scholarly journals The cost-effectiveness of accelerated partner therapy (APT) compared to standard contact tracing for people with chlamydia: an economic evaluation based on the LUSTRUM population-based chlamydia transmission model

2021 ◽  
Author(s):  
Eleanor V. Williams ◽  
Chidubem B. Okeke Ogwulu ◽  
Claudia S. Estcourt ◽  
Alison R. Howarth ◽  
Andrew Copas ◽  
...  
Keyword(s):  
United Kingdom ◽  
Cost Effectiveness ◽  
Population Based ◽  
Contact Tracing ◽  
Chlamydia Infection ◽  
The United Kingdom ◽  
Intervention Cost ◽  
Standard Contact ◽  
The Cost ◽  
The Impact

Objective: To investigate the cost-effectiveness of accelerated partner therapy (APT) compared with standard contact tracing for people with sexually transmitted chlamydia infection in the United Kingdom Design: Economic evaluation using a model consisting of two components: a population-based chlamydia transmission component, to estimate the impact of APT on chlamydia prevalence, and an economic component, to estimate the impact of APT on healthcare costs and health outcomes. Setting: United Kingdom Participants: Hypothetical heterosexual population of 50,000 men and 50,000 women aged 16-34 years. Main Outcome Measures: Cost-effectiveness based on quality-adjusted life years (QALYs) gained and major outcomes averted (MOA), defined as mild pelvic inflammatory disease (PID), severe PID, chronic pelvic pain, ectopic pregnancy, tubal factor infertility and epididymitis. Results: For a model population of 50,000 men and 50,000 women and an APT intervention lasting 5 years, the intervention cost of APT (&pound135,201) is greater than the intervention cost of standard contact tracing (&pound116,334). When the costs of complications arising from chlamydia are considered, the total cost of APT (&pound370,657) is lower than standard contact tracing (&pound379,597). Thus, APT yields a total cost saving of approximately &pound9000 and leads to 73 fewer major outcomes and 21 fewer QALYs lost. Hence, APT is the dominant PN strategy. APT remained cost-effective across the full range of sensitivity analyses. Conclusions: Based on cost-effectiveness grounds APT is likely to be recommended as an alternative to standard contact tracing for chlamydia infection in the United Kingdom

scholarly journals Variations in cost calculations in spine surgery cost-effectiveness research

2014 ◽  
Vol 36 (6) ◽  
pp. E1 ◽  
Author(s):  
Matthew D. Alvin ◽  
Jacob A. Miller ◽  
Daniel Lubelski ◽  
Benjamin P. Rosenbaum ◽  
Kalil G. Abdullah ◽  
...  
Keyword(s):  
United Kingdom ◽  
Cost Effectiveness ◽  
Spine Surgery ◽  
Indirect Costs ◽  
Cost Calculation ◽  
Effectiveness Research ◽  
Reimbursement System ◽  
The United Kingdom ◽  
The Cost ◽  
Effectiveness Studies

Object Cost-effectiveness research in spine surgery has been a prominent focus over the last decade. However, there has yet to be a standardized method developed for calculation of costs in such studies. This lack of a standardized costing methodology may lead to conflicting conclusions on the cost-effectiveness of an intervention for a specific diagnosis. The primary objective of this study was to systematically review all cost-effectiveness studies published on spine surgery and compare and contrast various costing methodologies used. Methods The authors performed a systematic review of the cost-effectiveness literature related to spine surgery. All cost-effectiveness analyses pertaining to spine surgery were identified using the cost-effectiveness analysis registry database of the Tufts Medical Center Institute for Clinical Research and Health Policy, and the MEDLINE database. Each article was reviewed to determine the study subject, methodology, and results. Data were collected from each study, including costs, interventions, cost calculation method, perspective of cost calculation, and definitions of direct and indirect costs if available. Results Thirty-seven cost-effectiveness studies on spine surgery were included in the present study. Twenty-seven (73%) of the studies involved the lumbar spine and the remaining 10 (27%) involved the cervical spine. Of the 37 studies, 13 (35%) used Medicare reimbursements, 12 (32%) used a case-costing database, 3 (8%) used cost-to-charge ratios (CCRs), 2 (5%) used a combination of Medicare reimbursements and CCRs, 3 (8%) used the United Kingdom National Health Service reimbursement system, 2 (5%) used a Dutch reimbursement system, 1 (3%) used the United Kingdom Department of Health data, and 1 (3%) used the Tricare Military Reimbursement system. Nineteen (51%) studies completed their cost analysis from the societal perspective, 11 (30%) from the hospital perspective, and 7 (19%) from the payer perspective. Of those studies with a societal perspective, 14 (38%) reported actual indirect costs. Conclusions Changes in cost have a direct impact on the value equation for concluding whether an intervention is cost-effective. It is essential to develop a standardized, accurate means of calculating costs. Comparability and transparency are essential, such that studies can be compared properly and policy makers can be appropriately informed when making decisions for our health care system based on the results of these studies.

