SYNTHESIS OF 1,1,1-TRICHLORO-2,2-BIS-(p-CYANOPHENYL)-ETHANE

1952 ◽  
Vol 30 (3) ◽  
pp. 203-207 ◽  
Author(s):  
Yvon Perron ◽  
Roger Barré
Keyword(s):  
Condensation Product ◽  
Starting Material ◽  
Derivatives Of

The synthesis of 1,1,1-trichloro-2,2-bis-(p-cyanophenyl)-ethane was carried out with the condensation product of chloral and toluene as starting material. This product was converted, through the corresponding tetraacetate, to 1,1,1-trichloro-2,2-bis-(p-aldehydophenyl)-ethane which in turn reacted with hydroxylamine to give the dioxime. The subsequent dehydration of the latter gave rise to the desired dinitrile. The corresponding dichloro derivatives of the oxime and nitrile were also prepared.

scholarly journals Antimonial analogues of the acridine series. Dilhydrostibacridines

1933 ◽  
Vol 143 (848) ◽  
pp. 38-47 ◽  
Keyword(s):  
Nitro Derivative ◽  
Starting Material ◽  
Arsenic Compounds ◽  
Ring Systems ◽  
Nitrogen Ring ◽  
Derivatives Of

In pursuing our investigation out the antimony analogues of certain nitrogen ring-systems, we Lave now succeeded in obtaining derivatives of dilhydrostibacridines, of when some of the corresponding arsenic compounds have been studied recently by Gump and Stolzenburg. The starting material for the work was o -aminodiphenylmethane obtained from the corresponding nitro derivative when, in turn, was prepared from o -nitrobenzyl chloride and benzene by Taneseseu's modification of the Friedel-Crafts reaction.

scholarly journals Disodium 5-Cyanoisothiazoledithiolate as a Starting Material for Preparation of New Conductive Solids

1987 ◽  
Vol 42 (8) ◽  
pp. 1050-1051 ◽  
Author(s):  
G. C. Papavassiliou ◽  
G. A. Mousdis ◽  
V. Gionis ◽  
J. S. Zambounis ◽  
S. Y. Yiannopoulos
Keyword(s):  
Cation Radical ◽  
Starting Material ◽  
Derivatives Of

AbstractStarting from disodium 5-cyanoisothiazoledithiolate som e new substituted derivatives of the tetrathiafulvalene and some metal 1,2-dithiolenes with at least an isothiazolo-ring have been prepared. From these com pounds a number of conductive cation radical salts have been obtained.

New Derivatives of Lupeol and Their Biological Activity

Molbank ◽  
10.3390/m1306 ◽  
2021 ◽  
Vol 2021 (4) ◽  
pp. M1306
Author(s):  
Hoang-Thuy-Tien Le ◽  
Quoc-Cuong Chau ◽  
Thuc-Huy Duong ◽  
Quyen-Thien-Phuc Tran ◽  
Nguyen-Kim-Tuyen Pham ◽  
...  
Keyword(s):  
Biological Activity ◽  
Natural Product ◽  
Starting Material ◽  
Chemical Structures ◽  
Spectroscopic Analyses ◽  
Ic50 Value ◽  
Derivatives Of

The natural product lupeol (1) was isolated from Bombax ceiba leaves, which were used as starting material in the semisynthetic approach. Three new derivatives (2a, 2b, and 3) were synthesized using oxidation and aldolization. Their chemical structures were elucidated by spectroscopic analyses (HRESIMS and NMR). Compounds 3 showed significant α-glucosidase inhibition with an IC50 value of 202 µM, whereas 2a and 2b were inactive.

scholarly journals Aerobic oxidation of cumene catalysed by 4-alkyloxycarbonyl-N-hydroxyphthalimide

2014 ◽  
Vol 12 (11) ◽  
pp. 1176-1182 ◽  
Author(s):  
Kornela Kasperczyk ◽  
Beata Orlińska ◽  
Jan Zawadiak
Keyword(s):  
Oxidation Reaction ◽  
Aerobic Oxidation ◽  
Starting Material ◽  
Trimellitic Anhydride ◽  
Cumene Oxidation ◽  
Derivatives Of

Abstract4-Hexyloxycarbonyl-, 4-dodecyloxycarbonyl- and 4-hexadecyloxycarbonyl-N-hydroxyphthalimides were synthesised using trimellitic anhydride chloride as the starting material. The obtained lipophilic derivatives of N-hydroxyphthalimide were applied as catalysts of the cumene oxidation reaction with oxygen performed in polar acetonitrile, in non-polar tert-butylbenzene and in the absence of a solvent. The courses of reactions catalysed by N-hydroxyphthalimide and its derivatives were compared.

