scholarly journals Identification of a new promoter in the early region of the human papillomavirus type 16 genome

1999 ◽  
Vol 80 (12) ◽  
pp. 3241-3250 ◽  
Author(s):  
T. H. Braunstein ◽  
B. S. Madsen ◽  
B. Gavnholt ◽  
M. W. Rosenstierne ◽  
C. Koefoed Johnsen ◽  
...  
Keyword(s):  
Human Papillomavirus ◽  
Control Synthesis ◽  
Start Site ◽  
Late Gene Expression ◽  
Transcription Start ◽  
Transcription Start Sites ◽  
Polycistronic Mrna ◽  
Human Papillomavirus Type 16 ◽  
E6 And E7 ◽  
E7 Proteins

Transcription of the human papillomavirus type 16 (HPV-16) genome is controlled by several promoters; the P97 promoter is considered to be the main one. An additional promoter has been identified within the E7 ORF as well as an antisense promoter just upstream of the L2 ORF. The significance of these promoters for early and late gene expression and their activity related to cell differentiation is not known in detail. Identification of two new, previously undescribed transcription start sites at nt 542 just upstream of the E7 ORF and at nt 611 within the E7 ORF is reported. The promoter responsible for the start site at nt 542 (P542) was active in SiHa, HeLa and C33A cells. Very low promoter activity was found upstream of the nt 611 start site. The E7 protein has previously been shown to be synthesized from a polycistronic mRNA encoding both the E6 and E7 proteins under the control of the P97 promoter. The data reported in the present paper suggest that promoter P542 may control synthesis of the E7 oncoprotein from a monocistronic mRNA.

scholarly journals Identification of Antibodies against Human Papillomavirus Type 16 E6 and E7 Proteins in Sera of Patients with Cervical Neoplasias

1992 ◽  
Vol 83 (7) ◽  
pp. 705-713 ◽  
Author(s):  
Toshiyuki Sasagawa ◽  
Masaki Inoue ◽  
Osamu Tanizawa ◽  
Masuo Yutsudo ◽  
Akira Hakura
Keyword(s):  
Human Papillomavirus ◽  
Human Papillomavirus Type 16 ◽  
E6 And E7 ◽  
E7 Proteins

Antibodies against Human Papillomavirus Type 16 and 18 E6 and E7 Proteins in Cervicovaginal Washings and Serum of Patients with Cervical Neoplasia

2001 ◽  
Vol 14 (4) ◽  
pp. 415-424 ◽  
Author(s):  
M.Y. Tjiong ◽  
K. Zumbach ◽  
J. ter Schegget ◽  
N. van der Vange ◽  
T.A. Out ◽  
...  
Keyword(s):  
Human Papillomavirus ◽  
Cervical Neoplasia ◽  
Human Papillomavirus Type 16 ◽  
E6 And E7 ◽  
E7 Proteins

Serologic response to the E4, E6, and E7 proteins of human papillomavirus type 16 in pregnant women

1998 ◽  
Vol 178 (2) ◽  
pp. 360-364 ◽  
Author(s):  
Shneh Sethi ◽  
Martin Müller ◽  
Achim Schneider ◽  
Maria Blettner ◽  
Elaine Smith ◽  
...  
Keyword(s):  
Human Papillomavirus ◽  
Pregnant Women ◽  
Human Papillomavirus Type 16 ◽  
Serologic Response ◽  
E6 And E7 ◽  
E7 Proteins

E6 and E7 Oncoproteins from Human Papillomavirus Type 16 Induce Activation of Human Transforming Growth Factorβ1Promoter throughout Sp1 Recognition Sequence

2006 ◽  
Vol 19 (3) ◽  
pp. 468-480 ◽  
Author(s):  
Oscar Peralta-Zaragoza ◽  
Víctor Bermúdez-Morales ◽  
Lourdes Gutiérrez-Xicotencatl ◽  
Juan Alcocer-González ◽  
Félix Recillas-Targa ◽  
...  
Keyword(s):  
Human Papillomavirus ◽  
Recognition Sequence ◽  
Human Papillomavirus Type 16 ◽  
E6 And E7 Oncoproteins ◽  
E6 And E7
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