The effect of Iridoids effective fraction of Valeriana jatamansi Jones on movement function in rats after acute cord injury and the related mechanism

Neuroreport ◽  
2021 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Deqi Xiong ◽  
Hao Liu ◽  
Rizhao Pang ◽  
Zhiyong Yan ◽  
Nianyi Sun ◽  
...  
Keyword(s):  
Effective Fraction ◽  
Valeriana Jatamansi ◽  
Cord Injury ◽  
Movement Function

scholarly journals Effects of repetitive magnetic stimulation on motor function and expression of GAP-43 and 5-HT in rats with spinal cord injury

2020 ◽  
Author(s):  
Hao Liu ◽  
Deqi Xiong ◽  
Wenchun Wang ◽  
Li Yuan ◽  
Rizhao Pang ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Motor Function ◽  
Magnetic Stimulation ◽  
Expression Levels ◽  
Cord Injury ◽  
Post Operation ◽  
Movement Function ◽  
Apoptosis Related Protein

Abstract Objectives: Spinal cord injury (SCI) is a disastrous central nervous system (CNS) disorder. The aim of this study was to explore the effects of repetitive trans-spinal magnetic stimulation (rTSMS) act on different segments of the spinal cord on movement function and expression of GAP43 and 5-HT in rats after acute cord injury and to preliminarily discuss the best treatment site of rTSMS, so as to provide theoretical foundation and experimental evidence for the clinical application of rTSMS in spinal cord injury. Methods: In the present study, we used a rat model of T10 laminectomy with transient violent oppression by aneurysm clip. The rats were classified into A group (sham surgery), B group (acute SCI without stimulation), C group (T6 segment stimulation), D group (T10 segment stimulation) and E group (L2 segment stimulation). Results: In vivo the magnetic stimulation was found to protect motor function and alleviate myelin sheath damage, decrease the expression levels of NgR and Nogo-A, increase the expression levels of growth-associated protein-43 (GAP43) and 5-hydroxytryptamine (5-HT), and inhibite TUNEL-positive cells as well as the expressions of apoptosis-related protein of rats following 8 weeks post-operation.Conclusions: This study suggests that rTSMS can promote the expression of GAP-43 and 5-HT and axonal regeneration in the spinal cord which is beneficial to the recovery of motor function after acute spinal cord injury.

New AAC Access Strategy for Gesture Tracking: A Technical Note

2012 ◽  
Vol 21 (1) ◽  
pp. 11-16 ◽  
Author(s):  
Susan Fager ◽  
Tom Jakobs ◽  
David Beukelman ◽  
Tricia Ternus ◽  
Haylee Schley
Keyword(s):  
Augmentative And Alternative Communication ◽  
Technical Note ◽  
Head Tracking ◽  
Alternative Communication ◽  
Access Methods ◽  
Cord Injury ◽  
Physical Limitations ◽  
Gesture Tracking ◽  
Communication Needs ◽  
Tracking Device

Abstract This article summarizes the design and evaluation of a new augmentative and alternative communication (AAC) interface strategy for people with complex communication needs and severe physical limitations. This strategy combines typing, gesture recognition, and word prediction to input text into AAC software using touchscreen or head movement tracking access methods. Eight individuals with movement limitations due to spinal cord injury, amyotrophic lateral sclerosis, polio, and Guillain Barre syndrome participated in the evaluation of the prototype technology using a head-tracking device. Fourteen typical individuals participated in the evaluation of the prototype using a touchscreen.

Impairment Rating and Spinal Cord Injuries: Revisiting the Guides

2010 ◽  
Vol 15 (3) ◽  
pp. 1-7
Author(s):  
Richard T. Katz
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injuries ◽  
Functional Independence ◽  
Outcome Data ◽  
Multiple Organ ◽  
Loss Of Function ◽  
Sixth Edition ◽  
Organ Systems ◽  
Cord Injury ◽  
Impairment Ratings

Abstract This article addresses some criticisms of the AMA Guides to the Evaluation of Permanent Impairment (AMA Guides) by comparing previously published outcome data from a group of complete spinal cord injury (SCI) persons with impairment ratings for a corresponding level of injury calculated using the AMA Guides, Sixth Edition. Results of the comparison show that impairment ratings using the sixth edition scale poorly with the level of impairments of activities of daily living (ADL) in SCI patients as assessed by the Functional Independence Measure (FIM) motor scale and the extended FIM motor scale. Because of the combinations of multiple impairments, the AMA Guides potentially overrates the impairment of paraplegics compared with that of quadriplegics. The use and applicability of the Combined Values formula should be further investigated, and complete loss of function of two upper extremities seems consistent with levels of quadriplegia using the SCI model. Some aspects of the AMA Guides contain inconsistencies. The concept of diminishing impairment values is not easily translated between specific losses of function per organ system and “overall” loss of ADLs involving multiple organ systems, and the notion of “catastrophic thresholds” involving multiple organ systems may support the understanding that variations in rating may exist in higher rating cases such as those that involve an SCI.

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