scholarly journals Antimonial analogues of the acridine series. Dilhydrostibacridines

1933 ◽  
Vol 143 (848) ◽  
pp. 38-47 ◽  
Keyword(s):  
Nitro Derivative ◽  
Starting Material ◽  
Arsenic Compounds ◽  
Ring Systems ◽  
Nitrogen Ring ◽  
Derivatives Of

In pursuing our investigation out the antimony analogues of certain nitrogen ring-systems, we Lave now succeeded in obtaining derivatives of dilhydrostibacridines, of when some of the corresponding arsenic compounds have been studied recently by Gump and Stolzenburg. The starting material for the work was o -aminodiphenylmethane obtained from the corresponding nitro derivative when, in turn, was prepared from o -nitrobenzyl chloride and benzene by Taneseseu's modification of the Friedel-Crafts reaction.

scholarly journals Preparation and Reactions of Sulfur-Nitrogen Ring Systems

1976 ◽  
Vol 31 (5) ◽  
pp. 680-683 ◽  
Author(s):  
Herbert W. Roesky
Keyword(s):  
Sulfur Atom ◽  
Starting Material ◽  
Structure And Properties ◽  
Tetrahedral Configuration ◽  
Ring Systems ◽  
X Ray ◽  
Kinetically Controlled ◽  
Planar Molecule ◽  
Bonding Properties ◽  
Nitrogen Ring

Two routes for the preparation of (CH3)2SnS2N2 are given, which are kinetically controlled reactions. The molecule (CH3)2SnS2N2 was characterized by X-ray analysis. It is an interesting starting material for the preparation of S2N2CO and S3N2O. The latter reacts with iminosulfur oxides and isocyanates under the formation of S3N3SO2F and S3N3SO2CF3. The structure of S3N3SO2F was established by X-ray analysis. The bonding properties are discussed.The cleavage of thin-nitrogen derivatives with S3N2Cl2 yields also five membered sulfurnitrogen rings. The structure and properties of P3N3F5NS3N2 and C3N3F2NS3N2 are reported. Six, eight and ten membered rings are formed by the reactions of(CH3)3Si–N = S = N–Si (CH3)3with FSO2–N=S=O, these are S4N4O2 and S5N5+S3N3O4, respectively. The cation S5N5+ is a planar molecule, while the oxygen containing species are puckered. In S4N4O2 the oxygens are attached to one sulfur atom, which has a tetrahedral configuration.The structure of the silicon containing cyclic and bicyclic rings (CH3)2Si(NSN)2Si(CH3)2 and CH3Si(NSN)3SiCH3 were determined.

SYNTHESIS OF 1,1,1-TRICHLORO-2,2-BIS-(p-CYANOPHENYL)-ETHANE

1952 ◽  
Vol 30 (3) ◽  
pp. 203-207 ◽  
Author(s):  
Yvon Perron ◽  
Roger Barré
Keyword(s):  
Condensation Product ◽  
Starting Material ◽  
Derivatives Of

The synthesis of 1,1,1-trichloro-2,2-bis-(p-cyanophenyl)-ethane was carried out with the condensation product of chloral and toluene as starting material. This product was converted, through the corresponding tetraacetate, to 1,1,1-trichloro-2,2-bis-(p-aldehydophenyl)-ethane which in turn reacted with hydroxylamine to give the dioxime. The subsequent dehydration of the latter gave rise to the desired dinitrile. The corresponding dichloro derivatives of the oxime and nitrile were also prepared.

Circular dichroism of benzylidene derivatives of glycerol and mannitol

1977 ◽  
Vol 30 (11) ◽  
pp. 2465 ◽  
Author(s):  
RM Carman ◽  
CJ Hawkins ◽  
JJ Kibby
Keyword(s):  
Circular Dichroism ◽  
Ring Systems ◽  
Cotton Effects ◽  
Derivatives Of ◽  
Circular Dichroïsm

The c.d. spectra are reported for a series of benzylidene derivatives of glycerol and mannitol containing 1,3-dioxolan, 1,3-dioxan and 1,3- dioxepan ring systems. The signs of the Cotton effects of 1Lb and 1La transitions of the phenyl chromophore have been rationalized in terms of recently proposed sector rules for these transitions.

The binding of analogues of coralyne and related heterocyclics to DNA triplexes

1995 ◽  
Vol 73 (1-2) ◽  
pp. 11-18 ◽  
Author(s):  
Laura J. P. Latimer ◽  
Natasha Payton ◽  
Gavin Forsyth ◽  
Jeremy S. Lee
Keyword(s):  
Thermal Denaturation ◽  
Positive Charge ◽  
Triplex Dna ◽  
Alkyl Chains ◽  
Dna Triplexes ◽  
Weak Binding ◽  
Related Alkaloid ◽  
General Preference ◽  
Nitrogen Ring ◽  
Derivatives Of

