Randomized Clinical Trial of 20% Mannitol Versus 3% Hypertonic Saline in Children With Raised Intracranial Pressure Due to Acute CNS Infections*

2020 ◽  
Vol 21 (12) ◽  
pp. 1071-1080 ◽  
Author(s):  
Ramachandran Rameshkumar ◽  
Arun Bansal ◽  
Sunit Singhi ◽  
Pratibha Singhi ◽  
Muralidharan Jayashree
Keyword(s):  
Clinical Trial ◽  
Intracranial Pressure ◽  
Randomized Clinical Trial ◽  
Hypertonic Saline ◽  
Raised Intracranial Pressure ◽  
Cns Infections

scholarly journals Individualizing hyperosmolar therapy for management of intracranial hypertension

2018 ◽  
Vol 4 (2) ◽  
pp. 54-56
Author(s):  
Gentle Sunder Shrestha
Keyword(s):  
Intracranial Pressure ◽  
Intracranial Hypertension ◽  
Hypertonic Saline ◽  
Significant Heterogeneity ◽  
Raised Intracranial Pressure ◽  
Threshold Method ◽  
Treatment Threshold ◽  
Hyperosmolar Therapy ◽  
Surgical Options ◽  
Selection Of

Intracranial hypertension is a major cause of morbidity and mortality in patients with brain injury. If not appropriately treated, it can precipitate brain ischemia, brain herniation and death. Hyperosmolar therapy remains the main armamentarium for management of raised intracranial pressure, especially in patients with diffuse lesions and where surgical options are not applicable. Substantial amount of studies have tried to explore the superiority of hypertonic saline or mannitol over the other. Due to significant heterogeneity in the pathophysiology of patients, variation in treatment threshold, method of drug administration and drug concentration, substantial evidence is lacking to support one agent over other. Hypertonic saline may be more effective than mannitol for lowering raised intracranial pressure. Well designed novel trials need to try to find the answer. Clinical, pathophysiological and biochemical data should be incorporated at bedside while individualizing selection of hyperosmolar therapy, with the aim to improve outcome and minimize harm.Journal of Society of Anesthesiologists of NepalVol. 4, No. 2, 2017, Page: 54-56 

A randomized clinical trial of the addition of laminaria to misoprostol and hypertonic saline for second-trimester induction abortion

Contraception ◽  
2005 ◽  
Vol 72 (5) ◽  
pp. 358-361 ◽  
Author(s):  
Lynn Borgatta ◽  
Angela Y. Chen ◽  
Olivera Vragovic ◽  
Phillip G. Stubblefield ◽  
Christ-Ann Magloire
Keyword(s):  
Clinical Trial ◽  
Randomized Clinical Trial ◽  
Hypertonic Saline ◽  
Second Trimester

Cerebral Hemodynamic Effects of 7.2% Hypertonic Saline in Patients with Head Injury and Raised Intracranial Pressure

2000 ◽  
Vol 17 (1) ◽  
pp. 41-51 ◽  
Author(s):  
FRANCISCA MUNAR ◽  
ANA M. FERRER ◽  
MIRIAM de NADAL ◽  
MARÍA A. POCA ◽  
SALVADOR PEDRAZA ◽  
...  
Keyword(s):  
Head Injury ◽  
Intracranial Pressure ◽  
Hypertonic Saline ◽  
Raised Intracranial Pressure ◽  
Hemodynamic Effects ◽  
Cerebral Hemodynamic
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