TRIM5 genotypes in cynomolgus monkeys primarily influence inter-individual diversity in susceptibility to monkey-tropic human immunodeficiency virus type 1
2013 ◽
Vol 94
(6)
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pp. 1318-1324
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Keyword(s):
TRIM5α restricts human immunodeficiency virus type 1 (HIV-1) infection in cynomolgus monkey (CM) cells. We previously reported that a TRIMCyp allele expressing TRIM5–cyclophilin A fusion protein was frequently found in CMs. Here, we examined the influence of TRIM5 gene variation on the susceptibility of CMs to a monkey-tropic HIV-1 derivative (HIV-1mt) and found that TRIMCyp homozygotes were highly susceptible to HIV-1mt not only in vitro but also in vivo. These results provide important insights into the inter-individual differences in susceptibility of macaques to HIV-1mt.
2001 ◽
Vol 75
(8)
◽
pp. 3916-3924
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2000 ◽
Vol 74
(17)
◽
pp. 7699-7707
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2005 ◽
Vol 79
(21)
◽
pp. 13579-13586
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2000 ◽
Vol 74
(1)
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pp. 184-192
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2001 ◽
Vol 75
(23)
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pp. 11344-11353
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1999 ◽
Vol 73
(8)
◽
pp. 6670-6679
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1999 ◽
Vol 73
(9)
◽
pp. 7368-7375
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1999 ◽
Vol 73
(5)
◽
pp. 4485-4488
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