scholarly journals Three-phase scintigraphy in evaluation of preoperative chemotherapy of soft tissue sarcomas of extremities

2019 ◽  
Vol 3 (28) ◽  
pp. 33-38
Author(s):  
Ya. A. Shchipakhina ◽  
A. S. Krylov ◽  
N. V. Kochergina ◽  
L. E. Rotobelskaya ◽  
A. B. Bludov ◽  
...  
Keyword(s):  
Soft Tissue ◽  
Preoperative Chemotherapy ◽  
Soft Tissues ◽  
Soft Tissue Sarcomas ◽  
Diagnostic Value ◽  
Pathologic Response ◽  
Negative Results ◽  
Three Phase ◽  
Before And After ◽  
Grade Iii

Purpose. To determine the diagnostic value of threephase scintigraphy in the evaluation of the preoperative chemotherapy of soft tissue sarcomas of the extremities on different diagnostic stages. Material and methods. We analyzed the data of 76 patients with extremity soft tissue sarcomas. The study included data from 28 patients who underwent three-phase scintigraphy with Technetril 99mTc. Scintigraphic data before and after neoadjuvation chemotherapy were analyzed in 16 patients, before and during chemotherapy — in 6 patients, only during chemotherapy — in 1 and only after all courses of chemotherapy — in 5 patients. Results. The sensitivity of the method (prediction of grade III–IV pathologic response) was 100 %, specificity (prediction of grade I–II pathologic response) was 87%. The predictive value of positive and negative results was 63 and 100%, respectively. Conclusion. A three-phase scintigraphy with Technetril 99mTc is a highly informative method for evaluating the effectiveness of preoperative chemotherapy in patients with sarcomas of soft tissues of the extremities.

scholarly journals Early Prediction of Histopathological Tumor Response to Preoperative Chemotherapy by Tc-99m MIBI Imaging in Bone and Soft Tissue Sarcomas

2010 ◽  
Vol 35 (3) ◽  
pp. 154-159 ◽  
Author(s):  
Junichi Taki ◽  
Anri Inaki ◽  
Hiroshi Wakabayashi ◽  
Hisashi Sumiya ◽  
Hiroyuki Tsuchiya ◽  
...  
Keyword(s):  
Soft Tissue ◽  
Preoperative Chemotherapy ◽  
Tumor Response ◽  
Soft Tissue Sarcomas ◽  
Early Prediction

scholarly journals Oral Health and Molecular Aspects of Malignant Fibrous Histiocytoma Patients: A Systematic Review of the Literature

2020 ◽  
Vol 17 (4) ◽  
pp. 1426
Author(s):  
Khrystyna Zhurakivska ◽  
Giuseppe Troiano ◽  
Marco Montella ◽  
Lorenzo Lo Muzio ◽  
Luca Fiorillo ◽  
...  
Keyword(s):  
Systematic Review ◽  
Soft Tissue ◽  
Malignant Fibrous Histiocytoma ◽  
Soft Tissues ◽  
Fibrous Histiocytoma ◽  
Case Reports ◽  
Soft Tissue Sarcomas ◽  
Clinical Aspects ◽  
Risk Of Death ◽  
Short Period

Malignant fibrous histiocytoma is one of the most common soft tissue sarcomas in adults. It occurs only occasionally in oral soft tissues, and knowledge about its characteristics is based on a limited number of cases reported in the literature. Malignant fibrous histiocytoma belongs to the group of soft tissue sarcomas and makes up less than 10% of soft tissue sarcomas. For therapeutic purposes, complete exeresis of the lesion (macroscopic and microscopic) is performed because they have frequent recurrences. As for complementary therapy in addition to surgery, neither radiotherapy nor chemotherapy have been shown to reduce the risk of death related to the disease. Often patients complain of a swelling that grows in a short period of time. It is quite common for patients to report trauma in the area, which is not the cause, but rather the event that allows diagnosis. The mass usually does not cause pain unless it compresses an adjacent nerve structure. The aim of this study is to systematically review the scientific literature in order to identify the most recent studies concerning malignant fibrous histiocytomas localized in oral soft tissues and report their main data. The main outcomes of this study concern the immunohistochemical, molecular, and clinical aspects of this pathology. A systematic review of articles in the electronic databases pubmed, Scopus, and Web of Science was performed. After the selection process, 11 studies met the inclusion criteria and were included in the review. The mean age of the patients was 50.8 years old. The lesions affected various parts of the oral cavity, showing predominantly storiform–pleomorphic patterns. All cases except one were treated with surgical resection and radiation therapy. Although some data emerged from this review, they remain limited to a few case reports. Further studies are necessary in order to standardize the approach to patients affected by oral malignant fibrous histiocytoma (MFH).