scholarly journals Risk and Prevention of Meningococcal Disease among Education Workers: A Review

2004 ◽  
Vol 15 (2) ◽  
pp. 89-93 ◽  
Author(s):  
Philippe De Wals ◽  
Pierre Deshaies ◽  
Gaston De Serres ◽  
Bernard Duval ◽  
Lise Goulet ◽  
...  
Keyword(s):  
United Kingdom ◽  
Pregnant Women ◽  
Meningococcal Disease ◽  
Disease Risk ◽  
The United States ◽  
Population Based ◽  
Work Place ◽  
Societal Benefit ◽  
The United Kingdom ◽  
The Cost

The aims of the present study were to review the risk of invasive meningococcal disease (IMD) among education workers, particularly pregnant women, and to evaluate preventive measures, in a context of endemicity, outbreak or epidemic as observed in the province of Quebec. The literature was reviewed and persons in charge of IMD surveillance in France, Quebec, the United Kingdom and the United States were interviewed. Surveys of asymptomatic carriage ofNeisseria meningitidisshow that transmission among students is higher than transmission between students and teachers. IMD incidence among education workers was analyzed in Cheshire (United Kingdom) in the period from 1997 to 1999, and the results indicated a risk six times higher than that in the general population. Overestimation of the magnitude of the risk is possible because the analysis focused on a cluster. None of the population-based studies of IMD mentioned a risk of secondary cases among education workers. Six IMD cases in education workers were identified in five clusters in schools in the United Kingdom, but not in the other countries. There is no epidemiological study on IMD risk among pregnant women, and this factor was not mentioned in any published review of IMD. Immunization of education workers at the beginning of their employment, using serogroup C glycoconjugate vaccine or a combined A, C, W-135, and Y conjugate vaccine (still under development), could reduce IMD risk, but the cost effectiveness of this measure should be evaluated. The societal benefit of excluding pregnant women from the work place during an outbreak seems to be very low, even if disease risk could be decreased for this specific group. When chemoprophylaxis is indicated for the control of an outbreak in an educational setting, treatment should be offered both to students and teachers in the group at risk.

scholarly journals Evaluation of the cost-effectiveness of rifaximin-α for the management of patients with hepatic encephalopathy in the United Kingdom

2018 ◽  
Vol 34 (11) ◽  
pp. 2001-2008 ◽  
Author(s):  
Ellen Berni ◽  
Daniel Murphy ◽  
James Whitehouse ◽  
Pete Conway ◽  
Paola Di Maggio ◽  
...  
Keyword(s):  
United Kingdom ◽  
Cost Effectiveness ◽  
Hepatic Encephalopathy ◽  
The United Kingdom ◽  
The Cost

Expanded Function Orthodontic Auxiliaries; a Proposal for their Introduction in the UK

1988 ◽  
Vol 15 (4) ◽  
pp. 281-286 ◽  
Author(s):  
K. D. O'Brien ◽  
W. C. Shaw
Keyword(s):  
United States ◽  
United Kingdom ◽  
Cost Effectiveness ◽  
Orthodontic Treatment ◽  
The United States ◽  
The United Kingdom ◽  
Treatment Provision ◽  
The Uk ◽  
The Cost

The role of dental and orthodontic auxiliaries in Europe and the United States is reviewed, and the advantages of their employment in the United Kingdom are discussed in terms of increasing the cost-effectiveness of orthodontic treatment provision. A three-stage programme for the evaluation of Orthodontic Auxiliaries in the UK is proposed.

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