Third Trimester Fetal Intracranial Hemorrhage Owing to Vitamin K Deficiency Associated With Hyperemesis Gravidarum

Vitamin K deficiency bleeding (VKDB) can manifest as intracranial hemorrhage (ICH) and is still prevalent in poor resource countries. Infants aged one to twelve months with the diagnosis of ICH from 1st July 2011 to 30th June 2016 were included. There were 16 cases of ICH attributed to vitamin K deficiency. Clinical presentations were anemia16 (100%), bulged fontanel 13(81.3%), seizures 10(62.5%), vomiting 8(50%) and fever 9(56.3%). Mean INR at admission was 8.575±7.267 and 1.868±0.838 after three doses of vitamin K administration. Sites of intracranial bleed were parenchymal 5(31.3%), subdural 4(25%), extradural 2(12.5%), ventricular 2(12.5%). In 3(18.8%) of cases bleeding was more extensive involving more than one site. Mortality was 4(25%) and 3(18.8%) had abnormal neurological findings at discharge. There is an urgent need for national policy for vitamin K prophylaxis at birth.

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Intraperitoneal Hemorrhage in a Pregnant Woman with Hyperemesis Gravidarum: Vitamin K Deficiency as a Possible Cause

Case Reports in Obstetrics and Gynecology ◽

10.1155/2016/5384943 ◽

2016 ◽

Vol 2016 ◽

pp. 1-3 ◽

Cited By ~ 3

Author(s):

Yosuke Baba ◽

Hiroyuki Morisawa ◽

Koyomi Saito ◽

Hironori Takahashi ◽

Kazuma Rifu ◽

...

Keyword(s):

Abdominal Pain ◽

Intestinal Obstruction ◽

Vitamin K ◽

Pain Treatment ◽

Hyperemesis Gravidarum ◽

Japanese Woman ◽

Hemorrhagic Diathesis ◽

Vitamin K Deficiency ◽

Vitamin Deficiencies ◽

K Deficiency

Hyperemesis gravidarum can cause various vitamin deficiencies. Vitamin K deficiency can lead to coagulopathy or hemorrhagic diathesis. A nulliparous Japanese woman with hyperemesis gravidarum at 105/7weeks was admitted with giant myoma, intestinal obstruction, and abdominal pain. Treatment for a degenerative myoma was instituted with intravenous antibiotics. The abdominal pain ameliorated, but intestinal obstruction persisted. At 166/7weeks, we performed laparotomy for release of intestinal obstruction, when intraabdominal bleeding of 110 mL existed. Blood tests revealed coagulopathy secondary to vitamin K deficiency. The coagulopathy responded to intravenous vitamin K injection. Coagulopathy due to vitamin K deficiency can occur with hyperemesis gravidarum, and coexisting intestinal obstruction and broad-spectrum antibiotics can aggravate the deficiency.

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Gray matter heterotopias and brachytelephalangic chondrodysplasia punctata: A complication of hyperemesis gravidarum induced vitamin K deficiency?

American Journal of Medical Genetics Part A ◽

10.1002/ajmg.a.31573 ◽

2007 ◽

Vol 143A (2) ◽

pp. 200-204 ◽

Cited By ~ 19

Author(s):

Nicola Brunetti-Pierri ◽

Jill V. Hunter ◽

Cornelius F. Boerkoel

Keyword(s):

Vitamin K ◽

Gray Matter ◽

Hyperemesis Gravidarum ◽

Chondrodysplasia Punctata ◽

Vitamin K Deficiency ◽

K Deficiency

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Intracranial Hemorrhage in Early Infancy—Renewed Importance of Vitamin K Deficiency

Pediatric Neurology ◽

10.1016/j.pediatrneurol.2014.02.017 ◽

2014 ◽

Vol 50 (6) ◽

pp. 545-546 ◽

Cited By ~ 12

Author(s):

Joseph J. Volpe

Keyword(s):

Intracranial Hemorrhage ◽

Vitamin K ◽

Early Infancy ◽

Vitamin K Deficiency ◽

K Deficiency

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X-Linked Chronic Granulomatous Disease: Initial Presentation with Intracranial Hemorrhage from Vitamin K Deficiency in Infant

Case Reports in Pediatrics ◽

10.1155/2018/7041204 ◽

2018 ◽

Vol 2018 ◽

pp. 1-6

Author(s):

Boonchai Boonyawat ◽

Yiwa Suksawat ◽

Punchama Pacharn ◽

Piradee Suwanpakdee ◽

Chanchai Traivaree

Keyword(s):

Intracranial Hemorrhage ◽

Vitamin K ◽

Neonatal Period ◽

Granulomatous Disease ◽

Mycobacterial Disease ◽

Vitamin K Deficiency ◽

Vitamin K Deficiency Bleeding ◽

Threatening Condition ◽

Life Threatening ◽

K Deficiency

Vitamin K deficiency bleeding (VKDB) is a life-threatening condition and can be found in children as early as neonatal period with early onset intracranial hemorrhage (ICH). Here, we reported a 1-year-old boy who initially presented with intracranial hemorrhage secondary to vitamin K deficiency since 3 months of age and later found to have XL-CGD which was complicated by malabsorption due to severe vaccine-associated mycobacterial disease.

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