scholarly journals LinCoM: a graph theoretic approach for the production of Linear place fields in Complex Mazes

2020 ◽  
Author(s):  
Christoforos A. Papasavvas

AbstractStudies on spatial coding and episodic memory typically involve recordings of hippocampal place cell activity while rodents navigate in mazes. Linear place fields serve as reduced representations of the activity of place cells, revealing their spatial preference along the tracks of the maze. Sometimes, the experimental designs include complex mazes with irregular geometries and one or more decision points. Unfortunately, in such complex mazes, the production of linear place fields becomes a non-trivial problem. Here, I present a MATLAB toolbox which implements a graph-theoretic approach for the efficient production of linear place fields in a variety of complex mazes.

Genetics ◽  
2003 ◽  
Vol 165 (4) ◽  
pp. 2235-2247
Author(s):  
Immanuel V Yap ◽  
David Schneider ◽  
Jon Kleinberg ◽  
David Matthews ◽  
Samuel Cartinhour ◽  
...  

AbstractFor many species, multiple maps are available, often constructed independently by different research groups using different sets of markers and different source material. Integration of these maps provides a higher density of markers and greater genome coverage than is possible using a single study. In this article, we describe a novel approach to comparing and integrating maps by using abstract graphs. A map is modeled as a directed graph in which nodes represent mapped markers and edges define the order of adjacent markers. Independently constructed graphs representing corresponding maps from different studies are merged on the basis of their common loci. Absence of a path between two nodes indicates that their order is undetermined. A cycle indicates inconsistency among the mapping studies with regard to the order of the loci involved. The integrated graph thus produced represents a complete picture of all of the mapping studies that comprise it, including all of the ambiguities and inconsistencies among them. The objective of this representation is to guide additional research aimed at interpreting these ambiguities and inconsistencies in locus order rather than presenting a “consensus order” that ignores these problems.


2020 ◽  
Vol 1706 ◽  
pp. 012115
Author(s):  
P Sangeetha ◽  
M Shanmugapriya ◽  
R Sundareswaran ◽  
K Sowmya ◽  
S Srinidhi

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