scholarly journals Relapse of enterococcal prosthetic valve endocarditis with aortic rootabscess following treatment with daptomycin in a patient not fit for surgery

2010 ◽  
Vol 59 (4) ◽  
pp. 482-485 ◽  
Author(s):  
D. A. Enoch ◽  
N. Phillimore ◽  
J. A. Karas ◽  
L. Horswill ◽  
D. A. Mlangeni

Daptomycin is a novel lipopeptide with activity against Gram-positive organismsincluding enterococci. It is licensed for the treatment of Staphylococcusaureus bacteraemia and right-sided endocarditis, but not endocarditisdue to Enterococcus spp. We report a case of enterococcal prostheticvalve endocarditis with an aortic root abscess in an elderly patient who wasnot fit for surgery. The patient's endocarditis relapsed 9 weeks aftera 6 week course of daptomycin.

Author(s):  
Back Liam M ◽  
Magdy Joseph ◽  
Guiney Liam ◽  
Luo Roger ◽  
Hussein Akram ◽  
...  

Perfusion ◽  
2017 ◽  
Vol 32 (5) ◽  
pp. 383-388 ◽  
Author(s):  
Apostolos Roubelakis ◽  
Dimos Karangelis ◽  
Syed Sadeque ◽  
Bobby Yanagawa ◽  
Amit Modi ◽  
...  

Introduction: The treatment of complex prosthetic valve endocarditis (PVE) with aortic root abscess remains a surgical challenge. Several studies support the use of biological tissues to minimize the risk of recurrent infection. We present our initial surgical experience with the use of an aortic xenograft conduit for aortic valve and root replacement. Methods: Between October 2013 and August 2015, 15 xenograft bioconduits were implanted for complex PVE with abscess (13.3% female). In 6 patients, concomitant procedures were performed: coronary bypass (n=1), mitral valve replacement (n=5) and tricuspid annuloplasty (n=1). The mean age at operation was 60.3±15.5 years. The mean Logistic European system for cardiac operating risk evaluation (EuroSCORE) was 46.6±23.6. The median follow-up time was 607±328 days (range: 172-1074 days). Results: There were two in-hospital deaths (14.3% mortality), two strokes (14.3%) and seven patients required permanent pacemaker insertion for conduction abnormalities (46.7%). The mean length of hospital stay was 26 days. At pre-discharge echocardiography, the conduit mean gradient was 9.3±3.3mmHg and there was either none (n=6), trace (n=6) or mild aortic insufficiency (n=1). There was no incidence of mid-term death, prosthesis-related complications or recurrent endocarditis. Conclusions: Xenograft bioconduits may be safe and effective for aortic valve and root replacement for complex PVE with aortic root abscess. Although excess early mortality reflects the complexity of the patient population, there was good valve hemodynamics, with no incidence of recurrent endocarditis or prosthesis failure in the mid-term. Our data support the continued use and evaluation of this biological prosthesis in this high-risk patient cohort.


2015 ◽  
Vol 15 (5) ◽  
pp. 326-328 ◽  
Author(s):  
Dafna Yahav ◽  
Israel Kuznitz ◽  
Sharon Reisfeld ◽  
Noa Eliakim-Raz ◽  
Jihad Bishara

2003 ◽  
Vol 51 (12) ◽  
pp. 681-684 ◽  
Author(s):  
Keiichi Fujiwara ◽  
Hiroki Hayashi ◽  
Shuji Yamamoto ◽  
Hiroyoshi Komai ◽  
Yoshitaka Okamura

CHEST Journal ◽  
2021 ◽  
Vol 160 (4) ◽  
pp. A295
Author(s):  
Sanu Rajendraprasad ◽  
Dorothy Kenny ◽  
Rosa Cruz Torres ◽  
Manasa Velagapudi

Author(s):  
Kanne Padmaja ◽  
Vemu Lakshmi ◽  
Mallempati Amaresh ◽  
Ramesh Mishra ◽  
Rosy Chikkala ◽  
...  

2016 ◽  
Vol 43 (1) ◽  
pp. 20-28 ◽  
Author(s):  
Kaan Kirali ◽  
Sabit Sarikaya ◽  
Yucel Ozen ◽  
Hakan Sacli ◽  
Eylul Basaran ◽  
...  

Aortic root abscess is the most severe sequela of infective endocarditis, and its surgical management is a complicated procedure because of the high risk of morbidity and death. Twenty-seven patients were included in this 15-year retrospective study: 21 (77.8%) with native- and 6 (22.2%) with prosthetic-valve endocarditis. The surgical reconstruction of the aortic root consisted of aortic valve replacement in 19 patients (70.4%) with (11) or without (8) a pericardial patch, or total aortic root replacement in 7 patients (25.9%); 5 of the 27 (18.5%) underwent the modified Bentall procedure with the flanged conduit. Only one patient (3.7%) underwent subaortic pericardial patch reconstruction without valve replacement. A total of 7 patients (25.9%) underwent reoperation: 6 with prior valve surgery, and 1 with prior isolated sinus of Valsalva repair. The mean follow-up period was 6.8 ± 3.7 years. There were 6 (22.2%) in-hospital deaths, 3 (11.1%) of which were perioperative, among patients who underwent emergent surgery. Five patients (23.8%) died during follow-up, and the overall survival rates at 1, 5, and 10 years were 70.3% ± 5.8%, 62.9% ± 6.4%, and 59.2% ± 7.2%, respectively. Two of 21 patients (9.5%) underwent reoperation because of paravalvular leakage and early recurrence of infection during follow-up. After complete resection of the perianular abscess, replacement of the aortic root can be implemented for reconstruction of the aortic root, with or without left ventricular outflow tract injuries. Replacing the aortic root with a flanged composite graft might provide the best anatomic fit.


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