Validation of 18F-FDG PET at Conventional and Delayed Intervals for the Discrimination of High-Grade From Low-Grade Gliomas

2013 ◽  
Vol 38 (7) ◽  
pp. 495-500 ◽  
Author(s):  
Koen Mertens ◽  
Marjan Acou ◽  
Jel Van Hauwe ◽  
Ine De Ruyck ◽  
Caroline Van den Broecke ◽  
...  
Keyword(s):  
Fdg Pet ◽  
Low Grade ◽  
High Grade ◽  
Low Grade Gliomas ◽  
18F Fdg

scholarly journals Glucose Loading Enhances the Value of 18F-FDG PET/CT for the Characterization and Delineation of Cerebral Gliomas

Cancers ◽  
2020 ◽  
Vol 12 (7) ◽  
pp. 1977
Author(s):  
Dongwoo Kim ◽  
Hae Young Ko ◽  
Sangwon Lee ◽  
Yong-ho Lee ◽  
Sujin Ryu ◽  
...  
Keyword(s):  
Fdg Pet ◽  
Characteristic Curve ◽  
Low Grade ◽  
High Grade ◽  
Glucose Loading ◽  
Pet Ct ◽  
Significant Difference ◽  
18F Fdg ◽  
Fdg Pet Ct ◽  
Normal Cortex

This study aimed to assess how to enhance the value of 18F-Fluorodeoxyglucose (FDG) PET/CTs for glioma grading and better delineation of the tumor boundary by glucose loading. In mouse models of brain tumor using U87MG cells, 18F-FDG-PET images were obtained after fasting and after glucose loading. There was a significant difference in the tumor-to-normal cortex-uptake ratio (TNR) between the fasting and glucose-loading scans. 14C-2-Deoxy-D-glucose (14C-DG) uptake was measured in vitro using U87MG, U373MG and primary neurons cultured with different concentrations of glucose. The tumor-to-neuron ratio of 14C-DG uptake increased with up to 10 mM of glucose. Finally, 10 low-grade and 17 high-grade glioma patients underwent fasting and glucose loading 18F-FDG PET/CT and the TNR was compared between scans. The effect of glucose loading was significant in high-grade but not in low-grade gliomas. The receiver operating characteristic curve analyses with a cut-off TNR of 0.81 showed a higher area under the curve after glucose loading than fasting for differentiating low-grade versus high-grade gliomas. In addition, the glucose loading PET/CT was more useful than the fasting PET/CT for the discrimination of oligodendrogliomas from IDH-wildtype glioblastomas. Glucose loading resulted in a greater reduction in 18F-FDG uptake in the normal cortex than in tumors, which increases the usefulness of 18F-FDG PET/CT for grading.

scholarly journals Rare cause of lung atelectasis in a young woman

2019 ◽  
Vol 12 (1) ◽  
pp. e227969
Author(s):  
Paula Inês Pedro ◽  
Dolores Canário ◽  
Miguel Lopes ◽  
Despina Argyropoulou
Keyword(s):  
Surgical Resection ◽  
Fdg Pet ◽  
Mucoepidermoid Carcinoma ◽  
Lower Lobe ◽  
Pathological Examination ◽  
Low Grade ◽  
High Grade ◽  
Pet Ct ◽  
18F Fdg ◽  
Fdg Pet Ct

Pulmonary mucoepidermoid carcinoma is an extremely rare intrathoracic malignancy, comprising less than 1% of all lung tumours. These are very slow growing and are classified into low grade and high grade based on histological features. Surgical resection is the primary treatment with excellent outcomes, while chemotherapy or radiotherapy effectiveness is not known. Preoperative fluorine-18 fluorodeoxyglucose positron emission tomography/CT (18F-FDG PET/CT) is useful for predicting tumour grade and postsurgical prognosis.A clinical case of a 31-year-old woman who presented with dyspnoea on exertion, cough and wheezing is reported. Imaging studies revealed a mass involving the left lower lobe bronchus and atelectasis. 18F-FDG PET/CT showed uptake in the described mass with a maximum standardised uptake value of 9.7. Complete surgical resection was performed, and pathological examination revealed a high-grade mucoepidermoid carcinoma with tumour-free margins. Adjuvant chemotherapy was given and there is no evidence of tumour recurrence.

