scholarly journals Acute radiofrequency electromagnetic radiation exposures cause neuronal DNA damage and impair neurogenesis in the young adolescent rat brain

2020 ◽  
Author(s):  
Kumari Vandana Singh ◽  
Chandra Prakash ◽  
Jay Prakash Nirala ◽  
Ranjan Kumar Nanda ◽  
Paulraj Rajamani
Keyword(s):  
Dna Damage ◽  
Electromagnetic Radiation ◽  
Mobile Phone ◽  
Rat Brain ◽  
Neuronal Degeneration ◽  
Young Adolescent ◽  
Acute Exposure ◽  
And Function ◽  
Lipid Radicals ◽  
Radiofrequency Electromagnetic Radiation

AbstractMobile phone is now a commonly used communication device in all age groups. Young adolescents use it for longer duration and effect of its radiofrequency electromagnetic radiation (RF-EMR) on their brain structure and function need detailed investigation. In the present study, we investigated the effect of RF-EMR emitted from mobile phones, on young adolescent rat brain. Wistar rats (5 weeks, male) were exposed to RF-EMR signal (2,115 MHz) from a mobile phone at a whole body averaged specific absorption rate (SAR) of 1.15 W/kg continuously for 8 h. Higher level of lipid peroxidation, carbon centered lipid radicals and DNA damage were observed in the brain of rat exposed to RF-EMR. Number of neural progenitor cells (NPCs) in dentate gyrus (DG) were found to be relatively low in RF-EMR exposed rats that may be due to reduced neurogenesis. Acute exposure to RF-EMR induced neuronal degeneration in DG region with insignificant variation in CA3, CA1 and cerebral cortex sub regions of hippocampus. Findings of this study, indicate that acute exposure of high frequency RF-EMR at relatively higher SAR may adversely impact the neurogenesis and function of adolescent rat brain. Generation of carbon centered lipid radicals, and nuclear DNA damage might be playing critical role in reduced neurogenesis and higher neuronal degeneration in the cortex and hippocampus of brain. Detailed understanding of RF-EMR induced alteration in brain function will be useful to develop appropriate interventions for reducing the impact caused by RF-EMR damage.

scholarly journals Rab7 Reduces α-Synuclein Toxicity in Rats and Primary Neurons

2021 ◽  
Author(s):  
Éva M. Szegõ ◽  
Eva M. Szegö ◽  
Chris Van den Haute ◽  
Lennart Höfs ◽  
Veerle Baekelandt ◽  
...  
Keyword(s):  
Dna Damage ◽  
Rat Brain ◽  
Neuronal Degeneration ◽  
Degradation Pathway ◽  
Alpha Synuclein ◽  
Dominant Negative ◽  
Primary Neurons ◽  
Vicious Cycle ◽  
Axon Terminals

Abstract BackgroundDuring the pathogenesis of Parkinson’s disease (PD), aggregation of alpha-synuclein (αSyn) induces a vicious cycle of cellular impairments that lead to neurodegeneration. Consequently, removing toxic αSyn aggregates constitutes a plausible strategy against PD. In this work, we tested whether stimulating the autolysosomal degradation of αSyn aggregates through the Ras-related in brain 7 (Rab7) pathway can reverse αSyn-induced cellular impairment and prevent neurodegeneration in vivo.MethodsThe disease-related A53T mutant of αSyn was expressed in primary neurons and in dopaminergic neurons of the rat brain simultaneously with wild type (WT) Rab7 or its dominant-negative T22N mutant as a control. The cellular integrity was quantified by morphological and biochemical analyses.ResultsIn primary neurons, WT Rab7 rescued the αSyn -induced loss of neurons and neurites. Furthermore, Rab7 decreased the amount of reactive oxygen species and the amount of Triton X-100 insoluble αSyn. In rat brain, WT Rab7 reduced αSyn -induced loss of dopaminergic axon terminals in the striatum and the loss of dopaminergic dendrites in the substantia nigra pars reticulata. Further, WT Rab7 lowered αSyn pathology as quantified by phosphorylated αSyn staining. Finally, WT Rab7 attenuated αSyn-induced DNA damage in primary neurons and rat brain.ConclusionRab7 reduced αSyn-induced pathology, ameliorated αSyn-induced neuronal degeneration, oxidative stress and DNA damage. These findings indicate that Rab7 is able to disrupt the vicious cycle of cellular impairment, αSyn pathology and neurodegeneration present in PD. Stimulation of Rab7 and the autolysosomal degradation pathway could therefore constitute a beneficial strategy for PD.

Effect of radiofrequency electromagnetic radiation emitted by mobile phone on trace elements levels in fetal rats

2014 ◽  
Vol 31 (10) ◽  
pp. 174-180
Author(s):  
Yi Zhang ◽  
Kang An ◽  
Mei-Shang Yin ◽  
Long-Long Yin ◽  
Dong-Mei Guo ◽  
...  
Keyword(s):  
Trace Elements ◽  
Electromagnetic Radiation ◽  
Mobile Phone ◽  
Fetal Rats ◽  
Radiofrequency Electromagnetic Radiation

DNA Damage in Rat Brain Cells after In Vivo Exposure to 2450 MHz Electromagnetic Radiation and Various Methods of Euthanasia

1998 ◽  
Vol 149 (6) ◽  
pp. 637 ◽  
Author(s):  
Robert S. Malyapa ◽  
Eric W. Ahern ◽  
Chen Bi ◽  
William L. Straube ◽  
Marie LaRegina ◽  
...  
Keyword(s):  
Dna Damage ◽  
Electromagnetic Radiation ◽  
Rat Brain ◽  
Brain Cells

scholarly journals Effects of radiofrequency electromagnetic radiation (RF-EMF) on honey bee queen development and mating success

2018 ◽  
Author(s):  
Richard Odemer ◽  
Franziska Odemer
Keyword(s):  
Electromagnetic Radiation ◽  
Mobile Phone ◽  
Honey Bee ◽  
Adult Development ◽  
Mating Success ◽  
Colony Development ◽  
List Type ◽  
Colony Losses ◽  
Honey Bee Queen ◽  
Radiofrequency Electromagnetic Radiation

ABSTRACTMobile phones can be found almost everywhere across the globe, upholding a direct point-to-point connection between the device and the broadcast tower. The emission of radiofrequency electromagnetic radiation (RF-EMF) puts the surrounding environment inevitably into contact with this pollutant. We have therefore exposed honey bee queen larvae to the radiation of a common mobile phone device (GSM) during all stages of their pre-adult development including pupation. After 14 days of exposure, hatching of adult queens was assessed and mating success after further 11 days, respectively. Moreover, full colonies were established of five of the untreated and four of the treated queens to contrast population dynamics. We found that mobile phone radiation had significantly reduced the hatching ratio but not the mating success. If treated queens were successfully mated, colony development was not adversely affected. We provide evidence that RF-EMF only acts detrimental within the sensitivity of pupal development, once succeeded this point, no further impairment has manifested in adulthood. Our results are discussed against the background of long-lasting consequences for colony performance and the possible implication on periodic colony losses.HIGHLIGHTSChronic RF-EMF exposure significantly reduced hatching of honey bee queensMortalities occurred during pupation, not at the larval stagesMating success was not adversely affected by the irradiationAfter the exposure, surviving queens were able to establish intact coloniesGRAPHICAL ABSTRACT

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