Universal HIV testing of infants at immunization clinics: an acceptable and feasible approach for early infant diagnosis in high HIV prevalence settings

AIDS ◽  
2009 ◽  
Vol 23 (14) ◽  
pp. 1851-1857 ◽  
Author(s):  
Nigel Rollins ◽  
Similo Mzolo ◽  
Tammy Moodley ◽  
Tonya Esterhuizen ◽  
Heidi van Rooyen
Keyword(s):  
Hiv Testing ◽  
Hiv Prevalence ◽  
Early Infant Diagnosis ◽  
Early Infant

scholarly journals Associations of Sociodemographic and Clinical Factors with Late Presentation for Early Infant HIV Diagnosis (EID) Services in Kenya

2021 ◽  
Vol 10 (2) ◽  
pp. 210-220
Author(s):  
Agnes Langat ◽  
Tegan Callahan ◽  
Isabella Yonga ◽  
Boniface Ochanda ◽  
Anthony Waruru ◽  
...  
Keyword(s):  
Global Health ◽  
Hiv Testing ◽  
Late Presentation ◽  
Health Facilities ◽  
Inpatient Setting ◽  
Sociodemographic Characteristics ◽  
Early Infant Diagnosis ◽  
Hiv Diagnosis ◽  
Positive Polymerase Chain Reaction ◽  
Early Infant

Background: Understanding the missed opportunities in early infant HIV testing within the PMTCT program is essential to address any gaps. The study set out to describe the clinical and sociodemographic characteristics of the infants presenting late for early infant diagnosis in Kenya. Methods: We abstracted routinely collected clinical and sociodemographic characteristics, in a cross-sectional study, on all HIV-infected infants with a positive polymerase chain reaction (PCR) test from 1,346 President’s Emergency Plan for AIDS Relief (PEPFAR) supported health facilities for the period October 2016 to September 2018. We used multivariate logistic regression to examine the association of sociodemographic and clinical characteristics with late (>2 months after birth) presentation for infant HIV testing. Results: Of the 4,011 HIV-infected infants identified, the median infant age at HIV diagnosis was 3 months [interquartile range (IQR), 1-16 months], and two-thirds [2,669 (66.5%)] presented late for infant HIV testing. Factors that were associated with late presentation for infant testing were: maternal ANC non-attendance, adjusted odds ratio (aOR) 1.41 (95% confidence interval (CI) 1.18 -1.69); new maternal HIV diagnosis, aOR 1.45, (95%CI 1.24 -1.7); and lack of maternal antiretroviral therapy(ART), aOR 1.94, (95% CI 1.64 - 2.30). There was a high likelihood of identifying HIV-infected infants among infants who presented for medical services in the outpatient setting (aOR 18.9; 95% CI 10.2 - 34.9) and inpatient setting (aOR 12.2; 95% CI 6.23-23.9) compared to the infants who presented late in maternity. Conclusion and Global Health Implications: Gaps in early infant HIV testing suggest the need to increase maternal pre-pregnancy HIV diagnosis, timely antenatal care, early infant diagnosis services, early identification of mothers who seroconvert during pregnancy or breastfeeding and improved HIV screening in outpatient and inpatient settings. Early referral from the community and access to health facilities should be strengthened by the implementation of national PMTCT guidelines.   Copyright © 2021 Langat et al. Published by Global Health and Education Projects, Inc. This is an open-access article distributed under the terms of the Creative Commons Attribution License CC BY 4.0.

Consolidating HIV testing in a public health laboratory for efficient and sustainable early infant diagnosis (EID) in Uganda

2015 ◽  
Vol 36 (2) ◽  
pp. 153-169 ◽  
Author(s):  
Charles Kiyaga ◽  
Hakim Sendagire ◽  
Eleanor Joseph ◽  
Jeff Grosz ◽  
Ian McConnell ◽  
...  
Keyword(s):  
Public Health ◽  
Hiv Testing ◽  
Public Health Laboratory ◽  
Early Infant Diagnosis ◽  
Early Infant

Results of Baseline Assessments of Two Viral Load and Early Infant Diagnosis Laboratories in Gaza Province, Mozambique

