scholarly journals Role of hypocretin in the medial preoptic area in the regulation of sleep, maternal behavior and body temperature of lactating rats.

2021 ◽  
Author(s):  
Mayda Rivas ◽  
Diego Serantes ◽  
Florencia Pena ◽  
Joaquin Gonzalez ◽  
Annabel Ferreira ◽  
...  
Keyword(s):  
Body Temperature ◽  
Lateral Hypothalamus ◽  
Maternal Behavior ◽  
Opposite Effect ◽  
Preoptic Area ◽  
Medial Preoptic Area ◽  
Milk Ejection ◽  
Wide Range ◽  
The Brain

The hypocretins (HCRT), also known as orexin, includes two neuroexcitatory peptides, HCRT-1 and HCRT-2 (orexin A y B, respectively), synthesized by neurons located in the postero-lateral hypothalamus, whose projections and receptors are widely distributed throughout the brain, including the medial preoptic area (mPOA). HCRT have been associated with a wide range of physiological functions including sleep-wake cycle, maternal behavior and body temperature, all regulated by the mPOA. Previously we showed that HCRT in the mPOA facilitates certain active maternal behaviors, while the blockade of HCRT-R1 increased the time spent in nursing. As mother rats mainly sleep while they nurse, we hypothesize that HCRT in the mPOA of lactating rats reduce sleep and nursing, while the intra-mPOA administration of the dual orexin receptor antagonist (DORA) would generate the opposite effect. Therefore, the aim of this study was to determine the role of HCRT within the mPOA, in the regulation and integration of the sleep-wake cycle, maternal behavior and body temperature of lactating rats. To evaluate this idea, we assessed the sleep-wake states, maternal behavior and body temperature of lactating rats following microinjections of HCRT-1 (100 and 200 uM) and DORA (5mM) into the mPOA. As expected, our data shows that HCRT-1 in mPOA promoted wakefulness and a slightly increase in body temperature, whereas DORA increased both NREM and REM sleep along with nursing and milk ejection. Taken together, our results strongly suggest that the reduction of the endogenous HCRT within the mPOA of lactating rats is important to promote sleep, nursing and milk ejection.

scholarly journals Role of hypocretin in the medial preoptic area in the regulation of sleep, maternal behavior and body temperature of lactating rats

Neuroscience ◽  
2021 ◽  
Author(s):  
Mayda Rivas ◽  
Diego Serantes ◽  
Florencia Peña ◽  
Joaquín González ◽  
Annabel Ferreira ◽  
...  
Keyword(s):  
Body Temperature ◽  
Maternal Behavior ◽  
Preoptic Area ◽  
Medial Preoptic Area

scholarly journals Prolactin action in the medial preoptic area is necessary for postpartum maternal nursing behavior

2017 ◽  
Vol 114 (40) ◽  
pp. 10779-10784 ◽  
Author(s):  
Rosemary S. E. Brown ◽  
Mari Aoki ◽  
Sharon R. Ladyman ◽  
Hollian R. Phillipps ◽  
Amanda Wyatt ◽  
...  
Keyword(s):  
Maternal Behavior ◽  
Maternal Care ◽  
Preoptic Area ◽  
Neural Circuit ◽  
Critical Role ◽  
Medial Preoptic Area ◽  
Prolactin Signaling ◽  
Maternal Brain ◽  
Normal Expression

Pregnancy hormones, such as prolactin, sensitize neural circuits controlling parental interactions to induce timely activation of maternal behaviors immediately after parturition. While the medial preoptic area (MPOA) is known to be critical for maternal behavior, the specific role of prolactin in this brain region has remained elusive. Here, we evaluated the role of prolactin action in the MPOA using complementary genetic strategies in mice. We characterized prolactin-responsive neurons within the MPOA at different hormonal stages and delineated their projections in the brain. We found that MPOA neurons expressing prolactin receptors (Prlr) form the nexus of a complex prolactin-responsive neural circuit, indicating that changing prolactin levels can act at multiple sites and thus, impinge on the overall activity of a distributed network of neurons. Conditional KO of Prlr from neuronal subpopulations expressing the neurotransmitters GABA or glutamate within this circuit markedly reduced the capacity for prolactin action both in the MPOA and throughout the network. Each of these manipulations, however, produced only subtle impacts on maternal care, suggesting that this distributed circuit is robust with respect to alterations in prolactin signaling. In contrast, acute deletion of Prlr in all MPOA neurons of adult female mice resulted in profound deficits in maternal care soon after birth. All mothers abandoned their pups, showing that prolactin action on MPOA neurons is necessary for the normal expression of postpartum maternal behavior in mice. Our data establish a critical role for prolactin-induced behavioral responses in the maternal brain, ensuring survival of mammalian offspring.

A functional neuroanatomical investigation of the role of the medial preoptic area in neural circuits regulating maternal behavior

2002 ◽  
Vol 131 (1-2) ◽  
pp. 17-36 ◽  
Author(s):  
Edward C Stack ◽  
Revathi Balakrishnan ◽  
Marilyn J Numan ◽  
Michael Numan
Keyword(s):  
Maternal Behavior ◽  
Neural Circuits ◽  
Preoptic Area ◽  
Medial Preoptic Area

scholarly journals A Scientometric Approach to Review the Role of the Medial Preoptic Area (MPOA) in Parental Behavior

2021 ◽  
Vol 11 (3) ◽  
pp. 393
Author(s):  
Alessandro Carollo ◽  
Jan Paolo Macapinlac Balagtas ◽  
Michelle Jin-Yee Neoh ◽  
Gianluca Esposito
Keyword(s):  
Preoptic Area ◽  
Parental Behavior ◽  
Neural Substrates ◽  
Medial Preoptic Area ◽  
Brain Network ◽  
Scientometric Analysis ◽  
Parental Behaviour ◽  
Scientific Papers ◽  
The Relationship

Research investigating the neural substrates underpinning parental behaviour has recently gained momentum. Particularly, the hypothalamic medial preoptic area (MPOA) has been identified as a crucial region for parenting. The current study conducted a scientometric analysis of publications from 1 January 1972 to 19 January 2021 using CiteSpace software to determine trends in the scientific literature exploring the relationship between MPOA and parental behaviour. In total, 677 scientific papers were analysed, producing a network of 1509 nodes and 5498 links. Four major clusters were identified: “C-Fos Expression”, “Lactating Rat”, “Medial Preoptic Area Interaction” and “Parental Behavior”. Their content suggests an initial trend in which the properties of the MPOA in response to parental behavior were studied, followed by a growing attention towards the presence of a brain network, including the reward circuits, regulating such behavior. Furthermore, while attention was initially directed uniquely to maternal behavior, it has recently been extended to the understanding of paternal behaviors as well. Finally, although the majority of the studies were conducted on rodents, recent publications broaden the implications of previous documents to human parental behavior, giving insight into the mechanisms underlying postpartum depression. Potential directions in future works were also discussed.

Effects of small medial preoptic area lesions on maternal behavior: Retreiving and nest building in the rat

1980 ◽  
Vol 194 (2) ◽  
pp. 471-478 ◽  
Author(s):  
Carol D. Jacobson ◽  
Joseph Terkel ◽  
Roger A. Gorski ◽  
Charles H. Sawyer
Keyword(s):  
Maternal Behavior ◽  
Preoptic Area ◽  
Medial Preoptic Area ◽  
Nest Building
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