Potent optogenetic inhibition of behavior with anion channelrhodopsins
Keyword(s):
AbstractOptogenetics employs light exposure to manipulate physiology in genetically modified organisms. There are abundant tools for optogenetic excitation of neuronal activity, but the limitations of current activity photo-inhibitors present an obstacle to demonstrating the necessity of specific neuronal circuits. Here we show that anion channelrhodopsins can be used to specifically and rapidly inhibit a range of systems involved in Drosophila locomotion, wing expansion, memory retrieval and gustation, demonstrating their broad utility to the circuit analysis of behavior.
2015 ◽
Vol 2015
(1)
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pp. 19-1-19-8
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2014 ◽
2016 ◽