scholarly journals II. On the anatomy of the connective tissues

1875 ◽  
Vol 23 (156-163) ◽  
pp. 184-187
Keyword(s):  
Blood Serum ◽  
Aqueous Humour ◽  
Animal Tissues ◽  
Connective Tissues ◽  
Cover Glass ◽  
Horizontal Section

Transparent animal tissues, when sealed up fresh in aqueous humour or blood-serum, by running Brunswick black round the edge of the cover glass, undergo a series of slow changes, by which, generally within a period of 2 to 5 days, anatomical elements mostly otherwise invisible become distinct. The paper is chiefly a record of observations made by this method. The author shows:— After a horizontal section of the cornea has been sealed up for about 2 hours, the stellate branched cells are seen to consist of a mass of pro-tlasma, sharply defined on every side, except where it is continued for scarcely perceptible distance into the processes. The nucleus is flatted.

scholarly journals I. Note on the changes effected by digestion on fibrinogen and fibrin

1888 ◽  
Vol 43 (258-265) ◽  
pp. 367-368
Keyword(s):  
Blood Serum ◽  
Blood Plasma ◽  
Animal Tissues ◽  
Almost All ◽  
In Blood Plasma

Fibrinogen is a name conveniently given to a group of proteid substances which can all be converted under certain conditions into fibrin. They exist in blood plasma (in traces in certain kinds of blood serum), and they can be prepared from almost all animal tissues (thymus, testis, brain, liver, kidney, stroma of red corpuscles, &c.).

Markers of melanoma progression in the blood serum structure.

2019 ◽  
Vol 37 (15_suppl) ◽  
pp. e21035-e21035
Author(s):  
Alla I. Shikhlyarova ◽  
Oleg I. Kit ◽  
Olga N. Shatokhina ◽  
Amira A. Akhmedova ◽  
Yury Valentinovich Przhedetskiy ◽  
...  
Keyword(s):  
Solid State ◽  
Blood Serum ◽  
Prognostic Markers ◽  
Treatment Effectiveness ◽  
Polarized Light ◽  
Cover Glass ◽  
Early Appearance ◽  
M Proteins ◽  
Cell Dehydration ◽  
Extracellular Environment

e21035 Background: Lack of prognostic markers of melanoma to assess its progression, metastasis (MTS), and treatment effectiveness, determines the feasibility of studying biophysical aspects of the transmission of events from cellular to extracellular environment. Receipt and circulation of pathological proteins of melanoma (M) in the blood carries important information, and its trap is the phase transition of biofluids into a solid state. The purpose of the study was to determine markers of melanoma at the supramolecular level in solid-state samples of the blood serum (BS). Methods: 240 samples of BS obtained prior to the surgery from 60 patients with M were studied. The preparations were prepared by the Shatokhina-Shabalin method by creating a closed "analytic cell": dehydration of a BS drop (10 mcL) under a cover glass at 20–240С, humidity 65–70%, for 72 hours. The folding of M proteins was assessed by a polarized light microscopy (Leica DM LS2 microscope, x400-640) using photo and video control and the Morphotest program. Results: The initial stages of M development were characterized by the early appearance of single combined melanoform crystals — anisotropic microspherolites (Mi) embedded in the center of a large anisomorphone (lAM). As M progressed, Mi aggregation with basic lAMs was enhanced. Anisotropy of Mi increased, revealing clear sectors filled with melanin. In the later stages of M growth, melanoform aggregations dominated with point, filamentous, and chained melanin structures. The manifestation of MTS was accompanied by the destruction of the aggregations and the filling of the analytic cell space with numerous Mi. Conclusions: Correspondence of crystallogenesis of M melanomorphic markers in BS in tumor progression allows using the studied supramolecular factors to predict the development of melanoma.

Elemental composition of aqueous humour and blood serum at various levels of intraocular pressure

2016 ◽  
Vol 132 (6) ◽  
pp. 43 ◽  
Author(s):  
A. P. Ermolaev ◽  
I. A. Novikov ◽  
L. I. Mel’nikova ◽  
I. G. Griboedova ◽  
K. S. Avetisov
Keyword(s):  
Intraocular Pressure ◽  
Blood Serum ◽  
Elemental Composition ◽  
Aqueous Humour

Banded Structures in the Connective Tissue of Meningioma

1976 ◽  
Vol 34 ◽  
pp. 234-235
Author(s):  
C. N. Sun ◽  
H. J. White
Keyword(s):  
Connective Tissue ◽  
Osmium Tetroxide ◽  
Uranyl Acetate ◽  
Collagen Fibrils ◽  
Lead Citrate ◽  
Connective Tissues ◽  
Native Collagen ◽  
Routine Procedures

Previously, we have reported on extracellular cross-striated banded structures in human connective tissues of a variety of organs (1). Since then, more material has been examined and other techniques applied. Recently, we studied a fibrocytic meningioma of the falx. After the specimen was fixed in 4% buffered glutaraldehyde and post-fixed in 1% buffered osmium tetroxide, other routine procedures were followed for embedding in Epon 812. Sections were stained with uranyl acetate and lead citrate. There were numerous cross striated banded structures in aggregated bundle forms found in the connecfive tissue of the tumor. The banded material has a periodicity of about 450 Å and where it assumes a filamentous arrangement, appears to be about 800 Å in diameter. In comparison with the vicinal native collagen fibrils, the banded material Is sometimes about twice the diameter of native collagen.

Relationships between hierarchical structure and properties in macromolecular systems

1987 ◽  
Vol 45 ◽  
pp. 440-443
Author(s):  
E. Baer
Keyword(s):  
Uniaxial Tension ◽  
Hierarchical Structure ◽  
Inorganic Material ◽  
Hierarchical Structures ◽  
Bone Collagen ◽  
Structure And Properties ◽  
Connective Tissues ◽  
Scale Level ◽  
Fibrous Protein ◽  
Macromolecular Systems

The most advanced macromolecular materials are found in plants and animals, and certainly the connective tissues in mammals are amongst the most advanced macromolecular composites known to mankind. The efficient use of collagen, a fibrous protein, in the design of both soft and hard connective tissues is worthy of comment. Very crudely, in bone collagen serves as a highly efficient binder for the inorganic hydroxyappatite which stiffens the structure. The interactions between the organic fiber of collagen and the inorganic material seem to occur at the nano (scale) level of organization. Epitatic crystallization of the inorganic phase on the fibers has been reported to give a highly anisotropic, stress responsive, structure. Soft connective tissues also have sophisticated oriented hierarchical structures. The collagen fibers are “glued” together by a highly hydrated gel-like proteoglycan matrix. One of the simplest structures of this type is tendon which functions primarily in uniaxial tension as a reinforced elastomeric cable between muscle and bone.

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