scholarly journals Role of 18F-FDG PET/CT in Management of High-Grade Salivary Gland Malignancies

2007 ◽  
Vol 48 (8) ◽  
pp. 1237-1244 ◽  
Author(s):  
H.-S. Jeong ◽  
M. K. Chung ◽  
Y.-I. Son ◽  
J. Y. Choi ◽  
H. J. Kim ◽  
...  
Keyword(s):  
Salivary Gland ◽  
Fdg Pet ◽  
High Grade ◽  
Pet Ct ◽  
18F Fdg ◽  
Fdg Pet Ct

scholarly journals Fascicle Sparing Capsular Resections of Atypical Neurofibromas in Neurofibromatosis 1

Neurosurgery ◽  
2019 ◽  
Vol 66 (Supplement_1) ◽  
Author(s):  
Charlie Nelson ◽  
Eva Dombi ◽  
Jared S Rosenblum ◽  
Markku Miettenen ◽  
Tanya Lehky ◽  
...  
Keyword(s):  
Rapid Growth ◽  
Fdg Pet ◽  
Subtotal Resection ◽  
Low Grade ◽  
Volumetric Growth ◽  
Surgical Morbidity ◽  
Histopathological Classification ◽  
Peripheral Nerve Sheath Tumors ◽  
18F Fdg ◽  
Extracapsular Resection

Abstract INTRODUCTION Neurofibromatosis type 1 (NF1) patients are predisposed to neurofibromas (NF), which can progress to premalignant atypical neurofibromas (ANF) and malignant peripheral nerve sheath tumors (MPNST). Subtotal resection of ANF may prevent metastases and deaths, but local recurrences require reoperation. Here, we assess the surgical morbidity associated with gross total, extracapsular resection of targeted ANF nodules identified via serial volumetric magnetic resonance imaging (MRI) and 18F-FDG-PET imaging. METHODS We retrospectively analyzed the clinical outcomes of 11 NF1 patients following 16 NF surgical resections of 21 tumors at the NIH Clinical Center between 2008 and 2018. Preoperative volumetric growth rates and 18F-FDG-PET SUVMAX of the target lesions were measured and assessed in tandem with postoperative complications, histopathological classification of the resected tumors, and surgical margins through Dunnett's multiple comparison tests and t-tests. RESULTS Preoperatively, 13 of the 14 (93%) sets of serial preoperative MRI scans showed rapid growth ( = 20% increase in volume per year), and 10 of the 11 (91%) 18F-FDG-PET scans indicated increased positron emission tomography (PET) avidity (median SUVMax = 6.45). Gross total, extracapsular resections of the targeted neurofibroma nodules were annotated by the surgeon in all 16 (100%) surgeries, and most surgeries (n = 14, 88%) resulted in no persistent postoperative parent nerve-related complications. SUVMax was significantly greater in the ANF (6.51 ± 0.83, P = .0042) and low grade MPNST (13.8, P = .0001) strata than in the benign NF (1.9) stratum. To date, none of the resected NF have recurred. CONCLUSION This study confirms that the combination of increased 18F-FDG-PET SUVMax, rapid growth, and pain can serve as reliable indicators of atypical transformation and the need for surgical intervention. We also demonstrate the ability to achieve safe, fascicle-sparing gross total, extracapsular resection of ANF using intraoperative nerve stimulation, histological verification, and continued monitoring for tumor recurrence.

Diagnostic Values of DCE-MRI and DSC-MRI for Differentiation Between High-grade and Low-grade Gliomas

2018 ◽  
Vol 25 (3) ◽  
pp. 338-348 ◽  
Author(s):  
Jianye Liang ◽  
Dexiang Liu ◽  
Peng Gao ◽  
Dong Zhang ◽  
Hanwei Chen ◽  
...  
Keyword(s):  
Low Grade ◽  
High Grade ◽  
Dce Mri ◽  
Low Grade Gliomas ◽  
Dsc Mri ◽  
Diagnostic Values

scholarly journals Qualitative analysis of spinal intramedullary lesions using PET/CT