2019 ◽  
Vol 152 (Supplement_1) ◽  
pp. S79-S79
Author(s):  
Augusto Nhabomba ◽  
Mariamo Assane ◽  
Noorbebi Adamo ◽  
Octavia Benzane ◽  
Isabel Pinto ◽  
...  
Keyword(s):  
Viral Load ◽  
Scale Up ◽  
Hiv Prevalence ◽  
Internal Quality ◽  
Early Infant Diagnosis ◽  
Hiv Viral Load ◽  
Early Infant ◽  
Sample Management ◽  
Basic Infrastructure

Abstract Following the WHO 2013 recommendations for routine HIV viral load (VL) testing as the tool to monitor antiretroviral therapy, countries have prepared for massive testing scale-up. However, developing countries that also bear the highest HIV prevalence often lack qualified human resources and basic infrastructure. Mozambique has established 13 VL laboratories, including 2 in the province with the highest overall HIV prevalence, Gaza. The challenges to VL testing implementation and this rapid scale-up demand an urgent investment toward laboratory accreditation to ensure accurate and reliable VL results. To identify gaps and areas for improvement where additional resources may be needed to provide high-quality VL testing services, the CDC developed a VL and Early Infant Diagnosis (EID) scorecard (106 points; 5 levels). The scorecard evaluates 9 key areas, including (1) Personnel, (2) Facility/Environment, (3) Safety, (4) Procurement/Inventory, (5) Sample Management, (6) Equipment, (7) Process Control, (8) M&E Documents and Records, and (9) Internal Quality Audits/Quality Indicators. These 9 essential areas cover the pretesting, testing, and posttesting phases along the continuum of care for HIV patients. Baseline assessments in the two VL and EID laboratories in Gaza Province, Carmelo Molecular Laboratory and Xai-Xai Molecular Laboratory, were recently conducted. Personnel standards and M&E documentation represented strengths across both laboratories, with over 70% of the master list of M&E documents having been developed and in use. The overall gaps identified included poor segregation and prioritization of higher VL results (>1,000 cp/mL), lack of internal audits, and no follow-up of nonconformities. Both laboratories scored in the level 2 range, with a total of 68 points (Carmelo) and 78 points (Xai-Xai). Considering this is a baseline assessment, we conclude that both labs are on an excellent path toward accreditation; however, additional laboratory quality mentorship is needed in order to reach accreditation standards.

scholarly journals Point-of-care HIV testing best practice for early infant diagnosis: an implementation study

2019 ◽  
Vol 19 (1) ◽  
Author(s):  
Elizabeth Spooner ◽  
Kerusha Govender ◽  
Tarylee Reddy ◽  
Gita Ramjee ◽  
Noxolo Mbadi ◽  
...  
Keyword(s):  
Hiv Testing ◽  
Best Practice ◽  
Point Of Care ◽  
Implementation Study ◽  
Early Infant Diagnosis ◽  
Early Infant

scholarly journals The NSEBA Demonstration Project: Implementation of a point‐of‐care platform for early infant diagnosis of HIV in rural Zambia

2021 ◽  
Author(s):  
Catherine G. Sutcliffe ◽  
Nkumbula Moyo ◽  
Jessica L. Schue ◽  
Jane N. Mutanga ◽  
Mutinta Hamahuwa ◽  
...  
Keyword(s):  
Point Of Care ◽  
Demonstration Project ◽  
Early Infant Diagnosis ◽  
Project Implementation ◽  
Early Infant ◽  
Rural Zambia

Early infant diagnosis of HIV infection in low-income and middle-income countries: does one size fit all?

2014 ◽  
Vol 14 (7) ◽  
pp. 650-655 ◽  
Author(s):  
Martina Penazzato ◽  
Paul Revill ◽  
Andrew J Prendergast ◽  
Intira J Collins ◽  
Simon Walker ◽  
...  
Keyword(s):  
Hiv Infection ◽  
Low Income ◽  
Early Infant Diagnosis ◽  
Middle Income ◽  
Middle Income Countries ◽  
Early Infant
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