 ◽  
Vol 122 (2) ◽  
pp. 435-442 ◽  
Author(s):  
Yasuki Tanioka ◽  
David E.R Sutherland ◽  
Yoshikazu Kuroda ◽  
Thomas R Gilmore ◽  
Tor C Asaheim ◽  
...  

2004 ◽  
Vol 78 ◽  
pp. 352
Author(s):  
T Tsujimura ◽  
Y Kuroda ◽  
J Avila ◽  
T Kin ◽  
A M.J. Shapiro ◽  
...  

Suizo ◽  
2011 ◽  
Vol 26 (2) ◽  
pp. 142-152
Author(s):  
Ippei MATSUMOTO ◽  
Makoto SHINZEKI ◽  
Hirochika TOYAMA ◽  
Sadaki ASARI ◽  
Tadahiro GOTO ◽  
...  

2004 ◽  
Vol 77 (8) ◽  
pp. 1186-1190 ◽  
Author(s):  
Ugo Boggi ◽  
Fabio Vistoli ◽  
Marco Del Chiaro ◽  
Stefano Signori ◽  
Chiara Croce ◽  
...  

1997 ◽  
Vol 29 (8) ◽  
pp. 3522-3523 ◽  
Author(s):  
U.J. Hesse ◽  
R. Troisi ◽  
B. Jacobs ◽  
F. Berrevoet ◽  
S. De Laere ◽  
...  

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