scholarly journals Bipolar mood tendency and frontal activation using a multichannel near infrared spectroscopy

2015 ◽  
Vol 7 (2) ◽  
pp. 36-41
Author(s):  
Toru Uehara ◽  
Yoko Ishige
Keyword(s):  
Infrared Spectroscopy ◽  
Near Infrared Spectroscopy ◽  
Near Infrared ◽  
Cerebral Blood Volume ◽  
Bipolar Disorders ◽  
Self Report ◽  
Two Samples ◽  
The Right ◽  
Privacy And Anonymity ◽  
Frontal Functioning

This study aims to examine the association of frontal functioning with subclinical bipolar spectrum by a newly developed convenient method. We investigated subclinical bipolar tendency and frontal lobe activation during word productions using multi-channel near infrared spectroscopy. Participants: 44 healthy university students (mean ages 20.5 years old, and 29 female) gave their written informed consent, and we strictly protected privacy and anonymity was carefully preserved. A 13-items self-report questionnaire (Mood Disorders Questionnaire; MDQ) and a 16-channel near-infrared spectroscopy were used to compare frontal activations between two samples divided by median (4 points) of the total MDQ scores and to analyze correlations between relative changes of cerebral blood volume and bipolarity levels. There was no case suspected as bipolar disorders by MDQ screening (mean 3.4, max 10). Significant differences in lower activations were noted in the right and left pre-frontal cortex (PFC) with higher bipolarity scores using the specific software to analyze the NIRS waveform (P<0.05). Total MDQ were correlated significantly with frontal activation negatively in many channels; therefore, we conducted multiple linear regression to select significant frontal activations using the MDQ as a dependent variable. Stepwise method revealed that activation in left lateral PFC was negatively associated to bipolar tendency, and this regression model was significant (R2=0.10, F=4.5, P=0.04). Differences in frontal functioning suggest that subclinical bipolar tendencies might be related to left lateral PFC activations. It should be confirmed whether the identical pattern can be identified for clinical subjects with bipolar disorders.

scholarly journals Bipolar mood tendency and frontal activation using a multichannel near infrared spectroscopy

2015 ◽  
Vol 7 (2) ◽  
Author(s):  
Toru Uehara ◽  
Yoko Ishige
Keyword(s):  
Infrared Spectroscopy ◽  
Near Infrared Spectroscopy ◽  
Near Infrared ◽  
Cerebral Blood Volume ◽  
Bipolar Disorders ◽  
Self Report ◽  
Two Samples ◽  
The Right ◽  
Privacy And Anonymity ◽  
Frontal Functioning

This study aims to examine the association of frontal functioning with subclinical bipolar spectrum by a newly developed convenient method. We investigated subclinical bipolar tendency and frontal lobe activation during word productions using multi-channel near infrared spectroscopy. Participants: 44 healthy university students (mean ages 20.5 years old, and 29 female) gave their written informed consent, and we strictly protected privacy and anonymity was carefully preserved. A 13-items self-report questionnaire (Mood Disorders Questionnaire; MDQ) and a 16-channel near-infrared spectroscopy were used to compare frontal activations between two samples divided by median (4 points) of the total MDQ scores and to analyze correlations between relative changes of cerebral blood volume and bipolarity levels. There was no case suspected as bipolar disorders by MDQ screening (mean 3.4, max 10). Significant differences in lower activations were noted in the right and left pre-frontal cortex (PFC) with higher bipolarity scores using the specific software to analyze the NIRS waveform (P&lt;0.05). Total MDQ were correlated significantly with frontal activation negatively in many channels; therefore, we conducted multiple linear regression to select significant frontal activations using the MDQ as a dependent variable. Stepwise method revealed that activation in left lateral PFC was negatively associated to bipolar tendency, and this regression model was significant (R2=0.10, F=4.5, P=0.04). Differences in frontal functioning suggest that subclinical bipolar tendencies might be related to left lateral PFC activations. It should be confirmed whether the identical pattern can be identified for clinical subjects with bipolar disorders.

scholarly journals Can Cerebral Blood Volume Be Measured Reproducibly with an Improved near Infrared Spectroscopy System?