Coralyne has been shown previously to bind well to both T∙A∙T- and C∙G∙C+-containing triplexes. Derivatives of coralyne were prepared and their binding to poly(dT)∙poly(dA)∙poly(dT) and poly[d(TC)]∙poly[d(GA)]∙poly[d(C+T)] was assessed from thermal denaturation profiles. A tetraethoxy derivative showed only weak binding to both types of triplex. Analogues with extended 8-alkyl chains showed good binding to poly(dT)∙poly(dA)∙poly(dT), but the preference for triplex poly[d(TC)]∙poly[d(GA)]∙poly[d(C+T)] was decreased compared with the duplex. Sanguinarine, a related alkaloid, bound well to poly(dT)∙poly(dA)∙poly(dT) but only weakly to the protonated triplex. It is hypothesized that the position of the protonated nitrogen ring is important for binding to poly[d(TC)]∙poly[d(GA)]∙poly[d(C+T)]. A series of other chromophores was studied and only those with a positive charge bound to triplexes. All of these bound well to poly(dT)∙poly(dA)∙poly(dT) but only weakly if at all to the duplex poly(dA)∙poly(dT). In contrast, most of them did not bind well to the triplex poly[d(TC)]∙poly[d(GA)]∙poly[d(C+T)] and those that did still showed a preference for duplex poly[d(TC)]∙poly[d(GA)]. In general, preference for triplex poly(dT)∙poly(dA)∙poly(dT) compared with the duplex is a common feature of intercalating drugs. On the other hand, specificity for protonated triplexes may be very difficult to achieve.Key words: triplex DNA, DNA-binding drugs, intercalation.

ChemInform Abstract: CONDENSED THIOPHEN RING SYSTEMS PART 16, DERIVATIVES OF 11H-(1)BENZOTHIENO(2,3-B)(1)BENZOTHIOPYRAN

1975 ◽  
Vol 6 (5) ◽  
pp. no-no
Author(s):  
BRIAN IDDON ◽  
HANS SUSCHITZKY ◽  
DAVID S. TAYLOR ◽  
KEVAN E. CHIPPENDALE
Keyword(s):  
Ring Systems ◽  
Derivatives Of

The Meisenheimer Rearrangement in Heterocyclic Synthesis. IV. Derivatives of the 2H,6H-1,5,4-Benzodioxazocine and 7H-1,6,5-Benzodioxazonine Ring Systems: X-Ray Crystal Structure of 10-Methoxy-5-methyl-7-phenyl-2,3,4,5-tetrahydro-7H-1,6,5-benzodioxazonine

1988 ◽  
Vol 41 (3) ◽  
pp. 293 ◽  
Author(s):  
JB Bremner ◽  
EJ Browne ◽  
LM Engelhardt ◽  
IWK Gunawardana ◽  
AH White
Keyword(s):  
Molecular Structure ◽  
Crystal Structure ◽  
Crystal And Molecular Structure ◽  
Ring System ◽  
Heterocyclic Synthesis ◽  
Rearrangement Product ◽  
Ring Systems ◽  
X Ray ◽  
Derivatives Of ◽  
Moderate Yield

Meisenheimer rearrangement of the N-oxides (4) derived from a series of 5-aryl-4-methyl-2,3,4,5-tetrahydro-1,4-benzoxazepines (3) gave rise to eight derivatives (5) of the new 2H,6H-1,5,4-benzodioxazocine ring system. Reaction of 9-methoxy-5-methyl-6-phenyl-3,4,5,6- tetrahydro-2H-1,5-benzoxazocine (6) with 3-chloroperoxybenzoic acid gave an unstable N-oxide (7). A Meisenheimer rearrangement product from (7), 10-methoxy-5-methyl-7-phenyl-2,3,4,5-tetrahydro-7 H-1,6,5- benzodioxazonine (8), the first example of this ring system, was isolated directly in moderate yield on oxidation of (6) with cooling. The crystal and molecular structure of (8) has been determined by X-ray crystallographic methods.

N,N-Dialkyl-N′-Chlorosulfonyl Chloroformamidines in Heterocyclic Synthesis. III. Pyrido- and Pyridazo-Fused [1,2,4,6]Thiatriazine Dioxides

2007 ◽  
Vol 60 (2) ◽  
pp. 105 ◽  
Author(s):  
Teresa Cablewski ◽  
Erin J. Carter ◽  
Craig L. Francis ◽  
Andris J. Liepa ◽  
Michael V. Perkins
Keyword(s):  
Heterocyclic Synthesis ◽  
Ring Systems ◽  
Derivatives Of

N,N-Dialkyl-N′-chlorosulfonylchloroformamidines 1 reacted with 2-aminopyridines 2 to give novel pyrido[1,2-b][1,2,4,6]thiatriazine dioxides 3 and pyrido[2,1-c][1,2,4,6]thiatriazine dioxides 4. Reaction of 1 with 3-aminopyridazines 5 afforded pyridazo[3,2-c][1,2,4,6]thiatriazine dioxides 6 and a pyridazo[2,3-b][1,2,4,6]thiatriazine dioxide 7. The compounds 6 and 7 are derivatives of new ring systems.

Sign in / Sign up

Export Citation Format

Share Document