Molecular Epidemiology of HIV-1 Subtype B, CRF01_AE, and CRF07_BC Infection Among Injection Drug Users in Taiwan

2010 ◽  
Vol 53 (4) ◽  
pp. 425-439 ◽  
Author(s):  
Yen-Ju Chen ◽  
Yu-Huei Huang ◽  
Shao-Yuan Chuang ◽  
Diana Yu-Ting Kao ◽  
Yu-Ching Lan ◽  
...  
Keyword(s):  
Molecular Epidemiology ◽  
Injection Drug Users ◽  
Drug Users ◽  
Injection Drug ◽  
Subtype B ◽  
Hiv 1

Prevalence of Different Genotypes of HIV-1 in Injection Drug Users in China: A Systematic Review and Meta-Analysis

2019 ◽  
Vol 17 (4) ◽  
pp. 240-257
Author(s):  
Yu Jiang ◽  
Lincai Zhang ◽  
Zongjie Hou ◽  
Aixia Tu ◽  
Ruijuan Qiao ◽  
...  
Keyword(s):  
Systematic Review ◽  
Injection Drug Users ◽  
Drug Users ◽  
Meta Analysis ◽  
Sexual Transmission ◽  
Injection Drug ◽  
Subtype C ◽  
Subtype B ◽  
Prevalent Strain ◽  
Hiv 1

Background: Since 1981, an increasing trend in HIV has been observed for transmission via injection drug users (IDUs), sexual transmission and mother-to-child transmission. The IDUs are blamed for early increases in HIV-positive cases in China. Objective: HIV genotypes of IDUs were comprehensively analysed to trace the source and relationships of the AIDS epidemic in China. Methods: Relevant databases written in English and Chinese were searched. Overall, 7,149 publications were identified in six databases. After screening 7,104 articles according to the inclusion and exclusion criteria, 45 studies consisting of 2,765 cases were finally identified. A meta-analysis was conducted using R MATLAB software, RevMan and SPSS. Subgroup analyses focused on time frame, region, and location of different genotypes of IDUs in China. Results: There were five dominant HIV-1 genotypes among the 2,765 IDU cases. The proportions of CRF07_BC, CRF01_AE, CRF08_BC, subtype B/B', and subtype C were 45.18% (95% CI: 33.55-57.08%), 16.00% (95% CI: 9.39-23.82%), 13.43% (95% CI: 7.32-20.84%), 3.58% (95% CI: 1.52-6.24%), and 0.90% (95% CI: 0.04-2.43%), respectively. HIV genotypes transmitted among IDUs in China are primarily CRF07-BC, followed by CRF01-AE and CRF08-BC. Across the different time frames and regions, CRF07_BC was the most prevalent HIV-1 genotype among IDUs, while CRF08_BC was the most prevalent genotype in the southwest region. Conclusion: Our study reveals that CRF07-BC was the dominant prevalent strain among IDUs from 1991 to 2015 in China, while CRF08-BC was the dominant prevalent strain among IDUs in southwestern China. This systematic review and meta-analysis shows evidence of the comprehensive prevalence of different genotypes, data and characteristics of HIV among IDUs in China.

scholarly journals Molecular epidemiology of HIV-1 in Iceland: Early introductions, transmission dynamics and recent outbreaks among injection drug users

2017 ◽  
Vol 49 ◽  
pp. 157-163 ◽  
Author(s):  
Malik Sallam ◽  
Joakim Esbjörnsson ◽  
Guðrún Baldvinsdóttir ◽  
Hlynur Indriðason ◽  
Thora Björg Björnsdóttir ◽  
...  
Keyword(s):  
Molecular Epidemiology ◽  
Injection Drug Users ◽  
Drug Users ◽  
Injection Drug ◽  
Transmission Dynamics ◽  
Hiv 1

scholarly journals Molecular Epidemiology of HIV‐1 Infection and Full‐Length Genomic Analysis of Circulating Recombinant Form 07_BC Strains from Injection Drug Users in Taiwan

2007 ◽  
Vol 195 (9) ◽  
pp. 1283-1293 ◽  
Author(s):  
Yu‐Ting Lin ◽  
Yu‐Ching Lan ◽  
Yen‐Ju Chen ◽  
Yu‐Hui Huang ◽  
Cheng‐Ming Lee ◽  
...  
Keyword(s):  
Molecular Epidemiology ◽  
Injection Drug Users ◽  
Drug Users ◽  
Genomic Analysis ◽  
Full Length ◽  
Injection Drug ◽  
Recombinant Form ◽  
Hiv 1

