scholarly journals Impact of Different Ventilation Strategies on Gas Exchanges and Circulation During Prolonged Mechanical Cardio-Pulmonary Resuscitation In A Porcine Model

Shock ◽  
2021 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Caroline Fritz ◽  
Deborah Jaeger ◽  
Yun Luo ◽  
Emilie Lardenois ◽  
Bilal Badat ◽  
...  
Keyword(s):  
Porcine Model ◽  
Gas Exchanges ◽  
Cardio Pulmonary Resuscitation ◽  
Ventilation Strategies

scholarly journals Impact of Different Ventilation Strategies on Gas Exchanges and Circulation During Prolonged Mechanical Cardio-Pulmonary Resuscitation in a Porcine Model

2021 ◽  
Author(s):  
Caroline FRITZ ◽  
Deborah JAEGER ◽  
Yun LUO ◽  
Emilie LARDENOIS ◽  
Bilal BADAT ◽  
...  
Keyword(s):  
Cerebral Perfusion ◽  
Porcine Model ◽  
Minute Ventilation ◽  
Control Mode ◽  
Low Flow ◽  
Volume Control ◽  
Arterial Oxygen ◽  
Arterial Blood ◽  
Cardio Pulmonary Resuscitation ◽  
Ventilation Strategies

Abstract Background: Optimal ventilation during cardio-pulmonary resuscitation (CPR) is still controversial. Ventilation is expected to provide sufficient arterial oxygen content and adequate carbon dioxide removal, while minimizing the risk of circulatory impairment. The objective of the present study was to compare three ventilation strategies in a porcine model during mechanical continuous chest compressions (CCC) according to arterial oxygenation and hemodynamic impact. MethodVentricular fibrillation was induced and followed by five no-flow minutes and thirty low-flow minutes resuscitation with mechanical-CCC without vasopressive drugs administration. Three groups of eight Landras pig were randomized according to the ventilation strategy: i) Standard volume-control mode (SD-group); ii) bi-level pressure mode (CPV-group); iii) continuous insufflation with Boussignac Cardiac-Arrest Device (BC-group). We assessed i) arterial blood gases, ii) macro hemodynamics, iii) tissular cerebral macro and micro-circulation and iiii) airway pressure, minute ventilation at baseline and every five minutes during the protocol. Results: Arterial PaO2 level was higher at each measurement time in SD-group (>200mmHg) compare to CPV-group and BC-group (p<0.01). In BC-group, arterial PaCO2 level was significantly higher (>90mmHg) than in SD and CPV groups (p<0.01). There was no difference between groups concerning hemodynamic parameters, cerebral perfusion and microcirculation. Conclusion: Ventilation modalities in this porcine model of prolonged CPR influence oxygenation and decarboxylation without impairing circulation and cerebral perfusion.

695: Impact of Arterial and Arteriovenous Renal Clamping with and without Intrarenal Cooling on Renal Oxygenation and Temperature in a Porcine Model

2007 ◽  
Vol 177 (4S) ◽  
pp. 233-233
Author(s):  
Alexandra E. Perks ◽  
Trevor D. Schuler ◽  
Luke Fazio ◽  
Brian Blew ◽  
Greg Hare ◽  
...  
Keyword(s):  
Porcine Model

877: The Effect of Arterial Versus Arteriovenous Clamping on Renal Tissue Oxygenation in a Porcine Model

2006 ◽  
Vol 175 (4S) ◽  
pp. 283-284
Author(s):  
Luke M. Fazio ◽  
Alexandra E. Perks ◽  
Brian D.M. Blew ◽  
Greg T. Hare ◽  
David Mazer ◽  
...  
Keyword(s):  
Tissue Oxygenation ◽  
Porcine Model ◽  
Renal Tissue

637: Establishing a Porcine Model for the Accelerated Development of Cancer Vaccines for Patients with Metastatic Renal Cell Carcinoma

2005 ◽  
Vol 173 (4S) ◽  
pp. 173-174
Author(s):  
Quinton V. Cancel ◽  
Benjamin K. Yang ◽  
Zhen Su ◽  
Jens Dannull ◽  
Philipp Dahm ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Metastatic Renal Cell Carcinoma ◽  
Renal Cell ◽  
Cancer Vaccines ◽  
Porcine Model

44: Laparoscopic Augmentation Cystoplasty: A Comparison between Native Ileum Versus Small Intestinal Submucosa in the Porcine Model

2004 ◽  
Vol 171 (4S) ◽  
pp. 12-12
Author(s):  
David A. Anderson ◽  
David S. Wang ◽  
Peter C. Fretz ◽  
Thai T. Nguyen ◽  
Howard N. Winfield
Keyword(s):  
Porcine Model ◽  
Small Intestinal Submucosa ◽  
Augmentation Cystoplasty ◽  
Small Intestinal ◽  
Intestinal Submucosa
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