XI. The hereditary blood factors of the Kurds of Iran

Blood specimens were collected from 184 Kurds living in those parts of northwest Iran from which many of the Kurdish Jews, tested in Israel, or their parents, came. Tests were done for the antigens of 10 blood group systems, for the genetic variants of six systems of plasma proteins, and of nine systems of red cell enzymes, and for abnormal haemoglobins. The gene frequencies calculated from the results do not differ greatly from those found in neighbouring populations. They also show a general resemblance to those of the Kurdish Jews, except that the latter have a very much higher incidence of glucose 6-phosphate dehydrogenase deficiency. The possible reasons for this marked difference affecting one genetic system only, are discussed.

Blood specimens were collected in the Negev, Israel, from 75 Yemenite Jews and 121 Kurdish Jews, who were also subjected to a variety of measurements and physiological tests. The specimens were tested for the antigens of 10 blood group systems, for the genetic variants of four systems of plasma proteins and of eight systems of red-cell enzymes. The gene frequencies calculated from the results show that these two Jewish populations differ widely from one another genetically. The Yemenite Jews show a rather close resemblance to the Yemenite Arabs. The Kurdish Jews show a fair resemblance to the indigenous Kurds of Iran, but differ markedly in having a very much higher incidence of glucose 6-phosphate dehydrogenase deficiency. As there are reasons for thinking that, in general, a high incidence of this deficiency results from natural selection in response to endemic malarial infection, the marked difference between Kurdish Jews and the indigenous Kurds who were for many generations their close neighbours is difficult to explain.


1974 ◽  
Vol 16 (3) ◽  
pp. 691-695 ◽  
Author(s):  
Lina Lucciola ◽  
Hiroko Kaita ◽  
Jeanne Anderson ◽  
Sandra Emery

A random sample of Cree Indian women of child-bearing age was examined for their phenotypes in 17 blood group and 21 enzyme systems. Eleven of the blood group systems and ten of the enzyme systems proved to be polymorphic. The observed phenotypes and calculated gene frequencies are reported.


2018 ◽  
Vol 98 (1) ◽  
pp. 83-87 ◽  
Author(s):  
Tamar E. Carter ◽  
Karen Lopez ◽  
Seleshi Kebede Mekonnen ◽  
Lambodhar Damodaran ◽  
Victoria Bonnell ◽  
...  

Hematology ◽  
2005 ◽  
Vol 2005 (1) ◽  
pp. 19-23 ◽  
Author(s):  
Josef T. Prchal ◽  
Xylina T. Gregg

Abstract Mutations leading to red cell enzyme deficiencies can be associated with diverse phenotypes that range from hemolytic anemia, methemoglobinemia, polycythemia, and neurological and developmental abnormalities. While most of these mutations occur sporadically, some such as common glucose-6-phosphate dehydrogenase (G6PD) mutants are endemic and rarely cause disease. Common G6PD mutants likely reached their prevalence because they provide some protection against severe malarial complications. In this review G6PD, pyruvate kinase, 5′ nucleotidase, and cytochrome b5 reductase deficiencies will be discussed in greater detail. Limitations of commonly used screening tests for detection of these disorders will also be emphasized, as well as emerging knowledge about non-enzymatic function of the glycolytic enzymes.


1975 ◽  
Vol 55 (4) ◽  
pp. 875-878 ◽  
Author(s):  
H N Kirkman ◽  
G D Gaetani ◽  
E H Clemons ◽  
C Mareni

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