The Effect of RANTES Chemokine Genetic Variants on Early HIV-1 Plasma RNA Among African American Injection Drug Users

2005 ◽  
Vol 38 (5) ◽  
pp. 584-589 ◽  
Author(s):  
Priya Duggal ◽  
Cheryl A Winkler ◽  
Ping An ◽  
Xiao-Fang Yu ◽  
Homayoon Farzadegan ◽  
...  
Keyword(s):  
African American ◽  
Genetic Variants ◽  
Injection Drug Users ◽  
Drug Users ◽  
Injection Drug ◽  
Plasma Rna ◽  
Hiv 1

Relationship between HIV-1 viral load and continued drug use in untreated infected injection drug users

1999 ◽  
Vol 4 (2) ◽  
pp. 197-202 ◽  
Author(s):  
MARIA PATRIZIA CARRIERI ◽  
CATHERINE TAMALET ◽  
DAVID VLAHOV ◽  
NOUARA YAHI ◽  
MARGARET CHESNEY ◽  
...  
Keyword(s):  
Viral Load ◽  
Drug Use ◽  
Injection Drug Users ◽  
Drug Users ◽  
Injection Drug ◽  
Hiv 1

HIV-1 incidence estimates using IgG-capture BED-enzyme immunoassay from surveillance sites of injection drug users in three cities of China

AIDS ◽  
2007 ◽  
Vol 21 (Suppl 8) ◽  
pp. S47-S51 ◽  
Author(s):  
Yan Jiang ◽  
Minjie Wang ◽  
Mingjian Ni ◽  
Song Duan ◽  
Yulin Wang ◽  
...  
Keyword(s):  
Enzyme Immunoassay ◽  
Injection Drug Users ◽  
Drug Users ◽  
Injection Drug ◽  
Hiv 1

scholarly journals Molecular Epidemiology of Hepatitis C Virus in a Social Network of Injection Drug Users

2004 ◽  
Vol 190 (9) ◽  
pp. 1586-1595 ◽  
Author(s):  
Campbell K. Aitken ◽  
Rhonda F. McCaw ◽  
D. Scott Bowden ◽  
Samantha L. Tracy ◽  
Jenny G. Kelsall ◽  
...  
Keyword(s):  
Social Network ◽  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Molecular Epidemiology ◽  
Injection Drug Users ◽  
Drug Users ◽  
Injection Drug

scholarly journals Patterns of heroin and cocaine injection and plasma HIV-1 RNA suppression among a long-term cohort of injection drug users

2012 ◽  
Vol 124 (1-2) ◽  
pp. 108-112 ◽  
Author(s):  
Thomas Kerr ◽  
Brandon D.L. Marshall ◽  
M.-J. Milloy ◽  
Ruth Zhang ◽  
Silvia Guillemi ◽  
...  
Keyword(s):  
Injection Drug Users ◽  
Drug Users ◽  
Injection Drug ◽  
Hiv 1

scholarly journals Intersubtype Human Immunodeficiency Virus Type 1 Superinfection following Seroconversion to Primary Infection in Two Injection Drug Users

2002 ◽  
Vol 76 (15) ◽  
pp. 7444-7452 ◽  
Author(s):  
Artur Ramos ◽  
Dale J. Hu ◽  
Lily Nguyen ◽  
Kim-Oanh Phan ◽  
Suphak Vanichseni ◽  
...  
Keyword(s):  
Human Immunodeficiency Virus ◽  
Human Immunodeficiency Virus Type ◽  
Virus Type ◽  
Injection Drug Users ◽  
Primary Infection ◽  
Drug Users ◽  
Injection Drug ◽  
Immunodeficiency Virus ◽  
Hiv 1

ABSTRACT In this study, we describe two cases of human immunodeficiency virus type 1 (HIV-1) intersubtype superinfection with CRF01_AE and subtype B strains, which occurred in two injection drug users participating in a prospective cohort study in Bangkok, Thailand. In both cases, the superinfecting strain was detected by molecular and serologic analyses several weeks after complete seroconversion to the primary infection with a strain belonging to a different subtype. Superinfection occurred despite specific T-cell and humoral antibody responses to the primary virus. In both cases, cross-subtype immune responses were limited or absent prior to the second infection. These data show that, in some individuals, the quality and quantity of the immune response elicited by primary HIV-1 infection may not protect against superinfection. This finding has important implications for vaccine design. HIV-1 vaccines, at a minimum, will need to include potent, broadly protective, conserved immunogens derived from several group M subtypes.

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