2001 ◽  
Vol 21 (2) ◽  
pp. 110-113 ◽  
Author(s):  
Marjo J. T. Van de Ven ◽  
Willy N. J. M. Colier ◽  
Marco C. van der Sluijs ◽  
Diederik Walraven ◽  
Berend Oeseburg ◽  
...  
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Infrared Spectroscopy ◽  
Blood Volume ◽  
Near Infrared Spectroscopy ◽  
Healthy Subjects ◽  
Baseline Level ◽  
Near Infrared ◽  
Cerebral Blood Volume ◽  
Spectroscopy System

In some circumstances, cerebral blood volume (CBV) can be used as a measure for cerebral blood flow. A new near infrared spectroscope was used for determining the reproducibility of CBV measurements assessed by the O2-method. Twenty-seven healthy subjects were investigated. An intrasubject coefficient of variation (CV) was calculated, based on four identical episodes of desaturation–resaturation (O2-method) procedures for CBV measurements. Two trials were performed, with (trial 1) and without (trial 2) disconnecting the equipment. A mean CV of 12.6% and 10.0% was found in trial 1 and 2, respectively. Cerebral blood volume values yield 3.60 ± 0.82 mL 100 g−1. Cerebral blood volume could be measured reproducible in adults using near infrared spectroscopy, if the arterial desaturation is limited to approximately 5% from baseline level.

The neural correlates of inhibitory control in 10-month-old infants: a functional near-infrared spectroscopy study

2021 ◽  
Author(s):  
Abigail Fiske ◽  
Carina de Klerk ◽  
Katie Y. K. Lui ◽  
Liam H Collins-Jones ◽  
Alexandra Hendry ◽  
...  
Keyword(s):  
Infrared Spectroscopy ◽  
Inhibitory Control ◽  
Near Infrared Spectroscopy ◽  
Response Inhibition ◽  
Near Infrared ◽  
Neural Correlates ◽  
Older Children ◽  
Functional Near Infrared Spectroscopy ◽  
Inhibition Performance ◽  
The Right

Inhibitory control, a core executive function, emerges in infancy and develops rapidly across childhood. Methodological limitations have meant that studies investigating the neural correlates underlying inhibitory control in infancy are rare. Employing functional near-infrared spectroscopy alongside a novel touchscreen task that measures response inhibition, this study aimed to uncover the neural underpinnings of inhibitory control in 10-month-old infants (N = 135). We found that when inhibition is required, the right prefrontal and parietal cortices were more activated than when there is no inhibitory demand. Further, activation in right prefrontal areas was associated with individual differences in response inhibition performance. This demonstrates that inhibitory control in infants as young as 10 months of age is supported by similar brain areas as in older children and adults. With this study we have lowered the age-boundary for localising the neural substrates of response inhibition to the first year of life.

scholarly journals Near-Infrared Spectroscopy Reveals Abnormal Hemodynamics in the Left Dorsolateral Prefrontal Cortex of Menopausal Depression Patients

2017 ◽  
Vol 2017 ◽  
pp. 1-10 ◽  
Author(s):  
Xiang-Yun Ma ◽  
Yong-Jun Wang ◽  
Bo Xu ◽  
Kun Feng ◽  
Gao-Xiang Sun ◽  
...  
Keyword(s):  
Prefrontal Cortex ◽  
Infrared Spectroscopy ◽  
Near Infrared Spectroscopy ◽  
Near Infrared ◽  
Verbal Fluency Task ◽  
Left Dlpfc ◽  
Significant Difference ◽  
The Difference ◽  
The Right ◽  
Menopausal Depression

Background/Objective. Menopausal depression (MD) is characterized by depressive symptoms along with hormonal fluctuations. We investigate brain function alteration between major depressive disorder (MDD) and MD.Methods. The difference in oxygenated hemoglobin (Oxy-Hb) for the prefrontal cortex (PFC) was compared retrospectively among 90 females presented with 30 MDD, 30 MD, and 30 healthy controls (HCs) using verbal fluency task (VFT) with near-infrared spectroscopy (NIRS).Results. We observed a significant difference in Oxy-Hb alteration in the left dorsolateral PFC (DLPFC) using VFT with NIRS (channel 18,P=0.007) between the MD and MDD groups. A significant difference in Oxy-Hb levels was observed among the three groups in the bilateral DLPFC (channels 18, 27, 33, 39, 41, and 45;P<0.05). Compared to the HCs, the MD group presented lower Oxy-Hb activation in the right DLPFC (channel 41;P=0.048) and the left DLPFC (channels 18, 39, and 45;P<0.05), and the MDD group presented lower Oxy-Hb activation in the right DLPFC (channels 27, 33, and 41;P<0.05) and the left DLPFC (channels 39 and 45;P<0.05).Conclusion. Abnormal hemodynamics of the left DLPFC can differentiate MD from MDD by NIRS.

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