scholarly journals Mechanisms underlying generation of gradients in gene expression within the intestine: an analysis using transgenic mice containing fatty acid binding protein-human growth hormone fusion genes.

1988 ◽  
Vol 2 (10) ◽  
pp. 1318-1332 ◽  
Author(s):  
D A Sweetser ◽  
E H Birkenmeier ◽  
P C Hoppe ◽  
D W McKeel ◽  
J I Gordon
Keyword(s):  
Gene Expression ◽  
Growth Hormone ◽  
Fatty Acid ◽  
Transgenic Mice ◽  
Human Growth Hormone ◽  
Fatty Acid Binding Protein ◽  
Human Growth ◽  
Fusion Genes ◽  
Fatty Acid Binding ◽  
Acid Binding Protein

Gonadotropin secretion, synthesis, and gene expression in human growth hormone transgenic mice and in Ames dwarf mice.

Endocrinology ◽  
1993 ◽  
Vol 132 (6) ◽  
pp. 2518-2524 ◽  
Author(s):  
K Tang ◽  
A Bartke ◽  
C S Gardiner ◽  
T E Wagner ◽  
J S Yun
Keyword(s):  
Gene Expression ◽  
Growth Hormone ◽  
Transgenic Mice ◽  
Human Growth Hormone ◽  
Human Growth ◽  
Gonadotropin Secretion ◽  
Ames Dwarf Mice ◽  
Ames Dwarf ◽  
Dwarf Mice

Gene Expression of Heart- and Adipocyte-Fatty Acid-Binding Protein and Correlation With Intramuscular Fat in Chinese Chickens

2008 ◽  
Vol 19 (3) ◽  
pp. 190-194 ◽  
Author(s):  
W. J. Li ◽  
H. B. Li ◽  
J. L. Chen ◽  
G. P. Zhao ◽  
M. Q. Zheng ◽  
...  
Keyword(s):  
Gene Expression ◽  
Fatty Acid ◽  
Fatty Acid Binding Protein ◽  
Binding Protein ◽  
Intramuscular Fat ◽  
Fatty Acid Binding ◽  
Acid Binding Protein

scholarly journals Urinary fatty acid-binding protein 1: an early predictive biomarker of kidney injury

2009 ◽  
Vol 296 (4) ◽  
pp. F669-F679 ◽  
Author(s):  
Eisei Noiri ◽  
Kent Doi ◽  
Kousuke Negishi ◽  
Tamami Tanaka ◽  
Yoshifumi Hamasaki ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Kidney Disease ◽  
Transgenic Mice ◽  
Fatty Acid Binding Protein ◽  
Binding Protein ◽  
Kidney Injury ◽  
Predictive Biomarker ◽  
Clinical Samples ◽  
Fatty Acid Binding ◽  
Acid Binding Protein

In the development of novel therapeutic strategies for kidney disease, new renal biomarkers for early detection and accurate evaluation of renal injury are urgently required for both acute kidney injury (AKI) and chronic kidney disease (CKD). Fatty acid-binding protein 1 (FABP1) is expressed in renal proximal tubule cells and shed into urine in response to hypoxia caused by decreased peritubular capillary blood flow. To clarify the role of urinary FABP1 in kidney disease, we established human FABP1 transgenic mice and evaluated the responses of FABP1 to several AKI and CKD models. Moreover, there are accumulating clinical data that urinary FABP1 can detect human AKI earlier than serum creatinine and can distinguish the risk population for AKI. Investigation with “humanized” FABP1 transgenic mice and measurement of clinical samples allowed us to develop urinary FABP1 as a new renal biomarker. Further clinical studies are necessary to confirm the potential of urinary FABP1 for clinical application.

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