scholarly journals Pulmonary Lymphatics Are Primary Sites of Mycobacterium tuberculosis Infection in Guinea Pigs Infected by Aerosol

2006 ◽  
Vol 74 (9) ◽  
pp. 5397-5401 ◽  
Author(s):  
Randall J. Basaraba ◽  
Erin E. Smith ◽  
Crystal A. Shanley ◽  
Ian M. Orme
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Lymph Nodes ◽  
Guinea Pigs ◽  
Low Dose ◽  
Latent Infection ◽  
Tuberculosis Infection ◽  
Mycobacterium Tuberculosis Infection ◽  
Regional Lymph Nodes

ABSTRACT Mycobacterium tuberculosis causes a lymphatic vasculitis in the lungs of guinea pigs infected by a low-dose aerosol. This observation suggests that in addition to being a direct conduit from the lungs to the regional lymph nodes, pulmonary lymphatics are themselves sites of infection and could be the site of latent infection.

Ag85b/ESAT6-CFP10 adjuvanted with aluminum/poly-IC effectively protects guinea pigs from latent mycobacterium tuberculosis infection

Vaccine ◽  
2019 ◽  
Vol 37 (32) ◽  
pp. 4477-4484 ◽  
Author(s):  
Chunhua Wang ◽  
Jinbiao Lu ◽  
Weixin Du ◽  
Guozhi Wang ◽  
Xuguang Li ◽  
...  
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Guinea Pigs ◽  
Tuberculosis Infection ◽  
Mycobacterium Tuberculosis Infection

scholarly journals Disparate effects of metformin on Mycobacterium tuberculosis infection in diabetic and non-diabetic mice

2020 ◽  
Author(s):  
Harindra D. Sathkumara ◽  
Karyna Hansen ◽  
Socorro Miranda-Hernandez ◽  
Brenda Govan ◽  
Catherine M. Rush ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Mycobacterium Tuberculosis ◽  
Disease Burden ◽  
Low Dose ◽  
Tuberculosis Infection ◽  
Diabetic Mice ◽  
Mycobacterium Tuberculosis Infection ◽  
Therapeutic Concentration ◽  
Global Control

AbstractComorbid type 2 diabetes poses a great challenge to the global control of tuberculosis. Here we assessed the efficacy of metformin (MET); an anti-diabetic drug, in mice infected with a very-low dose of Mycobacterium tuberculosis. In contrast to diabetic mice, infected non-diabetic mice that received the same therapeutic concentration of MET presented with significantly higher disease burden. This warrants further studies to investigate the disparate efficacy of MET against tuberculosis in diabetic and non-diabetic individuals.

scholarly journals Experimental Mycobacterium tuberculosis Infection of Cynomolgus Macaques Closely Resembles the Various Manifestations of Human M. tuberculosis Infection

2003 ◽  
Vol 71 (10) ◽  
pp. 5831-5844 ◽  
Author(s):  
Saverio V. Capuano ◽  
Denise A. Croix ◽  
Santosh Pawar ◽  
Angelica Zinovik ◽  
Amy Myers ◽  
...  
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Immune Responses ◽  
Nonhuman Primates ◽  
Low Dose ◽  
Latent Tuberculosis ◽  
Tuberculosis Infection ◽  
Mycobacterium Tuberculosis Infection ◽  
Full Spectrum ◽  
Tuberculin Skin Test Conversion ◽  
Cynomolgus Macaques

ABSTRACT Nonhuman primates were used to develop an animal model that closely mimics human Mycobacterium tuberculosis infection. Cynomolgus macaques were infected with low doses of virulent M. tuberculosis via bronchoscopic instillation into the lung. All monkeys were successfully infected, based on tuberculin skin test conversion and peripheral immune responses to M. tuberculosis antigens. Progression of infection in the 17 monkeys studied was variable. Active-chronic infection, observed in 50 to 60% of monkeys, was characterized by clear signs of infection or disease on serial thoracic radiographs and in other tests and was typified by eventual progression to advanced disease. Approximately 40% of monkeys did not progress to disease in the 15 to 20 months of study, although they were clearly infected initially. These monkeys had clinical characteristics of latent tuberculosis in humans. Low-dose infection of cynomolgus macaques appears to represent the full spectrum of human M. tuberculosis infection and will be an excellent model for the study of pathogenesis and immunology of this infection. In addition, this model will provide an opportunity to study the latent M. tuberculosis infection observed in ∼90% of all infected humans.

scholarly journals Lymph nodes are sites of prolonged bacterial persistence during Mycobacterium tuberculosis infection in macaques

2018 ◽  
Vol 14 (11) ◽  
pp. e1007337 ◽  
Author(s):  
Sharie Keanne C. Ganchua ◽  
Anthony M. Cadena ◽  
Pauline Maiello ◽  
Hannah P. Gideon ◽  
Amy J. Myers ◽  
...  
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Lymph Nodes ◽  
Tuberculosis Infection ◽  
Bacterial Persistence ◽  
Mycobacterium Tuberculosis Infection

scholarly journals IL-10 Impairs Local Immune Response in Lung Granulomas and Lymph Nodes during Early Mycobacterium tuberculosis Infection

2019 ◽  
Vol 204 (3) ◽  
pp. 644-659 ◽  
Author(s):  
Eileen A. Wong ◽  
Stephanie Evans ◽  
Carolyn R. Kraus ◽  
Kathleen D. Engelman ◽  
Pauline Maiello ◽  
...  
Keyword(s):  
Immune Response ◽  
Mycobacterium Tuberculosis ◽  
Lymph Nodes ◽  
Tuberculosis Infection ◽  
Local Immune Response ◽  
Mycobacterium Tuberculosis Infection

scholarly journals Uptake and Accumulation of Oxidized Low-Density Lipoprotein during Mycobacterium tuberculosis Infection in Guinea Pigs

PLoS ONE ◽  
2012 ◽  
Vol 7 (3) ◽  
pp. e34148 ◽  
Author(s):  
Gopinath S. Palanisamy ◽  
Natalie M. Kirk ◽  
David F. Ackart ◽  
Andrés Obregón-Henao ◽  
Crystal A. Shanley ◽  
...  
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Guinea Pigs ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Tuberculosis Infection ◽  
Low Density ◽  
Oxidized Low Density Lipoprotein ◽  
Mycobacterium Tuberculosis Infection
Sign in / Sign up

Export Citation Format

Share Document