1-(4-Cyclopentylphenyl)ethylamine and derivatives: Synthesis and pharmacological screening

1981 ◽  
Vol 46 (9) ◽  
pp. 2234-2244 ◽  
Author(s):  
Zdeněk Vejdělek ◽  
Jiří Holubek ◽  
Marie Bartošová ◽  
Miroslav Protiva
Keyword(s):  
Local Anaesthetic ◽  
Title Compound ◽  
Starting Material ◽  
Ritter Reaction ◽  
Hypotensive Activity ◽  
Substitution Reactions ◽  
Spasmolytic Activity ◽  
Pharmacological Screening ◽  
Neurotropic Effects ◽  
Derivatives Of

Reduction of 4-cyclopentylacetophenone oxime gave the title compound II which was transformed by a combination of acylation, alkylation, reduction and substitution reactions to compounds III-XI. 2-Benzylcyclopentanone oxime was reduced to 2-benzylcyclopentylamine (XVI) and converted by a reaction with methylmagnesium iodide and by the following Ritter reaction to the formamide derivative XVIII which was used as the starting material for preparing amines XIX-XXI. The local anaesthetic and spasmolytic activity were the most typical neurotropic effects of derivatives of compound II. 2-Benzyl-1-methylcyclopentylamine and derivatives XIX-XXI have some hypotensive activity.

The Stability and Conformation of the 1,3,6,8-Tetraazatricyclo[4.4.1.13,8]dodecane System: the Structure of the Condensation Product of 1,2-Diaminocyclohexane and Formaldehyde

1975 ◽  
Vol 53 (13) ◽  
pp. 1933-1935 ◽  
Author(s):  
P. Murray-Rust ◽  
F. G. Riddell
Keyword(s):  
Structure Analysis ◽  
Condensation Product ◽  
Optically Active ◽  
Starting Material ◽  
Analogous Reaction ◽  
X Ray ◽  
The Stability

The condensation of d,1-trans-1,2-diaminocyclohexane with formaldehyde gives a pentacyclic molecule based on the 1,3,6,8-tetraazatricyclo[4.4.1.13,8]dodecane nucleus. This was shown to have S4 symmetry by 1H n.m.r. and an X-ray analysis showed crystals to be orthorhombic, Fddd, a = 12.02, b = 19.25, c = 12.90 Å. The symmetry of the compound in the crystal was D2d due to a disordered arrangement and structure analysis was carried out to R = 0.166. When optically active diamine was used as starting material, the analogous reaction did not occur and this was attributed to strain in the tricyclic system. The conformation of the molecule is related to those of similar compounds as found by X-ray analysis.

Preparation and Characterisation of Iodo-functionalised Azobenzene Derivatives of the Type I–p-C6H4–N=N–p-C6H4–X

2008 ◽  
Vol 63 (12) ◽  
pp. 1395-1401 ◽  
Author(s):  
Ulrich Siemeling ◽  
Clemens Bruhn ◽  
Mario Meier ◽  
Christian Schirrmacher
Keyword(s):  
Single Crystal ◽  
Structure Analysis ◽  
General Type ◽  
Starting Material ◽  
Type I ◽  
X Ray Diffraction ◽  
Ferrocene Derivative ◽  
X Ray ◽  
Derivatives Of ◽  
Azobenzene Derivatives

A broad range of azobenzene derivates of the general type I-p-C6H4-N=N-p-C6H4-X (1) have been prepared. In the case of X = Ph (b), C≡C-Fc (e, Fc = ferrocenyl), OMe (g), Oi-Pr (i), and NMe2 (m), these compounds have been characterised by single-crystal X-ray structure analysis. In addition, the closely related 4-dimethylamino-1-(4-iodophenylazo)naphthalene 2 and 8-(4-iodophenylazo) quinoline 3 have also been prepared. Furthermore, the ferrocene derivative Fc-C≡C-p-C6H4- NH2 (4), which served as a starting material for the synthesis of I-p-C6H4-N=N-p-C6H4-p-C6H4- C≡C-Fc (1e), was prepared and structurally characterised by X-ray diffraction.

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