scholarly journals Antibody response to outer-membrane antigens of Pseudomonas aeruginosa in human burn wound infection

1988 ◽  
Vol 27 (3) ◽  
pp. 179-190 ◽  
Author(s):  
K. H. WARD ◽  
H. ANWAR ◽  
M. R. W. BROWN ◽  
J. WALE ◽  
J. GOWAR
1983 ◽  
Vol 42 (1) ◽  
pp. 88-98 ◽  
Author(s):  
J S Lam ◽  
L M Mutharia ◽  
R E Hancock ◽  
N Høiby ◽  
K Lam ◽  
...  

1985 ◽  
Vol 29 (3) ◽  
pp. 225-230 ◽  
Author(s):  
Hosmin Anwar ◽  
Geoffrey H. Shand ◽  
Kathryn H. Ward ◽  
Michael R.W. Brown ◽  
Kaya E. Alpar ◽  
...  

2012 ◽  
Vol 19 (5) ◽  
pp. 659-665 ◽  
Author(s):  
Elizabeth E. Moran ◽  
Robert Burden ◽  
Joseph E. Labrie ◽  
Zhiyun Wen ◽  
Xin-Min Wang ◽  
...  

ABSTRACTRabbit immunogenicity studies on an experimental trivalent native outer membrane vesicle vaccine derived from three serogroup B strains were conducted to evaluate the effectiveness of this vaccine at inducing an antibody response with serum bactericidal activity against meningococcal strains of other serogroups in addition to serogroup B strains. The results showed that the vaccine was capable of inducing an effective broad-based bactericidal antibody response in rabbits against a small sample ofNeisseria meningitidisstrains of serogroups C, W135, and X and, to a lesser extent, serogroups A and Y. Analysis of antibody specificity using a bactericidal depletion assay revealed that antibodies to lipooligosaccharide (LOS), PorA, and NadA induced in rabbits by the experimental trivalent outer membrane vesicle vaccine were responsible for most of the bactericidal activity against strains of the otherN. meningitidisserogroups. In the case of serogroup AN. meningitidisstrains, the outer membrane antigen NadA was primarily responsible for protection. The outer membrane antigens fHbp and OpcA were also effective in removing some bactericidal activity from the sera.


2013 ◽  
Vol 51 (4) ◽  
pp. 151
Author(s):  
Syed Hassan Abbas Naqvi ◽  
Syed Hassan Shiraz Naqvi ◽  
E Coetzee

Sign in / Sign up

Export Citation Format

Share Document