scholarly journals Evolution of Knockdown Resistance Haplotypes in Response to Pyrethroid Selection in Aedes aegypti

2021 ◽  
Author(s):  
Jennifer Fountain Baltzegar ◽  
Michael Vella ◽  
Christian Gunning ◽  
Gissella Vasquez ◽  
Helvio Astete ◽  
...  
Keyword(s):  
Population Genetics ◽  
Aedes Aegypti ◽  
Genetic Heterogeneity ◽  
Pyrethroid Insecticide ◽  
Direct Connection ◽  
Fine Scale ◽  
Knockdown Resistance ◽  
Incomplete Dominance ◽  
High Selection ◽  
The City

This study describes the evolution of knockdown resistance (kdr) haplotypes in Aedes aegypti in response to pyrethroid insecticide use over the course of 18 years in Iquitos, Peru. Based on the duration and intensiveness of sampling (~10,000 samples), this is the most thorough study of kdr population genetics in Ae. aegypti to date within a city. We provide evidence for the direct connection between programmatic citywide pyrethroid spraying and the increase in frequency of specific kdr haplotypes by identifying two evolutionary events in the population. The relatively high selection coefficients, even under infrequent insecticide pressure, emphasizes how quickly populations can evolve. The observed rapid increase in frequency of resistance alleles might have been aided by the incomplete dominance of resistance-conferring alleles over corresponding susceptibility alleles. In addition to dramatic temporal shifts, spatial suppression experiments reveal that genetic heterogeneity existed not only at the citywide scale, but also on a very fine scale within the city.

Insecticide Resistance Patterns and Mechanisms in Aedes aegypti (Diptera: Culicidae) Populations Across Abidjan, Côte d’Ivoire Reveal Emergent Pyrethroid Resistance

2021 ◽  
Author(s):  
Lucien Yao Konan ◽  
Welbeck Achille Oumbouke ◽  
Urbain Garhapié Silué ◽  
Ibrahima Zanakoungo Coulibaly ◽  
Jean-Claude Tokou Ziogba ◽  
...  
Keyword(s):  
Aedes Aegypti ◽  
Cote D'ivoire ◽  
Côte D’Ivoire ◽  
Pyrethroid Resistance ◽  
Population Based ◽  
Cote D’Ivoire ◽  
Low Frequencies ◽  
Larval Habitats ◽  
Côte D'ivoire ◽  
The City

Abstract From 2008 to 2017, the city of Abidjan, Côte d’Ivoire experienced several Aedes-borne disease epidemics which required control of the vector mosquito population based on the reduction of larval habitats and insecticidal sprays for adult mosquitoes. This study was undertaken to assess the insecticide susceptibility status of Aedes aegypti (Linnaeus) in the city of Abidjan. Immature Ae. aegypti were sampled from several larval habitats within seven communes of Abidjan and reared to adults. Three to five days old F1 emerged adults were tested for susceptibility using insecticide-impregnated papers and the synergist piperonyl butoxide (PBO) following WHO bioassay guidelines. The results showed that Ae. aegypti populations from Abidjan were resistant to 0.1% propoxur, and 1% fenitrothion, with mortality rates ranging from 0% to 54.2%. Reduced susceptibility (93.4–97.5% mortality) was observed to 0.05% deltamethrin, 0.75% permethrin, 0.05% lambda-cyhalothrin, 5% malathion, and 0.8% chlorpyrifos-methyl. This reduced susceptibility varied depending on the insecticide and the collection site. The restoration of mortality when the mosquitoes were pre-exposed to the synergist PBO suggests that increased activity of oxidases could be contributing to resistance. Three kdr mutations (V410L, V1016I, and F1534C) were present in populations tested, with low frequencies for the Leu410 (0.28) and Ile1016 (0.32) alleles and high frequencies for the Cys1534 allele (0.96). These findings will be used to inform future arbovirus vector control activities in Abidjan.

Inheritance and stability of sodium channel mutations associated with permethrin knockdown resistance in Aedes aegypti

2012 ◽  
Vol 104 (2) ◽  
pp. 136-142 ◽  
Author(s):  
Cheng Chang ◽  
Xin-Yi Huang ◽  
Pin-Chun Chang ◽  
Huai-Hui Wu ◽  
Shu-Mei Dai
Keyword(s):  
Aedes Aegypti ◽  
Sodium Channel ◽  
Knockdown Resistance

scholarly journals Association between Three Mutations, F1565C, V1023G and S996P, in the Voltage-Sensitive Sodium Channel Gene and Knockdown Resistance in Aedes aegypti from Yogyakarta, Indonesia

Insects ◽  
2015 ◽  
Vol 6 (3) ◽  
pp. 658-685 ◽  
Author(s):  
Juli Wuliandari ◽  
Siu Lee ◽  
Vanessa White ◽  
Warsito Tantowijoyo ◽  
Ary Hoffmann ◽  
...  
Keyword(s):  
Aedes Aegypti ◽  
Sodium Channel ◽  
Knockdown Resistance ◽  
Channel Gene ◽  
Sodium Channel Gene

scholarly journals Genetic structure of Aedes aegypti in the city of Córdoba (Argentina), a recently reinfested area

2009 ◽  
Vol 104 (4) ◽  
pp. 626-631 ◽  
Author(s):  
Norma B Julio ◽  
Marina B Chiappero ◽  
Hernán J Rossi ◽  
Juan C Rondan Dueñas ◽  
Cristina N Gardenal
Keyword(s):  
Genetic Structure ◽  
Aedes Aegypti ◽  
The City

scholarly journals Avaliação da Presença de Aedes aegypti (Linnaeus) e Aedes albopictus (Skuse) no Município de Vassouras, RJ, Brasil

