High-resolution imaging with high and ultra high-field magnetic resonance imaging systems

Neuroreport ◽  
2008 ◽  
Vol 19 (1) ◽  
pp. 7-13 ◽  
Author(s):  
Tsutomu Nakada ◽  
Hitoshi Matsuzawa ◽  
Ingrid L. Kwee
2009 ◽  
Vol 44 (7) ◽  
pp. 375-383 ◽  
Author(s):  
Gregory A. Christoforidis ◽  
Ming Yang ◽  
Marinos S. Kontzialis ◽  
Douglas G. Larson ◽  
Amir Abduljalil ◽  
...  

2020 ◽  
Author(s):  
Robert L. Barry ◽  
Suma Babu ◽  
Sheeba Arnold Anteraper ◽  
Christina Triantafyllou ◽  
Boris Keil ◽  
...  

AbstractAmyotrophic lateral sclerosis (ALS) is a neurodegenerative disease of the central nervous system that results in a progressive loss of motor function and ultimately death. It is crit-ical, yet also challenging, to develop non-invasive biomarkers to identify, localize, measure and/or track biological mechanisms implicated in ALS. Such biomarkers may also provide clues to identify potential molecular targets for future therapeutic trials. Herein we report on twelve participants with ALS and nine age-matched healthy controls who underwent high-resolution resting state functional magnetic resonance imaging at an ultra-high field of 7 Tesla. Group-level whole-brain analyses revealed a disruption in long-range functional connectivity between the superior sensorimotor cortex (in the precentral gyrus) and bi-lateral cerebellar lobule VI. Post hoc analyses using atlas-derived left and right cerebellar lobule VI revealed decreased functional connectivity in ALS participants that predomi-nantly map to bilateral postcentral and precentral gyri. Cerebellar lobule VI is a transition zone between anterior motor networks and posterior non-motor networks in the cerebellum, and has been associated with a wide range of key functions including complex motor and cognitive processing tasks. Our observation of the involvement of cerebellar lobule VI adds to the growing number of studies implicating the cerebellum in ALS. Future avenues of scientific investigation should consider how high-resolution imaging at 7T may be leveraged to visualize differences in functional connectivity disturbances in various genotypes and phenotypes of ALS along the ALS-frontotemporal dementia spectrum.


2020 ◽  
Vol 16 (S5) ◽  
Author(s):  
Alexa Haeger ◽  
Arthur Coste ◽  
Cécile Lerman‐Rabrait ◽  
Julien Lagarde ◽  
Jörg B. Schulz ◽  
...  

2013 ◽  
Vol 39 (4) ◽  
pp. 398-404 ◽  
Author(s):  
D. Slattery ◽  
C. Aland ◽  
G. Durbridge ◽  
G. Cowin

This study reviews the literature on the anatomy of the connective tissues surrounding the distal interphalangeal joint and further characterizes the three-dimensional relationships of these structures with ultra-high field magnetic resonance imaging. Ten cadaver fingers, fixed in a solution of 5% agar and 4% formalin, were imaged utilising an ultrashield 16.4 Tesla ultra-high field magnetic resonance imaging, yielding a total of 4000 images. Images were analysed using Osirix™ (version 5.5.1 32 bit edition) for three-dimensional reconstruction. We found numerous conflicting descriptions of the connective tissue structures around the distal interphalangeal joint. Based upon our literature review and imaging studies we have defined precisely Cleland’s ligaments, the oblique proximal septum, Grayson’s ligaments, the dorsal plate, and the interosseous ligaments of the distal interphalangeal joint.


2011 ◽  
pp. 189-213 ◽  
Author(s):  
Siegfried Trattnig ◽  
Klaus Friedrich ◽  
Wolfgang Bogner ◽  
Klaus Scheffler ◽  
Oliver Bieri ◽  
...  

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