2015 ◽  
Vol 23 (5) ◽  
pp. 613-619 ◽  
Author(s):  
Kentaro Naito ◽  
Toru Yamagata ◽  
Hironori Arima ◽  
Junya Abe ◽  
Naohiro Tsuyuguchi ◽  
...  
Keyword(s):  
Fdg Pet ◽  
Proliferation Index ◽  
Low Grade ◽  
Tumor Proliferation ◽  
High Grade ◽  
Pet Ct ◽  
Grade Malignancy ◽  
High Grade Malignancy ◽  
Met Pet ◽  
Mib 1

OBJECT Although the usefulness of PET for brain lesions has been established, few reports have examined the use of PET for spinal intramedullary lesions. This study investigated the diagnostic utility of PET/CT for spinal intramedullary lesions. METHODS l-[methyl-11C]-methionine (MET)- or [18F]-fluorodeoxyglucose (FDG)-PET/CT was performed in 26 patients with spinal intramedullary lesions. The region of interest (ROI) within the spinal cord parenchyma was placed manually in the axial plane. Maximum pixel counts in the ROIs were normalized to the maximum standardized uptake value (SUVmax) using subject body weight. For FDG-PET the SUVmax was corrected for lean body mass (SULmax) to exclude any influence of the patient’s body shape. Each SUV was analyzed based on histopathological results after surgery. The diagnostic validity of the SUV was further compared with the tumor proliferation index using the MIB-1 monoclonal antibody (MIB-1 index). RESULTS A total of 16 patients underwent both FDG-PET and MET-PET, and the remaining 10 patients underwent either FDG-PET or MET-PET. Pathological diagnoses included high-grade malignancy such as glioblastoma multiforme, anaplastic astrocytoma, or anaplastic ependymoma in 5 patients; low-grade malignancy such as hemangioblastoma, diffuse astrocytoma, or ependymoma in 12 patients; and nonneoplastic lesion including cavernous malformation in 9 patients. Both FDG and MET accumulated significantly in high-grade malignancy, and the SULmax and SUVmax correlated with the tumor proliferation index. Therapeutic response after chemotherapy or radiation in high-grade malignancy was well monitored. However, a significant difference in SULmax and SUVmax for FDG-PET and MET-PET was not evident between low-grade malignancy and nonneoplastic lesions. CONCLUSIONS Spinal PET/CT using FDG or MET for spinal intramedullary lesions appears useful and practical, particularly for tumors with high-grade malignancy. Differentiation of tumors with low-grade malignancy from nonneoplastic lesions may still prove difficult. Further technological refinement, including the selection of radiotracer or analysis evaluation methods, is needed.

scholarly journals Comparison of Intravoxel Incoherent Motion Diffusion-Weighted MR Imaging and Arterial Spin Labeling MR Imaging in Gliomas

2015 ◽  
Vol 2015 ◽  
pp. 1-10 ◽  
Author(s):  
Yuankai Lin ◽  
Jianrui Li ◽  
Zhiqiang Zhang ◽  
Qiang Xu ◽  
Zhenyu Zhou ◽  
...  
Keyword(s):  
Diffusion Coefficient ◽  
White Matter ◽  
Mr Imaging ◽  
Arterial Spin Labeling ◽  
Spin Labeling ◽  
Intravoxel Incoherent Motion ◽  
Low Grade ◽  
High Grade ◽  
Low Grade Gliomas ◽  
High Grade Gliomas

Gliomas grading is important for treatment plan; we aimed to investigate the application of intravoxel incoherent motion (IVIM) diffusion-weighted imaging (DWI) in gliomas grading, by comparing with the three-dimensional pseudocontinuous arterial spin labeling (3D pCASL). 24 patients (13 high grade gliomas and 11 low grade gliomas) underwent IVIM DWI and 3D pCASL imaging before operation; maps of fast diffusion coefficient (D∗), slow diffusion coefficient (D), fractional perfusion-related volume (f), and apparent diffusion coefficient (ADC) as well as cerebral blood flow (CBF) were calculated and then coregistered to generate the corresponding parameter values. We found CBF andD∗were higher in the high grade gliomas, whereas ADC,D, andfwere lower (allP<0.05). In differentiating the high from low grade gliomas, the maximum areas under the curves (AUC) ofD∗, CBF, and ADC were 0.857, 0.85, and 0.902, respectively. CBF was negatively correlated withfin tumor (r=-0.619,P=0.001). ADC was positively correlated withDin both tumor and white matter (r=0.887,P=0.000andr=0.824,P=0.000, resp.). There was no correlation between CBF andD∗in both tumor and white matter (P>0.05). IVIM DWI showed more efficiency than 3D pCASL but less validity than conventional DWI in differentiating the high from low grade gliomas.