2014 ◽  
Vol 7 (2) ◽  
pp. 116-123
Author(s):  
Renata Fraga Pinheiro ◽  
Simone Pereira Alves ◽  
Alexandre Araujo Oliveira ◽  
Cleber Barreto Espindola ◽  
Marise Maleck
Keyword(s):  
Aedes Aegypti ◽  
Aedes Albopictus ◽  
The City

Este estudo teve como objetivo verificar a presença das formas imaturas de Aedes aegypti (Linnaeus) e Aedes albopictus (Skuse) no Município de Vassouras, RJ, Brasil. O levantamento foi realizado no período de junho de 2008 a maio de 2010, em sete pontos pré-determinados do município, com coletas semanais utilizando como metodologia de captura de larvas armadilhas de pneus contendo infusão de capim. Os resultados mostraram positividade de Ae. aegypti e Ae. albopictus em todos os pontos analisados e preferencialmente nos meses dezembro, janeiro e março. Evaluating the Presence of Aedes aegypti (Linnaeus) and Aedes albopictus (Skuse) in Vassouras City, RJ, Brazil Abstract. This study aimed to verify the presence of immature forms of Aedes aegypti (Linnaeus) and Aedes albopictus (Skuse) in the Vassouras City, RJ, Brazil. The survey was conducted from June 2008 to May 2010 in seven pre-determined points of the city, with weekly collections using a capturing larval methodology of the traps tires containing grass infusion. The results showed positive for Ae. aegypti and Ae. albopictus at all points analyzed and preferably in the months December, January and March.

scholarly journals The V410L knockdown resistance mutation occurs in island and continental populations of Aedes aegypti in West and Central Africa

2020 ◽  
Vol 14 (5) ◽  
pp. e0008216 ◽  
Author(s):  
Constância F. J. Ayres ◽  
Gonçalo Seixas ◽  
Sílvia Borrego ◽  
Cátia Marques ◽  
Inilça Monteiro ◽  
...  
Keyword(s):  
Aedes Aegypti ◽  
Resistance Mutation ◽  
Central Africa ◽  
Knockdown Resistance ◽  
West And Central Africa

scholarly journals Estimations of Fine-Scale Species Distributions of Aedes aegypti and Aedes albopictus (Diptera: Culicidae) in Eastern Florida

2020 ◽  
Author(s):  
Kristen A Hopperstad ◽  
Mohamed F Sallam ◽  
Michael H Reiskind
Keyword(s):  
Aedes Aegypti ◽  
Aedes Albopictus ◽  
Habitat Suitability ◽  
Population Data ◽  
Fine Scale ◽  
Distribution Maps ◽  
Central Florida ◽  
Urban Land Cover ◽  
Suitability Maps ◽  
Minimum Daily Temperature

Abstract Many species distribution maps indicate the ranges of Aedes aegypti (Linnaeus) and Aedes albopictus (Skuse) overlap in Florida despite the well-documented range reduction of Ae. aegypti. Within the last 30 yr, competitive displacement of Ae. aegypti by Ae. albopictus has resulted in partial spatial segregation of the two species, with Ae. aegypti persisting primarily in urban refugia. We modeled fine-scale distributions of both species, with the goal of capturing the outcome of interspecific competition across space by building habitat suitability maps. We empirically parameterized models by sampling 59 sites in south and central Florida over time and incorporated climatic, landscape, and human population data to identify predictors of habitat suitability for both species. Our results show human density, precipitation, and urban land cover drive Ae. aegypti habitat suitability, compared with exclusively climatic variables driving Ae. albopictus habitat suitability. Remotely sensed variables (macrohabitat) were more predictive than locally collected metrics (microhabitat), although recorded minimum daily temperature showed significant, inverse relationships with both species. We detected minor Aedes habitat segregation; some periurban areas that were highly suitable for Ae. albopictus were unsuitable for Ae. aegypti. Fine-scale empirical models like those presented here have the potential for precise risk assessment and the improvement of operational applications to control container-breeding Aedes mosquitoes.

scholarly journals Cocirculation of two dengue virus serotypes in individual and pooled samples of Aedes aegypti and Aedes albopictus larvae

2011 ◽  
Vol 44 (1) ◽  
pp. 103-105 ◽  
Author(s):  
José Eduardo Marques Pessanha ◽  
Waleska Teixeira Caiaffa ◽  
Alzira Batista Cecilio ◽  
Felipe Campos de Melo Iani ◽  
Simone Costa Araujo ◽  
...  
Keyword(s):  
Aedes Aegypti ◽  
Dengue Virus ◽  
Clinical Presentation ◽  
Rt Pcr ◽  
Virus Rna ◽  
Dengue Virus Serotypes ◽  
Belo Horizonte ◽  
The City ◽  
Pooled Samples ◽  
Virological Surveillance

INTRODUCTION: To detect dengue virus, eggs of Aedes sp were collected in the city of Belo Horizonte, Brazil, in 2007. METHODS: Egg samples were subsequently hatched and the larvae were tested for the presence of dengue virus RNA by RT-PCR. RESULTS: Among the Aedes aegypti larvae samples, 163 (37.4%) out of 435 were positive, including 32 (10.9%) of 293 individual larvae samples concomitantly positive for two serotypes. CONCLUSIONS: Virological surveillance detecting coinfected vectors in the field could represent an important strategy for understanding the numerous factors involved in the transmission and clinical presentation of dengue.

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