scholarly journals Early Prediction of Histopathological Tumor Response to Preoperative Chemotherapy by Tc-99m MIBI Imaging in Bone and Soft Tissue Sarcomas

2010 ◽  
Vol 35 (3) ◽  
pp. 154-159 ◽  
Author(s):  
Junichi Taki ◽  
Anri Inaki ◽  
Hiroshi Wakabayashi ◽  
Hisashi Sumiya ◽  
Hiroyuki Tsuchiya ◽  
...  
Keyword(s):  
Soft Tissue ◽  
Preoperative Chemotherapy ◽  
Tumor Response ◽  
Soft Tissue Sarcomas ◽  
Early Prediction

scholarly journals Choi Vs. Recist Assessment of Tumor Response in a Retrospective Analysis of Patients (Pts) Receiving Trabectedin (T) for Advanced Soft Tissue Sarcomas (Asts)

2014 ◽  
Vol 25 ◽  
pp. iv504
Author(s):  
S. Taieb ◽  
E. Saada ◽  
E. Tresch ◽  
T. Ryckewaert ◽  
E. Bompas ◽  
...  
Keyword(s):  
Soft Tissue ◽  
Retrospective Analysis ◽  
Tumor Response ◽  
Soft Tissue Sarcomas

scholarly journals Prediction of final tumor response to preoperative chemotherapy by Tc-99m MIBI imaging at the middle of chemotherapy in malignant bone and soft tissue tumors: Comparison with Tl-201 imaging

2008 ◽  
Vol 26 (3) ◽  
pp. 411-418 ◽  
Author(s):  
Junichi Taki ◽  
Takahiro Higuchi ◽  
Hisashi Sumiya ◽  
Hiroyuki Tsuchiya ◽  
Hiroshi Minato ◽  
...  
Keyword(s):  
Soft Tissue ◽  
Preoperative Chemotherapy ◽  
Tumor Response ◽  
Soft Tissue Tumors

scholarly journals Preoperative Chemotherapy for Soft-tissue Sarcomas of the Extremities

1990 ◽  
Vol 211 (4) ◽  
pp. 476-481 ◽  
Author(s):  
CHRISTOPHER M. PEZZI ◽  
RAPHAEL E. POLLOCK ◽  
HARRY L. EVANS ◽  
JAMES G. LORIGAN ◽  
THOMAS A. PEZZI ◽  
...  
Keyword(s):  
Soft Tissue ◽  
Preoperative Chemotherapy ◽  
Soft Tissue Sarcomas

Feasibility of Preoperative Chemotherapy With or Without Radiation Therapy in Localized Soft Tissue Sarcomas of Limbs and Superficial Trunk in the Italian Sarcoma Group/Grupo Español de Investigación en Sarcomas Randomized Clinical Trial: Three Versus Five Cycles of Full-Dose Epirubicin Plus Ifosfamide

2015 ◽  
Vol 33 (31) ◽  
pp. 3628-3634 ◽  
Author(s):  
Elena Palassini ◽  
Stefano Ferrari ◽  
Paolo Verderio ◽  
Antonino De Paoli ◽  
Javier Martin Broto ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Radiation Therapy ◽  
Soft Tissue ◽  
Randomized Clinical Trial ◽  
Preoperative Chemotherapy ◽  
Soft Tissue Sarcomas ◽  
Phase Iii ◽  
Wound Complications ◽  
Hematologic Toxicity ◽  
Grade 3

Purpose We report on feasibility of preoperative chemotherapy with or without radiation therapy (RT) in the context of a phase III randomized clinical trial involving localized, high-risk, soft tissue sarcomas. Patients and Methods Of 321 eligible patients, 161 were randomly assigned to three preoperative cycles of epirubicin 120 mg/m2 plus ifosfamide 9 g/m2, and 160 were randomly assigned to three preoperative plus two postoperative cycles. Among them, 303 patients were included in this analysis; 169 were male and 134 were female, with a median age of 48 years (range, 15 to 79 years). One hundred fifty-two patients received concurrent RT preoperatively at a total dose of 44 to 50 Gy. Preoperative chemotherapy-related hematologic toxicity and early postoperative complications were reported. The influence of RT, age, and sex on hematologic grade 3 or 4 toxicities and wound complications was analyzed. Chemotherapeutic dose intensity (DI) was analyzed. Results Among the patients, 61.4%, 22.4%, and 23.8% experienced, grade 4 leucopenia, grade 3 or 4 anemia, and grade 3 or 4 thrombocytopenia, respectively. Respective rates were 66.4%, 24.3%, and 31.6% when RT was added preoperatively, and 56.3%, 20.5%, and 15.9% when preoperative chemotherapy was administered alone. Patient age affected grade 3 or 4 thrombocytopenia. Grade 4 leucopenia and grade 3 or 4 anemia presented 2.5 times more frequently in female patients than in male patients. Wound complications were observed in 13.5% of patients: 17% with preoperative RT and 10% without. Chemotherapeutic DI was greater than 90%, even in patients receiving preoperative RT and in patients age 65 years or older. Conclusion This preoperative chemotherapy is feasible and can also be proposed for selected elderly patients. Grade 3 or 4 hematologic toxicity was common, but DI was excellent. Concurrent preoperative RT is safe, although an increased rate of grade 4 thrombocytopenia and limited increase in wound complications may be observed.

scholarly journals Three-phase scintigraphy in evaluation of preoperative chemotherapy of soft tissue sarcomas of extremities

2019 ◽  
Vol 3 (28) ◽  
pp. 33-38
Author(s):  
Ya. A. Shchipakhina ◽  
A. S. Krylov ◽  
N. V. Kochergina ◽  
L. E. Rotobelskaya ◽  
A. B. Bludov ◽  
...  
Keyword(s):  
Soft Tissue ◽  
Preoperative Chemotherapy ◽  
Soft Tissues ◽  
Soft Tissue Sarcomas ◽  
Diagnostic Value ◽  
Pathologic Response ◽  
Negative Results ◽  
Three Phase ◽  
Before And After ◽  
Grade Iii

Purpose. To determine the diagnostic value of threephase scintigraphy in the evaluation of the preoperative chemotherapy of soft tissue sarcomas of the extremities on different diagnostic stages. Material and methods. We analyzed the data of 76 patients with extremity soft tissue sarcomas. The study included data from 28 patients who underwent three-phase scintigraphy with Technetril 99mTc. Scintigraphic data before and after neoadjuvation chemotherapy were analyzed in 16 patients, before and during chemotherapy — in 6 patients, only during chemotherapy — in 1 and only after all courses of chemotherapy — in 5 patients. Results. The sensitivity of the method (prediction of grade III–IV pathologic response) was 100 %, specificity (prediction of grade I–II pathologic response) was 87%. The predictive value of positive and negative results was 63 and 100%, respectively. Conclusion. A three-phase scintigraphy with Technetril 99mTc is a highly informative method for evaluating the effectiveness of preoperative chemotherapy in patients with sarcomas of soft tissues of the extremities.

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