scholarly journals Insufficient Mitigation of Bone Loss by Zoledronic Acid after Treatment with Denosumab

2021 ◽  
Vol 28 (4) ◽  
pp. 339-341
Author(s):  
Jung-Wee Park
Keyword(s):  
Zoledronic Acid ◽  
Bone Loss

ZOLEDRONIC ACID AS ADJUNCT TO ANDROGEN DEPRIVATION THERAPY REDUCES BONE LOSS IN MEN WITH PROSTATE CANCER

2006 ◽  
Vol 5 (2) ◽  
pp. 57 ◽  
Author(s):  
R. Casey ◽  
W. Love ◽  
C. Mendoza ◽  
D. Reymond ◽  
M. Zarenda
Keyword(s):  
Prostate Cancer ◽  
Zoledronic Acid ◽  
Bone Loss ◽  
Androgen Deprivation Therapy ◽  
Androgen Deprivation

Comparison of the effects of genistein and zoledronic acid on the bone loss in OPG-deficient mice

Bone ◽  
2008 ◽  
Vol 42 (5) ◽  
pp. 950-959 ◽  
Author(s):  
Jianghua Liu ◽  
Kang Xu ◽  
Gebo Wen ◽  
Hui Guo ◽  
San Li ◽  
...  
Keyword(s):  
Zoledronic Acid ◽  
Bone Loss ◽  
Deficient Mice

Zoledronic Acid Prevents Cancer Treatment–Induced Bone Loss in Premenopausal Women Receiving Adjuvant Endocrine Therapy for Hormone-Responsive Breast Cancer: A Report From the Austrian Breast and Colorectal Cancer Study Group

2007 ◽  
Vol 25 (7) ◽  
pp. 820-828 ◽  
Author(s):  
Michael F.X. Gnant ◽  
Brigitte Mlineritsch ◽  
Gero Luschin-Ebengreuth ◽  
Stephan Grampp ◽  
Helmut Kaessmann ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Zoledronic Acid ◽  
Bone Loss ◽  
Endocrine Therapy ◽  
Premenopausal Women ◽  
Adjuvant Endocrine Therapy ◽  
Phase Iii ◽  
Endocrine Treatment ◽  
Mineral Density ◽  
T Score

Purpose Adjuvant therapy for breast cancer can be associated with decreased bone mineral density (BMD) that may lead to skeletal morbidity. This study examined whether zoledronic acid can prevent bone loss associated with adjuvant endocrine therapy in premenopausal patients. Patients and Methods This study is a randomized, open-label, phase III, four-arm trial comparing tamoxifen (20 mg/d orally) and goserelin (3.6 mg every 28 days subcutaneously) ± zoledronic acid (4 mg intravenously every 6 months) versus anastrozole (1 mg/d orally) and goserelin ± zoledronic acid for 3 years in premenopausal women with hormone-responsive breast cancer. In a BMD subprotocol at three trial centers, patients underwent serial BMD measurements at 0, 6, 12, 24, and 36 months. Results Four hundred one patients were included in the BMD subprotocol. Endocrine treatment without zoledronic acid led to significant (P < .001) overall bone loss after 3 years of treatment (BMD, −14.4% after 36 months; mean T score reduction, −1.4). Overall bone loss was significantly more severe in patients receiving anastrozole/goserelin (BMD, −17.3%; mean T score reduction, −2.6) compared with patients receiving tamoxifen/goserelin (BMD, −11.6%; mean T score reduction, −1.1). In contrast, BMD remained stable in zoledronic acid–treated patients (P < .0001 compared with endocrine therapy alone). No interactions with age or other risk factors were noted. Conclusion Endocrine therapy caused significant bone loss that increased with treatment duration in premenopausal women with breast cancer. Zoledronic acid 4 mg every 6 months effectively inhibited bone loss. Regular BMD measurements and initiation of concomitant bisphosphonate therapy on evidence of bone loss should be considered for patients undergoing endocrine therapy.

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