The value of thallium and three-phase bone scans in the evaluation of bone and soft tissue sarcomas

1994 ◽  
Vol 21 (11) ◽  
Author(s):  
CalinI. Caluser ◽  
HusseinM. Abdel-Dayem ◽  
HomerA. Macapinlac ◽  
Andrew Scott ◽  
JohnH. Healey ◽  
...  
Keyword(s):  
Soft Tissue ◽  
Soft Tissue Sarcomas ◽  
Three Phase ◽  
Bone Scans

scholarly journals MR Thermometry Data Correlate with Pathological Response for Soft Tissue Sarcoma of the Lower Extremity in a Single Center Analysis of Prospectively Registered Patients

Cancers ◽  
2020 ◽  
Vol 12 (4) ◽  
pp. 959 ◽  
Author(s):  
Michaela Unsoeld ◽  
Ulf Lamprecht ◽  
Frank Traub ◽  
Barbara Hermes ◽  
Marcus Scharpf ◽  
...  
Keyword(s):  
Soft Tissue ◽  
Soft Tissue Sarcoma ◽  
Lower Extremity ◽  
Soft Tissue Sarcomas ◽  
Treatment Temperature ◽  
Pathologic Response ◽  
Preoperative Treatment ◽  
Mr Thermometry ◽  
Hyperthermia Treatment ◽  
Reliable Temperature

Background: There is a strong biologic rationale for using locoregional hyperthermia in soft tissue sarcoma and a randomized trial reported significant improvements with hyperthermia. The aim of this study was to describe the opportunities of magnetic resonance (MR)-based thermometry in a cohort of soft tissue sarcoma patients undergoing combined radiotherapy and locoregional hyperthermia. Patients and Methods: For eleven evaluable patients, tumor volume (VTu) and a separate volume for temperature analysis with reliable temperature distribution (Vtherm) were contoured for every hyperthermia treatment (103 therapies). Temperature data were recorded for all tumors and were correlated with clinical features and pathologic response data. Results: Of 48 patients with high-risk soft tissue sarcomas treated with radio(chemo)therapy and locoregional hyperthermia, MR thermometry was possible in 11 (23%) patients. For all patients, the temperature superseded by 90% of VTu (T90(VTu)) and T90 (Vtherm) were in the range of 37–43 °C and 40–45 °C, respectively. Larger tumors tended to reach higher temperatures. For tumors showing a pathologic response in the resection specimen after preoperative treatment, temperature (T90 (Vtherm)) was significantly higher than in tumors without pathologic response. Conclusion: Lower extremity sarcomas undergoing preoperative treatment with locoregional hyperthermia are especially suitable for MR thermometry. MR thermometry is a promising non-invasive way for temperature measurement during locoregional hyperthermia, showing a positive dose-response relationship.

Sarcoma

2021 ◽  
pp. 95-104
Author(s):  
Ian M. Smith ◽  
Vinay Itte
Keyword(s):  
Soft Tissue ◽  
Clinical Features ◽  
Multidisciplinary Team ◽  
Systematic Approach ◽  
Soft Tissues ◽  
Soft Tissue Sarcomas ◽  
Malignant Tumours ◽  
Staging Classification

Sarcomas are malignant tumours of the soft tissues or bone. Epidemiology, aetiology, pathology, clinical features, investigations, diagnosis, staging, classification, and management of soft tissue sarcomas are described in this chapter. These tumours are relatively uncommon but require a systematic approach to treatment involving a multidisciplinary team.

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