Abstract
18F-FDG and 68Ga-citrate PET/CT have both been shown to be
useful in the management of tuberculosis (TB). We compared the abnormal PET
findings of 18F-FDG- and 68Ga-citrate-PET/CT in patients
with TB.
Methods Patients with TB on anti-TB therapy were included. Patients had a
set of PET scans consisting of both 18F-FDG and
68Ga-citrate. Abnormal lesions were identified, and the two sets of
scans were compared. The scan findings were correlated to the clinical data as
provided by the attending physician.
Results 46 PET/CT scans were performed in 18 patients, 11 (61 %) were
female, and the mean age was 35.7 ± 13.5 years. Five patients also had both
studies for follow-up reasons during the use of anti-TB therapy. Thirteen
patients were co-infected with HIV. 18F-FDG detected more lesions
than 68Ga-citrate (261 vs. 166, p < 0.0001).
68Ga-citrate showed a better definition of intracerebral lesions due
to the absence of tracer uptake in the brain. The mean SUVmax was higher for
18F-FDG compared to 68Ga-citrate (5.73 vs. 3.01,
p < 0.0001). We found a significant correlation between the SUVmax of lesions
that were determined by both tracers (r = 0.4968, p < 0.0001).
Conclusion Preliminary data shows 18F-FDG-PET detects more
abnormal lesions in TB compared to 68Ga-citrate. However,
68Ga-citrate has better lesion definition in the brain and is
therefore especially useful when intracranial TB is suspected.
Bone Marrow Stromal Cell Transplantation Enhances Recovery of Local Glucose Metabolism After Cerebral Infarction in Rats: A Serial 18F-FDG PET Study