scholarly journals Classification and Treatment of Pediatric Gliomas in the Molecular Era

Children ◽  
2021 ◽  
Vol 8 (9) ◽  
pp. 739
Author(s):  
Peter Hauser
Keyword(s):  
Wide Spectrum ◽  
High Grade Glioma ◽  
Tumor Grade ◽  
Primary Treatment ◽  
Low Grade ◽  
High Grade ◽  
Therapeutic Approaches ◽  
Term Survival ◽  
Low Grade Gliomas ◽  
Leading Role

The overall survival of pediatric gliomas varies over a wide spectrum depending on the tumor grade. Low-grade gliomas have an excellent long-term survival, with a possible burden of surgery, irradiation, and chemotherapy; in contrast, high-grade gliomas generally have a short-term, devastating lethal outcome. Recent advances in understanding their molecular background will transform the classification and therapeutic approaches of pediatric gliomas. Molecularly targeted treatments may acquire a leading role in the primary treatment of low-grade gliomas and may provide alternative therapeutic strategies for high-grade glioma cases in the attempt to avoid the highly unsuccessful conventional therapeutic approaches. This review aims to overview this progress.

scholarly journals Antibiotic Allergy and Blood Eosinophils Percent Could Be Prognostic Indicators of Glioma

2021 ◽  
Author(s):  
Liming Cao ◽  
Zhanghua Lv ◽  
Weiliang Wang ◽  
Xue Li ◽  
Jing Shi ◽  
...  
Keyword(s):  
Regression Analysis ◽  
Cox Regression ◽  
Tumor Grade ◽  
Blood Eosinophil ◽  
Low Grade ◽  
High Grade ◽  
Cox Regression Analysis ◽  
Low Grade Gliomas ◽  
Antibiotic Allergy ◽  
High Grade Gliomas

Abstract Background: Antibiotic allergy and blood eosinophil percentage (EOS%) may play an important role in the prognosis of gliomas, but few studies reported the relationship between antibiotic allergy and glioma as well as EOS% and glioma. The aim of our study was to estimate the relationships between antibiotic allergy, blood eosinophil percentage (EOS%) and glioma prognosis and to conduct a nomogram model for glioma patients. Estimating the effect of antibiotic allergy and EOS% on glioma prognosis may conduce to finding low-cost and safe prognostic indicators of glioma.Methods: We conducted a retrospective cohort study with 656 glioma patients to estimate the associations between antibiotic allergy, EOS% and glioma prognosis by Kaplan-Meier and Cox regression analysis. Stratified analyses were performed according to tumor grade. We constructed a nomogram with age at diagnosis, gender, tumor grade, antibiotic allergy, EOS% to predict the survival probabilities of glioma. Results: During 12 months follow-up, a total of 227 patients were alive and 318 patients died. Antibiotic allergy and EOS% >1.65 conferred a survival advantage on glioma patients. In the stratified analysis by tumor grade, antibiotic allergy was significantly associated with the prognosis of the prognosis of low-grade gliomas (HR = 0.36, 95%CI: 0.13-0.97) and high-grade gliomas (HR = 0.58, 95%CI: 0.36-0.93) in the univariate Cox regression analysis. However, after adjusting for confounding factors in the multivariate Cox regression analysis, antibiotic allergy was only significantly associated with high-grade gliomas (HRadj = 0.50, 95%CI: 0.30-0.82); the relationship between EOS% and glioma prognosis was restricted to low-grade gliomas (HRadj = 0.50, 95%CI: 0.30-0.82). The C-index of nomogram was 0.74.Conclusions: Antibiotic allergy was a protective prognosis factor of high-grade gliomas, EOS% >1.65 was a protective prognosis factor of low-grade gliomas. The nomogram with antibiotic allergy and EOS% could effectively predict the survival probability of glioma.

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